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Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 [ Mus musculus (house mouse) ]

Gene ID: 18173, updated on 8-May-2016
Official Symbol
Slc11a1provided by MGI
Official Full Name
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1provided by MGI
Primary source
MGI:MGI:1345275
See related
Ensembl:ENSMUSG00000026177 Vega:OTTMUSG00000016632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcg; Ity; Lsh; ity; Ity1; Nramp; Nramp1
Orthologs
Location:
1 C3; 1 38.54 cM
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (74375014..74386057)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74421777..74432625)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene paroxysmal nonkinesiogenic dyskinesia Neighboring gene ciliogenesis associated TTC17 interacting protein Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene ubiquitin specific peptidase 37

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC129156, MGC129157

Gene Ontology Provided by MGI

Function Evidence Code Pubs
manganese ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transition metal ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
L-arginine import IDA
Inferred from Direct Assay
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
MHC class II biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell proliferation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
antigen processing and presentation of peptide antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
cadmium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
cellular cadmium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
divalent metal ion export IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-3 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron ion transport ISO
Inferred from Sequence Orthology
more info
 
mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
manganese ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitrite transport IDA
Inferred from Direct Assay
more info
PubMed 
phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic cell antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory burst IDA
Inferred from Direct Assay
more info
PubMed 
response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to bacterium ISO
Inferred from Sequence Orthology
more info
 
response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
tertiary granule membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
natural resistance-associated macrophage protein 1
Names
NRAMP 1
host resistance locus Bcg/Ity/Lsh
solute carrier family 11 member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013612.2NP_038640.2  natural resistance-associated macrophage protein 1

    See identical proteins and their annotated locations for NP_038640.2

    Status: VALIDATED

    Source sequence(s)
    AK171393, BB873183
    Consensus CDS
    CCDS15047.1
    UniProtKB/Swiss-Prot
    P41251
    Related
    ENSMUSP00000027368, OTTMUSP00000017968, ENSMUST00000027368, OTTMUST00000040229
    Conserved Domains (2) summary
    TIGR01197
    Location:53453
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    pfam01566
    Location:75460
    Nramp; Natural resistance-associated macrophage protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    74375014..74386057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495773.2XP_006495836.1  

    Conserved Domains (2) summary
    TIGR01197
    Location:80480
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    pfam01566
    Location:102487
    Nramp; Natural resistance-associated macrophage protein
  2. XM_006495774.1XP_006495837.1  

    Conserved Domains (2) summary
    TIGR01197
    Location:1389
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    pfam01566
    Location:11396
    Nramp; Natural resistance-associated macrophage protein

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    74932506..74943551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)