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Npm1 nucleophosmin 1 [ Mus musculus (house mouse) ]

Gene ID: 18148, updated on 27-Sep-2014
Official Symbol
Npm1provided by MGI
Official Full Name
nucleophosmin 1provided by MGI
Primary source
MGI:MGI:106184
Locus tag
RP23-323L8.2
See related
Ensembl:ENSMUSG00000057113; Vega:OTTMUSG00000005395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B23; Npm; NO38
See Npm1 in Epigenomics, MapViewer
Location:
11 A4; 11
Exon count:
12
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (33152498..33163206, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4, pseudogene 4 Neighboring gene fibroblast growth factor 18 Neighboring gene predicted gene 12115 Neighboring gene T cell leukemia, homeobox 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102162, MGC107291

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone binding ISO
Inferred from Sequence Orthology
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA repair ISO
Inferred from Sequence Orthology
more info
 
cell aging ISO
Inferred from Sequence Orthology
more info
 
cell growth IDA
Inferred from Direct Assay
more info
PubMed 
cell volume homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cell volume homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of centrosome duplication IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization ISO
Inferred from Sequence Orthology
more info
 
protein oligomerization ISO
Inferred from Sequence Orthology
more info
PubMed 
rRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
rRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA damage response, signal transduction by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of eIF2 alpha phosphorylation by dsRNA ISO
Inferred from Sequence Orthology
more info
 
regulation of endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
regulation of endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
response to stress ISO
Inferred from Sequence Orthology
more info
 
ribosomal large subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
granular component IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nucleophosmin
Names
nucleophosmin
numatrin
nucleolar protein NO38
nucleolar phosphoprotein B23

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252260.1NP_001239189.1  nucleophosmin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC089546, BU513690, CA540276, CX567338
    UniProtKB/TrEMBL
    Q5SQB7
    Conserved Domains (1) summary
    pfam03066
    Location:13106
    Nucleoplasmin; Nucleoplasmin
  2. NM_001252261.1NP_001239190.1  nucleophosmin isoform 3

    See proteins identical to NP_001239190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons but has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC090843, CA540276
    Consensus CDS
    CCDS56765.1
    UniProtKB/TrEMBL
    Q5BL09
    UniProtKB/TrEMBL
    Q9DAY9
    Related
    ENSMUSP00000104978, OTTMUSP00000005573, ENSMUST00000109354, OTTMUST00000012026
    Conserved Domains (1) summary
    pfam03066
    Location:13119
    Nucleoplasmin; Nucleoplasmin
  3. NM_008722.3NP_032748.1  nucleophosmin isoform 1

    See proteins identical to NP_032748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK165860, CA540276, CX567338
    Consensus CDS
    CCDS24532.1
    UniProtKB/TrEMBL
    Q5SQB7
    UniProtKB/Swiss-Prot
    Q61937
    Related
    ENSMUSP00000075067, OTTMUSP00000005572, ENSMUST00000075641, OTTMUST00000012025
    Conserved Domains (1) summary
    pfam03066
    Location:13119
    Nucleoplasmin; Nucleoplasmin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    33152498..33163206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514578.1XP_006514641.1  

    See proteins identical to XP_006514641.1

    UniProtKB/TrEMBL
    Q9DAY9
    Conserved Domains (1) summary
    pfam03066
    Location:13119
    Nucleoplasmin; Nucleoplasmin

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    35564818..35575474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)