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DRD3 dopamine receptor D3 [ Homo sapiens (human) ]

Gene ID: 1814, updated on 23-Oct-2014
Official Symbol
DRD3provided by HGNC
Official Full Name
dopamine receptor D3provided by HGNC
Primary source
HGNC:HGNC:3024
See related
Ensembl:ENSG00000151577; HPRD:00540; MIM:126451; Vega:OTTHUMG00000159334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D3DR; ETM1; FET1
Summary
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
See DRD3 in Epigenomics, MapViewer
Location:
3q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (114128710..114199407, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113847499..113918254, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene queuine tRNA-ribosyltransferase domain containing 1 Neighboring gene histone cluster 1, H2bj pseudogene Neighboring gene KIAA1539 pseudogene Neighboring gene zinc finger protein 80

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Hereditary essential tremor 1
MedGen: C1860861 OMIM: 190300 GeneReviews: Not available
Compare labs
Schizophrenia
MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog
Genome-wide association study of the five-factor model of personality in young Korean women.
NHGRI GWA Catalog
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Dopamine receptors, organism-specific biosystem (from REACTOME)
    Dopamine receptors, organism-specific biosystemDopamine receptors play vital roles in processes such as the control of learning, motivation, fine motor control and modulation of neuroendocrine signaling (Giralt JA and Greengard P, 2004). Abnormal...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
    Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC149204, MGC149205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
dopamine binding IEA
Inferred from Electronic Annotation
more info
 
dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS
Inferred from Sequence or Structural Similarity
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
behavioral response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
behavioral response to cocaine ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
dopamine metabolic process IC
Inferred by Curator
more info
PubMed 
gastric emptying IEA
Inferred from Electronic Annotation
more info
 
learning NAS
Non-traceable Author Statement
more info
PubMed 
learning or memory NAS
Non-traceable Author Statement
more info
PubMed 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
musculoskeletal movement, spinal reflex action ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood volume by renin-angiotensin IEA
Inferred from Electronic Annotation
more info
 
regulation of cAMP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of circadian sleep/wake cycle, sleep IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dopamine uptake involved in synaptic transmission IC
Inferred by Curator
more info
PubMed 
regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT response to ethanol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to histamine IDA
Inferred from Direct Assay
more info
PubMed 
response to morphine ISS
Inferred from Sequence or Structural Similarity
more info
 
social behavior NAS
Non-traceable Author Statement
more info
PubMed 
synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
D(3) dopamine receptor
Names
D(3) dopamine receptor
essential tremor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008842.2 

    Range
    5001..75756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000796.5NP_000787.2  D(3) dopamine receptor isoform a

    See proteins identical to NP_000787.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the predominant transcript and encodes the longer isoform (a). Variants a, f and g encode the same isoform (a).
    Source sequence(s)
    AK292309, AY228458, BC095510
    Consensus CDS
    CCDS2978.1
    UniProtKB/TrEMBL
    A8K8E4
    UniProtKB/Swiss-Prot
    P35462
    UniProtKB/TrEMBL
    X5D2G4
    Related
    ENSP00000373169, ENST00000383673
    Conserved Domains (2) summary
    pfam00001
    Location:52383
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:44216
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx
  2. NM_001282563.2NP_001269492.1  D(3) dopamine receptor isoform a

    See proteins identical to NP_001269492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) differs in the 5' UTR compared to variant a. Variants a, f and g encode the same isoform (a).
    Source sequence(s)
    AK292309, BC095510
    Consensus CDS
    CCDS2978.1
    UniProtKB/TrEMBL
    A8K8E4
    UniProtKB/Swiss-Prot
    P35462
    UniProtKB/TrEMBL
    X5D2G4
    Related
    ENSP00000419402, OTTHUMP00000214909, ENST00000460779, OTTHUMT00000354699
    Conserved Domains (2) summary
    pfam00001
    Location:52383
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:44216
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx
  3. NM_001290809.1NP_001277738.1  D(3) dopamine receptor isoform a

    See proteins identical to NP_001277738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) has an additional internal exon in the 5' UTR, compared to variant a. Variants a, f and g encode the same isoform (a).
    Source sequence(s)
    AK292309, BC095510, BC128122
    Consensus CDS
    CCDS2978.1
    UniProtKB/TrEMBL
    A1A4V4
    UniProtKB/TrEMBL
    A8K8E4
    UniProtKB/Swiss-Prot
    P35462
    UniProtKB/TrEMBL
    X5D2G4
    Conserved Domains (2) summary
    pfam00001
    Location:52383
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:44216
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx
  4. NM_033663.5NP_387512.3  D(3) dopamine receptor isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) has split coding exons at the 3' end compared to the penultimate coding exon of variant a. This results in a shorter isoform (e) missing a 33 aa segment compared to isoform a.
    Source sequence(s)
    AK292309, AY228458, BC095510, L20469
    Consensus CDS
    CCDS33829.1
    UniProtKB/TrEMBL
    A8K8E4
    UniProtKB/TrEMBL
    E9PCM4
    UniProtKB/Swiss-Prot
    P35462
    Related
    ENSP00000295881, ENST00000295881
    Conserved Domains (2) summary
    pfam00001
    Location:52350
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:44216
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    114128710..114199407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247171.1XP_005247228.1  

    Related
    ENSP00000420662, OTTHUMP00000214910, ENST00000467632, OTTHUMT00000354700
    Conserved Domains (2) summary
    pfam00001
    Location:52383
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:44216
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx
  2. XM_006713522.1XP_006713585.1  

    Conserved Domains (2) summary
    pfam00001
    Location:52221
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:44216
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    111221547..111291849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    113810902..113881272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033658.1: Suppressed sequence

    Description
    NM_033658.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
  2. NM_033659.1: Suppressed sequence

    Description
    NM_033659.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_033660.1: Suppressed sequence

    Description
    NM_033660.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.