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Nsmaf neutral sphingomyelinase (N-SMase) activation associated factor [ Mus musculus (house mouse) ]

Gene ID: 18201, updated on 28-May-2016
Official Symbol
Nsmafprovided by MGI
Official Full Name
neutral sphingomyelinase (N-SMase) activation associated factorprovided by MGI
Primary source
MGI:MGI:1341864
See related
Ensembl:ENSMUSG00000028245 Vega:OTTMUSG00000004313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fan; AA959567; C630007J05
Orthologs
Location:
4; 4 A1
Exon count:
35
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (6396207..6454668, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (6323354..6381418, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930430E12 gene Neighboring gene syndecan binding protein Neighboring gene Friend virus susceptibility protein 1-like Neighboring gene predicted gene 11802 Neighboring gene thymocyte selection-associated high mobility group box

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
death receptor binding TAS
Traceable Author Statement
more info
PubMed 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
sphingomyelin phosphodiesterase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
protein FAN
Names
factor associated with N-SMase activation
factor associated with neutral sphingomyelinase activation

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010945.2NP_035075.2  protein FAN

    See identical proteins and their annotated locations for NP_035075.2

    Status: VALIDATED

    Source sequence(s)
    BC145963, BY729997, CO043098
    Consensus CDS
    CCDS17952.1
    UniProtKB/Swiss-Prot
    O35242
    Related
    ENSMUSP00000029910, OTTMUSP00000004698, ENSMUST00000029910, OTTMUST00000009770
    Conserved Domains (4) summary
    cd06071
    Location:302575
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:558919
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:625917
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:192285
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    6396207..6454668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537664.2XP_006537727.1  

    Conserved Domains (4) summary
    cd06071
    Location:302575
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:558926
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:625924
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:192285
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
  2. XM_006537663.2XP_006537726.1  

    Conserved Domains (4) summary
    cd06071
    Location:331604
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:587948
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:654946
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:221314
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
  3. XM_006537662.2XP_006537725.1  

    Conserved Domains (4) summary
    cd06071
    Location:331604
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:587955
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:654953
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:221314
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
  4. XM_006537665.1XP_006537728.1  

    Conserved Domains (4) summary
    cd06071
    Location:172445
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:428796
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:495794
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:62155
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
  5. XM_011249944.1XP_011248246.1  

    Conserved Domains (4) summary
    cd06071
    Location:331604
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:605772
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:646772
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:221314
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
  6. XM_011249943.1XP_011248245.1  

    Conserved Domains (4) summary
    cd06071
    Location:331604
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:605772
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:646772
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:221314
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

RNA

  1. XR_390314.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    6314494..6371636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)