Nr1i2 nuclear receptor subfamily 1, group I, member 2 [Mus musculus] - Gene

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Summary

Official Symbol: Nr1i2provided by MGI
Official Full Name: nuclear receptor subfamily 1, group I, member 2provided by MGI
Primary source: MGI:1337040
See related: Ensembl:ENSMUSG00000022809; Vega:OTTMUSG00000023687
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PXR; SXR; PXR1; mPXR; PXR.1; PXR.2

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Genomic context

Location :: 16 B3; 16

Sequence :: Chromosome: 16; NC_000082.6 (38248349..38294824, complement)

See Nr1i2 in Epigenomics, MapViewer

Chromosome 16 - NC_000082.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that pregnane X receptor (PXR) deficiency did not alter plasma lipid levels in apoE(-/-) mice, but PXR(-/-)apoE(-/-) mice had significantly decreased atherosclerotic cross-sectional lesion area.
Title: Deficiency of PXR decreases atherosclerosis in apoE-deficient mice.
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice
Title: Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.
These results demonstrate a novel and unsuspected role for steroid and xenobiotic receptor (SXR) signaling in the B-1 cell compartment, establish SXR as a tumor suppressor in B-1 cells
Title: B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR.
PXR prevented choelsterol gallstone disease via its coordinate regulation of the biosynthesis and transport of bile salts in the liver and intestine.
Title: PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts.
analysis of hepatic transcriptional responses of wild-type (PXR(+/+)) and pregnane X receptor-knockout (PXR(-/-)) mice after 96 h exposure to CMP013, an inhibitor of beta-secretase
Title: A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity.
investigation of role of PXR in regulation of gene expression regulation of placental drug transporters; results suggest a tissue-specific role for gene regulation by PXR
Title: Gestational and pregnane X receptor-mediated regulation of placental ATP-binding cassette drug transporters in mice.
Pregnane X receptor promotes bone formation and suppresses bone resorption, thus cementing a role for pregnane X receptor as a key regulator of bone homeostasis.
Title: Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption.
studies demonstrate that the variant PXR isoform, mPXR(Delta171-211), has a distinct repressive function from mPXR(431) in regulating genes encoding important drug metabolizing enzymes and transport proteins
Title: The alternatively spliced murine pregnane X receptor isoform, mPXR(delta171-211) exhibits a repressive action.
PXR activation inhibits T cell proliferation and interferon (IFN)-gamma production and expression in vitro.
Title: Modulation of T lymphocyte function by the pregnane X receptor.
loss of pregnane X receptor (PXR) potentiates lipopolysaccharide/D-galactosamine-induced hepatocyte apoptosis and liver injury
Title: The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury.

Submit: New GeneRIF Correction See all (51)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation
Targeted (knock-in) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:201839	BioGRID:108403	ESR1	BioGRID	PubMed	Reconstituted Complex
BioGRID:201839	BioGRID:113841	NCOA3	BioGRID	PubMed	Reconstituted Complex
BioGRID:201839	BioGRID:201709	Ncoa3	BioGRID	PubMed	Two-hybrid
BioGRID:201839	BioGRID:203040	Rxrg	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
drug binding	ISO Inferred from Sequence Orthology more info
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
steroid hormone receptor activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
drug export	ISO Inferred from Sequence Orthology more info
exogenous drug catabolic process	ISO Inferred from Sequence Orthology more info
intracellular receptor mediated signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
steroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: nuclear receptor subfamily 1 group I member 2

Names: nuclear receptor subfamily 1 group I member 2; Pregnane X receptor; orphan nuclear receptor PXR

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098404.1 → NP_001091874.1 nuclear receptor subfamily 1 group I member 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate, in-frame, downstream acceptor splice site at one of the coding exons compared to transcript variant 1, resulting in an isoform (2, also known as PXR.2) that is missing a 41 aa segment compared to isoform 1.

Source sequence(s)

AF031814, AI595758, AI746915, AK018630, CK383398

UniProtKB/Swiss-Prot

O54915

Conserved Domains (2) summary

cd06934
Location:140 – 384
Blast Score: 939

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cl02596
Location:37 – 124
Blast Score: 422

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_010936.3 → NP_035066.1 nuclear receptor subfamily 1 group I member 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1, also known as PXR.1).

Source sequence(s)

AI595758, AI746915, AK018630, CK383398

Consensus CDS

CCDS28164.1

UniProtKB/Swiss-Prot

O54915

UniProtKB/TrEMBL

Q0P525

Related

ENSMUSP00000023504, OTTMUSP00000027962, ENSMUST00000023504, OTTMUST00000057839

Conserved Domains (2) summary

cd06934
Location:140 – 425
Blast Score: 892

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cl02596
Location:37 – 124
Blast Score: 427

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000082.6 Reference GRCm38 C57BL/6J

Range

38248349..38294824, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000038.1 Alternate Mm_Celera

Range

38657356..38703953, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC154284.1	None
genomic	AC154809.2 (123666..160191)	None
genomic	CH466521.1	EDK97971.1	mixed
mRNA	AF031814.1	AAC39964.1
mRNA	AI595758.1	None	C57BL
mRNA	AI746915.1	None	C57BL
mRNA	AK011108.1	BAB27404.1	C57BL/6J
mRNA	AK018630.1	BAB31316.1	C57BL/6J
mRNA	BC120796.1	AAI20797.1
mRNA	BC137780.1	AAI37781.1
mRNA	CK383398.1	None

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O54915.1	GenPept	UniProtKB/Swiss-Prot:O54915
Q0P525	GenPept	UniProtKB/TrEMBL:Q0P525
Q9CRZ0	GenPept	UniProtKB/TrEMBL:Q9CRZ0