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Nppc natriuretic peptide type C [ Mus musculus (house mouse) ]

Gene ID: 18159, updated on 8-May-2016
Official Symbol
Nppcprovided by MGI
Official Full Name
natriuretic peptide type Cprovided by MGI
Primary source
MGI:MGI:97369
See related
Ensembl:ENSMUSG00000026241 Vega:OTTMUSG00000048101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CNP; lbab
Summary
This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]
Orthologs
Location:
1 D; 1 43.98 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (86666293..86670573, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (88562866..88567147, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 7B Neighboring gene predicted gene, 41908 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 Neighboring gene predicted gene, 32879 Neighboring gene ribosomal protein L6 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC130574

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hormone activity ISO
Inferred from Sequence Orthology
more info
 
neuropeptide hormone activity TAS
Traceable Author Statement
more info
PubMed 
peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
animal organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cGMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
growth plate cartilage chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth plate cartilage chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oocyte maturation ISO
Inferred from Sequence Orthology
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor guanylyl cyclase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of blood vessel size IEA
Inferred from Electronic Annotation
more info
 
regulation of cAMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cGMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
single organism reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
C-type natriuretic peptide
Names
natriuretic peptide precursor C
natriuretic peptide precursor type C

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010933.5NP_035063.1  C-type natriuretic peptide preproprotein

    See identical proteins and their annotated locations for NP_035063.1

    Status: REVIEWED

    Source sequence(s)
    AC158132, AK036176, BY718381
    Consensus CDS
    CCDS15123.1
    UniProtKB/Swiss-Prot
    Q61839
    UniProtKB/TrEMBL
    Q544K5
    Related
    ENSMUSP00000027449, OTTMUSP00000067450, ENSMUST00000027449, OTTMUST00000123581
    Conserved Domains (1) summary
    pfam00212
    Location:94126
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    86666293..86670573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    89636055..89640335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)