Npm1 nucleophosmin 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Npm1provided by MGI
Official Full Name: nucleophosmin 1provided by MGI
Primary source: MGI:106184
Locus tag: RP23-323L8.2
See related: Ensembl:ENSMUSG00000057113; Vega:OTTMUSG00000005395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B23; Npm; NO38

Genomic context

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Location :: 11 A4; 11

Sequence :: Chromosome: 11; NC_000077.6 (33152498..33163206, complement)

See Npm1 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The B23 regulates neuronal survival by preventing SIAH1-GAPDH death signaling under stress-induced conditions in the brain.
Title: S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1-GAPDH death cascade.
the aberrant feed-forward pathway that keeps eIF4E and C/EBPalphap30 elevated in NPM1(+/-) cells contributes to the MDS phenotype associated with NPM1 deficiency.
Title: Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.
level of Npm1 expression has a role in regulating hematopoietic stem cell numbers in the bone marrow.
Title: Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells.
A dual function of NPM1 in M-CSF-differentiated macrophages.
Title: Fine-tuning nucleophosmin in macrophage differentiation and activation.
propose that although the t(2;5) simultaneously reduces NPM1 allelic dosage and creates the NPM-ALK fusion protein, the two events do not cooperate in the pathogenesis of anaplastic large cell lymphoma in our mouse model
Title: Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis.
The Tpt1-Npm1 complex as a novel marker for highly proliferating cells, and offer further insight into the network that controls cellular fate.
Title: Translationally controlled tumor protein interacts with nucleophosmin during mitosis in ES cells.
data show that neoplastic mast cells (MC) express IL-9 receptors, that IL-9 and NPM-ALK upregulate MC-production in vivo, and that both'hits' act in concert to induce a mastocytosis-like disease in mice
Title: Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice.
Data show that Oct4, Sox2 and Nanog individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination.
Title: Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination.
the Cdk2/Cdk4/NPM pathway is a major guardian of centrosome dysfunction and genomic integrity.
Title: Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.
Inhibiting Crm1 in early metaphase causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.
Title: Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.

Submit: New GeneRIF Correction See all (33)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation
Targeted (Reporter) (1) 1 citation
Gene trapped (2) 1 citation
Targeted (knock-in) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
AL772409.4	NP_034979.2	Myc	BIND	PubMed	Myc interacts with the Npm1 (B23) promoter.
BioGRID:201823	BioGRID:198383	Brca1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:198644	Cdk2	BioGRID	PubMed	Biochemical Activity
BioGRID:201823	BioGRID:198654	Cdkn2a	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:201823	BioGRID:240650	Cpsf6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:222684	Ddx1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:199086	Ddx5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:199088	Dhx9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:212703	Ebpl	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:199387	Eef2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:206088	Fbxw7	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:201823	BioGRID:200357	Hnrnpa1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:207865	Hnrnph2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:201706	Ncl	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:201817	Nup50	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:201879	Nup62	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:106652	PARP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201823	BioGRID:115350	PARP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201823	BioGRID:197999	Parp2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201823	BioGRID:202951	Rock2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:201823	BioGRID:204356	Rpl13a	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:202971	Rpl22	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:202974	Rpl27	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:212515	Rpl4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:433810	Rpl5	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:201823	BioGRID:202988	Rpl7	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:201823	BioGRID:205106	Rps3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201823	BioGRID:203010	Rps3a1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:203012	Rps5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:203013	Rps6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:203016	Rps7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:203188	Srsf2	BioGRID	PubMed	Co-localization
BioGRID:201823	BioGRID:204420	Sumo1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201823	BioGRID:228466	Sumo2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201823	BioGRID:203358	Sumo3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201823	BioGRID:204015	Tcf3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201823	BioGRID:204323	Trp53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201823	BioGRID:204524	Vim	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chromosome Maintenance, organism-specific biosystem (from REACTOME)
Chromosome Maintenance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem (from REACTOME)
Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleosome assembly, organism-specific biosystem (from REACTOME)
Nucleosome assembly, organism-specific biosystemcomputationally inferred pathway (not manually curated)
mRNA processing, organism-specific biosystem (from WikiPathways)
mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

General gene information

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Markers

Npm1-rs (e-PCR), detects polymorphism
- UniSTS:144053

Homology

Homologs of the Npm1 gene: The Npm1 gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	ISO Inferred from Sequence Orthology more info
NF-kappaB binding	ISO Inferred from Sequence Orthology more info
RNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA binding	ISO Inferred from Sequence Orthology more info
Tat protein binding	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
histone binding	ISO Inferred from Sequence Orthology more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
rRNA binding	IDA Inferred from Direct Assay more info	PubMed
ribosomal large subunit binding	ISO Inferred from Sequence Orthology more info	PubMed
ribosomal small subunit binding	ISO Inferred from Sequence Orthology more info	PubMed
transcription coactivator activity	ISO Inferred from Sequence Orthology more info
unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
DNA repair	ISO Inferred from Sequence Orthology more info
cell aging	ISO Inferred from Sequence Orthology more info
cell growth	IDA Inferred from Direct Assay more info	PubMed
cell volume homeostasis	IDA Inferred from Direct Assay more info	PubMed
cell volume homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
centrosome cycle	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
nucleosome assembly	ISO Inferred from Sequence Orthology more info
positive regulation of DNA metabolic process	ISO Inferred from Sequence Orthology more info
positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cellular biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cellular biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of centrosome duplication	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein destabilization	IMP Inferred from Mutant Phenotype more info
protein homooligomerization	ISO Inferred from Sequence Orthology more info
protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
protein localization	ISO Inferred from Sequence Orthology more info
protein oligomerization	ISO Inferred from Sequence Orthology more info	PubMed
rRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
rRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of DNA damage response, signal transduction by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of centriole replication	ISO Inferred from Sequence Orthology more info
regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info
regulation of endoribonuclease activity	ISO Inferred from Sequence Orthology more info
regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
response to stress	ISO Inferred from Sequence Orthology more info
ribosomal large subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed
ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
ribosomal large subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed
ribosomal small subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
ribosomal small subunit export from nucleus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info	PubMed
centrosome	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
granular component	IDA Inferred from Direct Assay more info	PubMed
large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
nuclear speck	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleolus	ISO Inferred from Sequence Orthology more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleophosmin

Names: nucleophosmin; numatrin; nucleolar protein NO38; nucleolar phosphoprotein B23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252260.1 → NP_001239189.1 nucleophosmin isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC089546, BU513690, CA540276, CX567338

UniProtKB/TrEMBL

Q5SQB7

Conserved Domains (1) summary

pfam03066
Location:13 – 103
Blast Score: 384

Nucleoplasmin; Nucleoplasmin
NM_001252261.1 → NP_001239190.1 nucleophosmin isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two exons but has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC090843, CA540276

Consensus CDS

CCDS56765.1

UniProtKB/TrEMBL

Q5BL09

UniProtKB/TrEMBL

Q9DAY9

Related

ENSMUSP00000104978, OTTMUSP00000005573, ENSMUST00000109354, OTTMUST00000012026

Conserved Domains (1) summary

pfam03066
Location:13 – 116
Blast Score: 440

Nucleoplasmin; Nucleoplasmin
NM_008722.3 → NP_032748.1 nucleophosmin isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK165860, CA540276, CX567338

Consensus CDS

CCDS24532.1

UniProtKB/TrEMBL

Q5SQB7

UniProtKB/Swiss-Prot

Q61937

Related

ENSMUSP00000075067, OTTMUSP00000005572, ENSMUST00000075641, OTTMUST00000012025

Conserved Domains (1) summary

pfam03066
Location:13 – 116
Blast Score: 447

Nucleoplasmin; Nucleoplasmin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

33152498..33163206, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

35564818..35575474, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01092141.1	None
genomic	AAHY01092142.1 (12954..15875)	None
genomic	AL772409.4 (30517..41225)	None
genomic	CH466604.2	EDL23744.1	mixed
mRNA	AK005420.1	BAB24014.1	C57BL/6J
mRNA	AK005498.1	None	C57BL/6J
mRNA	AK028253.1	BAC25844.1	C57BL/6J
mRNA	AK028370.1	BAC25910.1	C57BL/6J
mRNA	AK088923.1	BAC40655.1	NOD
mRNA	AK135517.1	BAE22562.1	C57BL/6J
mRNA	AK145124.1	BAE26248.1
mRNA	AK145813.1	BAE26667.1	C57BL/6J
mRNA	AK150164.1	BAE29354.1	C57BL/6J
mRNA	AK153901.1	BAE32244.1	NOD
mRNA	AK165860.1	BAE38420.1
mRNA	AK184065.1	None
mRNA	BC054755.1	AAH54755.1	C57BL/6
mRNA	BC085278.1	AAH85278.1	C57BL/6J
mRNA	BC089546.1	AAH89546.1
mRNA	BC090843.1	AAH90843.1	C57BL/6
mRNA	BC092378.1	AAH92378.1	C57BL/6
mRNA	BU513690.1	None
mRNA	CA540276.1	None	C57BL/6J
mRNA	CX567338.1	None	C57BL/6
mRNA	GU214027.1	ADA57701.1	C57BL/6
mRNA	M33212.1	AAA39801.1