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Nrp2 neuropilin 2 [ Mus musculus (house mouse) ]

Gene ID: 18187, updated on 28-May-2016
Official Symbol
Nrp2provided by MGI
Official Full Name
neuropilin 2provided by MGI
Primary source
MGI:MGI:1100492
See related
Ensembl:ENSMUSG00000025969 Vega:OTTMUSG00000002566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Np2; Np-2; Npn2; Npn-2; 1110048P06Rik
Orthologs
Location:
1; 1 C2
Exon count:
18
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (62703317..62818692)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (62749891..62865266)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene par-3 family cell polarity regulator beta Neighboring gene predicted gene, 34881 Neighboring gene predicted gene, 39651 Neighboring gene RIKEN cDNA 4930487H11 gene Neighboring gene predicted gene 29083 Neighboring gene predicted gene, 35120 Neighboring gene predicted gene, 39652 Neighboring gene predicted gene 4208

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
heparin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
semaphorin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
dorsal root ganglion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
facial nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
facioacoustic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration involved in autonomic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
semaphorin-plexin signaling pathway involved in neuron projection guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
sympathetic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
sympathetic neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
sympathetic neuron projection guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
trigeminal ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
ventral trunk neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
vestibulocochlear nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IC
Inferred by Curator
more info
PubMed 
Preferred Names
neuropilin-2
Names
vascular endothelial cell growth factor 165 receptor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077403.1NP_001070871.1  neuropilin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001070871.1

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, AL671560, BY320114
    Consensus CDS
    CCDS35589.1
    UniProtKB/Swiss-Prot
    O35375
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000109794, OTTMUSP00000002409, ENSMUST00000114157, OTTMUST00000004998
    Conserved Domains (5) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:849928
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. NM_001077404.1NP_001070872.1  neuropilin-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070872.1

    Status: VALIDATED

    Source sequence(s)
    AK149643, AL671560, BC098200, BY320114
    Consensus CDS
    CCDS35590.1
    UniProtKB/TrEMBL
    Q8QZY7
    Related
    ENSMUSP00000069379, OTTMUSP00000002408, ENSMUST00000063594, OTTMUST00000004997
    Conserved Domains (5) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:844923
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. NM_001077405.1NP_001070873.1  neuropilin-2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, AL671560, BY320114
    Consensus CDS
    CCDS35591.1
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000099886, OTTMUSP00000002407, ENSMUST00000102822, OTTMUST00000004995
    Conserved Domains (5) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:827906
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. NM_001077406.1NP_001070874.1  neuropilin-2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001070874.1

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, AL671560, BY320114
    Consensus CDS
    CCDS35592.1
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000027112, OTTMUSP00000002411, ENSMUST00000027112, OTTMUST00000005002
    Conserved Domains (5) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:822901
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  5. NM_001077407.1NP_001070875.1  neuropilin-2 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001070875.1

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, BY320114
    Consensus CDS
    CCDS35593.1
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000109792, OTTMUSP00000002410, ENSMUST00000114155, OTTMUST00000004999
    Conserved Domains (5) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:817896
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  6. NM_010939.2NP_035069.2  neuropilin-2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_035069.2

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, AL671560, BY320114
    Consensus CDS
    CCDS14995.1
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000074642, OTTMUSP00000002412, ENSMUST00000075144, OTTMUST00000005003
    Conserved Domains (5) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:832911
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    62703317..62818692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    63214234..63328949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)