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Npr1 natriuretic peptide receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 18160, updated on 22-May-2016
Official Symbol
Npr1provided by MGI
Official Full Name
natriuretic peptide receptor 1provided by MGI
Primary source
MGI:MGI:97371
See related
Ensembl:ENSMUSG00000027931 Vega:OTTMUSG00000029513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GC-A; NPRA; Pndr; NPR-A; AI893888
Orthologs
Location:
3 F1; 3 39.23 cM
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (90450592..90465928, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (90254514..90269788, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 (fatty acid transporter), member 3 Neighboring gene integrator complex subunit 3 Neighboring gene nuclear encoded tRNA methionine 11 (anticodon CAT) Neighboring gene interleukin enhancer binding factor 2 Neighboring gene SNAP-associated protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
    Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
    Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Physiological factors, organism-specific biosystem (from REACTOME)
    Physiological factors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, organism-specific biosystem (from WikiPathways)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
    Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cGMP signaling, organism-specific biosystem (from KEGG)
    cGMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • cGMP signaling, conserved biosystem (from KEGG)
    cGMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cyclic GMP biosynthesis, organism-specific biosystem (from BIOCYC)
    cyclic GMP biosynthesis, organism-specific biosystemcGMP synthesis is catalyzed by guanylyl (guanylate) cyclases, a family of enzymes that catalyze the conversion of GTP to cGMP. The family comprises both membrane-bound and soluble isoforms that are e...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117511

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
guanylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
guanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
hormone binding ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
natriuretic peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
natriuretic peptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor guanylyl cyclase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood vessel size IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
atrial natriuretic peptide receptor 1
Names
ANP-A
ANPR-A
Nppa receptor
atrial natriuretic peptide receptor type A
guanylate cyclase A
guanylyl cyclase-A
NP_032753.5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008727.5NP_032753.5  atrial natriuretic peptide receptor 1 precursor

    See identical proteins and their annotated locations for NP_032753.5

    Status: VALIDATED

    Source sequence(s)
    AK135008, CJ065787, L31932
    Consensus CDS
    CCDS17529.1
    UniProtKB/Swiss-Prot
    P18293
    UniProtKB/TrEMBL
    Q2TAY4, Q3UY30
    Related
    ENSMUSP00000029540, OTTMUSP00000037824, ENSMUST00000029540, OTTMUST00000073130
    Conserved Domains (7) summary
    cd06385
    Location:32439
    PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
    cd07302
    Location:8711047
    CHD; cyclase homology domain
    smart00219
    Location:543797
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:8361025
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam01094
    Location:50411
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:810857
    HNOBA; Heme NO binding associated
    cd14042
    Location:530803
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    90450592..90465928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501114.1XP_006501177.1  

    Conserved Domains (2) summary
    pfam01094
    Location:50411
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:32439
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RNA

  1. XR_375494.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    90488131..90503567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)