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Nrxn1 neurexin I [ Mus musculus (house mouse) ]

Gene ID: 18189, updated on 17-May-2016
Official Symbol
Nrxn1provided by MGI
Official Full Name
neurexin Iprovided by MGI
Primary source
MGI:MGI:1096391
See related
Ensembl:ENSMUSG00000024109 Vega:OTTMUSG00000034567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0578; 1700062G21Rik; 9330127H16Rik; A230068P09Rik
Orthologs
Location:
17; 17 E5
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (90033644..91093100, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (90432984..91492142, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene predicted gene, 41653 Neighboring gene predicted gene, 32337 Neighboring gene prothymosin alpha pseudogene Neighboring gene RIKEN cDNA 4930480K15 gene Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene uncharacterized LOC102634481 Neighboring gene cullin 4A pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium channel regulator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
neuroligin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
neuroligin family protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
adult behavior ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
gephyrin clustering involved in postsynaptic density assembly IDA
Inferred from Direct Assay
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning ISO
Inferred from Sequence Orthology
more info
 
neuroligin clustering involved in postsynaptic membrane assembly IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
neurotransmitter secretion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic density protein 95 clustering IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane assembly IDA
Inferred from Direct Assay
more info
PubMed 
prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
regulation of grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
social behavior ISO
Inferred from Sequence Orthology
more info
 
synapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
 
vocal learning ISO
Inferred from Sequence Orthology
more info
 
vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
neurexin-1
Names
alpha-latrotoxin receptor (calcium-dependent)
neurexin 1 NRXN1+7a
neurexin 1 NRXN1-7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020252.3NP_064648.3  neurexin-1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB093249, AC167814, BC079893, CT486002
    Consensus CDS
    CCDS57113.1
    UniProtKB/Swiss-Prot
    Q9CS84
    Related
    ENSMUSP00000125407, OTTMUSP00000053430, ENSMUST00000160844, OTTMUST00000095739
    Conserved Domains (4) summary
    smart00294
    Location:14521470
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:680713
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:481650
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14321487
    Syndecan; Syndecan domain
  2. NM_177284.2NP_796258.2  neurexin-1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB093249, BC079893, CT486002
    Consensus CDS
    CCDS57112.1
    UniProtKB/Swiss-Prot
    Q9CS84
    UniProtKB/TrEMBL
    E0CY11
    Related
    ENSMUSP00000124561, OTTMUSP00000053429, ENSMUST00000160800, OTTMUST00000095738
    Conserved Domains (4) summary
    smart00294
    Location:14401458
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:668701
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:469638
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14201475
    Syndecan; Syndecan domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    90033644..91093100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523810.2XP_006523873.1  

    Conserved Domains (4) summary
    smart00294
    Location:14481466
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:667700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:468637
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14281483
    Syndecan; Syndecan domain
  2. XM_006523807.2XP_006523870.1  

    Conserved Domains (4) summary
    smart00294
    Location:14581476
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:677710
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:478647
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14381493
    Syndecan; Syndecan domain
  3. XM_006523804.2XP_006523867.1  

    Conserved Domains (4) summary
    smart00294
    Location:14621480
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:681714
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:482651
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14421497
    Syndecan; Syndecan domain
  4. XM_006523803.2XP_006523866.1  

    Conserved Domains (4) summary
    smart00294
    Location:14631481
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:682715
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:483652
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14431498
    Syndecan; Syndecan domain
  5. XM_011246317.1XP_011244619.1  

    Conserved Domains (4) summary
    smart00294
    Location:14671485
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:686719
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:487656
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14471502
    Syndecan; Syndecan domain
  6. XM_006523812.2XP_006523875.1  

    UniProtKB/Swiss-Prot
    Q9CS84
    Related
    ENSMUSP00000072458, OTTMUSP00000055380, ENSMUST00000072671, OTTMUST00000098514
    Conserved Domains (4) summary
    smart00294
    Location:14411459
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:672705
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:473642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14211476
    Syndecan; Syndecan domain
  7. XM_011246318.1XP_011244620.1  

    Conserved Domains (4) summary
    smart00294
    Location:14611479
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:680713
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:481650
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14411496
    Syndecan; Syndecan domain
  8. XM_006523815.2XP_006523878.1  

    Conserved Domains (4) summary
    smart00294
    Location:14241442
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:652685
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:453622
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14041459
    Syndecan; Syndecan domain
  9. XM_006523811.2XP_006523874.1  

    UniProtKB/Swiss-Prot
    Q9CS84
    Related
    ENSMUSP00000057294, OTTMUSP00000055788, ENSMUST00000054059, OTTMUST00000099376
    Conserved Domains (4) summary
    smart00294
    Location:14441462
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:672705
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:473642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14241479
    Syndecan; Syndecan domain
  10. XM_006523816.2XP_006523879.1  

    UniProtKB/Swiss-Prot
    Q9CS84
    Related
    ENSMUSP00000133491, OTTMUSP00000055377, ENSMUST00000174331, OTTMUST00000098509
    Conserved Domains (4) summary
    smart00294
    Location:14221440
    4.1m; putative band 4.1 homologues' binding motif
    cd00054
    Location:680713
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:481650
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14021457
    Syndecan; Syndecan domain
  11. XM_006523818.2XP_006523881.1  

    UniProtKB/TrEMBL
    E0CZA5
    Related
    ENSMUSP00000125561, OTTMUSP00000055376, ENSMUST00000159778, OTTMUST00000098508
    Conserved Domains (3) summary
    smart00294
    Location:383401
    4.1m; putative band 4.1 homologues' binding motif
    cd00110
    Location:86234
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:363418
    Syndecan; Syndecan domain

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    94417402..95489954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)