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Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 [ Mus musculus (house mouse) ]

Gene ID: 18213, updated on 8-May-2016
Official Symbol
Ntrk3provided by MGI
Official Full Name
neurotrophic tyrosine kinase, receptor, type 3provided by MGI
Primary source
MGI:MGI:97385
See related
Ensembl:ENSMUSG00000059146 Vega:OTTMUSG00000021139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TrkC; AW125844; Ntrk3_tv3
Orthologs
Location:
7 D3; 7 44.01 cM
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (78179986..78578852, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (85337000..85722724, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 1 Neighboring gene predicted gene, 33069 Neighboring gene proliferating cell nuclear antigen pseudogene Neighboring gene RIKEN cDNA E430016F16 gene Neighboring gene predicted gene, 39038 Neighboring gene predicted gene, 30892

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GPI-linked ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
neurotrophin receptor activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
lens fiber cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
mechanoreceptor differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron fate specification ISO
Inferred from Sequence Orthology
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of axon extension involved in regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
NT-3 growth factor receptor
Names
GP145-TrkC
neurotrophin-3
trk-C
trkC tyrosine kinase
NP_032772.3
NP_877961.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008746.5NP_032772.3  NT-3 growth factor receptor isoform a precursor

    See identical proteins and their annotated locations for NP_032772.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC108420, AC115868, AC121082, AK164887
    Consensus CDS
    CCDS21371.1
    UniProtKB/Swiss-Prot
    Q6VNS1
    UniProtKB/TrEMBL
    Q3TNY3
    Related
    ENSMUSP00000037909, OTTMUSP00000023300, ENSMUST00000039431, OTTMUST00000050042
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00082
    Location:160208
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    pfam07714
    Location:538810
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    cd05094
    Location:532818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
  2. NM_182809.2NP_877961.1  NT-3 growth factor receptor isoform b precursor

    See identical proteins and their annotated locations for NP_877961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the CDS and the 3' UTR, compared to variant 1. This results in a shorter isoform (b) with a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC121082, AF035400, BE950984
    Consensus CDS
    CCDS21372.1
    UniProtKB/Swiss-Prot
    Q6VNS1
    Related
    ENSMUSP00000038324, OTTMUSP00000023301, ENSMUST00000039438, OTTMUST00000050043
    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:3156
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:160205
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    78179986..78578852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250816.1XP_011249118.1  

    See identical proteins and their annotated locations for XP_011249118.1

    UniProtKB/TrEMBL
    A0A0A6YWL7
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00082
    Location:160205
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    pfam07714
    Location:538849
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    cd05094
    Location:532857
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
  2. XM_011250817.1XP_011249119.1  

    See identical proteins and their annotated locations for XP_011249119.1

    UniProtKB/TrEMBL
    A0A0A6YWF9
    Related
    ENSMUSP00000141534, OTTMUSP00000070142, ENSMUST00000193002, OTTMUST00000131059
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00082
    Location:160205
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    pfam07714
    Location:538824
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    cd05094
    Location:532832
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
  3. XM_006540691.2XP_006540754.1  

    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00082
    Location:160205
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    pfam07714
    Location:538835
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    cd05094
    Location:532843
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
  4. XM_011250815.1XP_011249117.1  

    See identical proteins and their annotated locations for XP_011249117.1

    UniProtKB/TrEMBL
    A0A0A6YWL7
    Related
    ENSMUSP00000141599, OTTMUSP00000070141, ENSMUST00000195262, OTTMUST00000131058
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00082
    Location:160205
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    pfam07714
    Location:538849
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    cd05094
    Location:532857
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
  5. XM_006540692.2XP_006540755.1  

    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:3156
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:160205
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]

RNA

  1. XR_882023.1 RNA Sequence

  2. XR_882022.1 RNA Sequence

  3. XR_882025.1 RNA Sequence

  4. XR_882024.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    75610791..75991488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. NW_001074373.1 Alternate Mm_Celera

    Range
    1150..1782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)