sad-1 Serine/threonine kinase SAD-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: sad-1
Gene description: Serine/threonine kinase SAD-1
Primary source: WormBase:WBGene00004719
Locus tag: CELE_F15A2.6
See related: AllianceGenome:WB:WBGene00004719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables tau-protein kinase activity. Involved in several processes, including regulation of axon extension; synapse organization; and synaptic vesicle transport. Located in axon and dendrite. Is expressed in nervous system. Orthologous to several human genes including BRSK1 (BR serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See sad-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 17

Sequence:: Chromosome: X; NC_003284.9 (13487552..13500668, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data reveal a new and unprecedented role for 2 synapse assembly proteins, SAD-1 and SYD-2, in mediating UNC-16's organelle transport regulatory function.
Title: UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons.
crystals belonged to the monoclinic space group C2, with unit-cell parameters a = 205.4, b = 57.1, c = 71.7 A, beta = 106.1 degrees
Title: Preliminary crystallographic analysis of the kinase domain of SAD-1, a protein essential for presynaptic differentiation in Caenorhabditis elegans.
STRD-1 establishes neuronal polarity and organizes synaptic proteins in a complex with the SAD-1 kinase
Title: C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.
neuronal polarity and synaptic organization have distinct temporal requirements for SAD-1
Title: A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation.
Neurabin functions as a scaffold to facilitate SAD-1-mediated phosphorylation for substrates specific for restricting axonal fate during neuronal polarization.
Title: Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F15A2.6 (e-PCR)
- UniSTS:309765

F15A2.7 (e-PCR)
- UniSTS:318102

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axo-dendritic transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in presynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine kinase SAD-1

NP_001076760.1

Confirmed by transcript evidence

NP_001076761.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13487552..13500668 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001083292.4 → NP_001076761.1 Serine/threonine kinase SAD-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076761.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19469

Conserved Domains (3) summary

smart00220
Location:47 → 298

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:327 → 379

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:45 → 298

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
NM_001083291.5 → NP_001076760.1 Serine/threonine kinase SAD-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076760.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A3FPL0, Q19469, Q9BMN6

Conserved Domains (3) summary

smart00220
Location:47 → 298

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:327 → 379

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:45 → 298

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2