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Notch1 notch 1 [ Mus musculus (house mouse) ]

Gene ID: 18128, updated on 5-May-2013

Summary

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Official Symbol: Notch1provided by MGI
Official Full Name: notch 1provided by MGI
Primary source: MGI:97363
Locus tag: RP23-306D20.12-001
See related: Ensembl:ENSMUSG00000026923; Vega:OTTMUSG00000012795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: N1; Mis6; Tan1; lin-12; 9930111A19Rik

Genomic context

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Location :: 2 A3; 2 18.91 cM

Sequence :: Chromosome: 2; NC_000068.7 (26457902..26503822, complement)

See Notch1 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Maintenance of Gata3 protein levels by Myb and Notch signaling is linked to the ability to retain T-cell identity in response to PU.1.
Title: Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3.
Data suggest that the RBPjkappa-dependent Notch signaling in chondrocytes modulates the terminal stage of endochondral ossification and osteoarthritis (OA) development, representing an extracellular therapeutic target of OA.
Title: Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development.
Rbpj, a key nuclear effector in the Notch signaling pathway, plays an essential role in locus coeruleus neuron development in the mouse.
Title: Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus.
Data indicate the need to tightly regulate Notch signaling to expand normal hematopoietic stem cells (HSCs) populations for clinical applications.
Title: Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.
Data show that Notch1/Dll4-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment.
Title: LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.
Mib1 is a major component of the signal-sending cells required to provide Notch ligand activity for specifying neurons and glia in the spinal cord
Title: The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.
The peripheral vascular niches composed of endothelial cells and smooth muscle cells may predispose haematopoietic CD34(+)CD31(+) progenitors to differentiate into macrophages through the activation of the jagged-1/Notch-1 cascade.
Title: β(2)-Integrin and Notch-1 differentially regulate CD34(+)CD31(+) cell plasticity in vascular niches.
findings show Notch suppresses Nfat transactivation in chondrocytes and Notch and Nfatc1 regulate chondrocyte differentiation
Title: Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes.
The repressive effect of Lfng against Notch activities in neighbouring cells can sufficiently explain the synchronization in vivo.
Title: Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling.
This is the first demonstration that high levels of IL-7 antagonize Notch-1 signaling and suggest that IL-7 may affect T- versus B-lineage choice in the thymus.
Title: High levels of IL-7 cause dysregulation of thymocyte development.

Submit: New GeneRIF Correction See all (456)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (5) 1 citation
Targeted (other) (1) 1 citation
Chemically induced (ENU) (1) 1 citation
Targeted (knock-in) (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_032740.2	NP_690879.1	Dner	BIND	PubMed	DNER interacts with Notch1. This interaction was modeled on a demonstrated interaction between DNER from an unspecified species and mouse Notch1.
NP_032740.2	NP_032078.1	Dtx1	BIND	PubMed	MDTX1 interacts with Notch1.
NP_032740.2	NP_076231.1	Dtx2	BIND	PubMed	MDTX2 interacts with Notch1.
NP_032740.2	NP_808489.3	Ep300	BIND	PubMed	p300 interacts with Notch1. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and mouse Notch1.
NP_032740.2	XP_192925.2	Itch	BIND	PubMed	Notch1 is unbiquitinated by Itch.
NP_032740.2	NP_033061.1	Rbpj	BIND	PubMed	RBP-J interacts with Notch1.
BioGRID:201808	BioGRID:199232	Dll1	BioGRID	PubMed	Reconstituted Complex
BioGRID:201808	BioGRID:109257	GZMB	BioGRID	PubMed	Biochemical Activity
BioGRID:201808	BioGRID:108918	KAT2A	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:201808	BioGRID:114375	KAT2B	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:201808	BioGRID:199867	Kat2a	BioGRID	PubMed	Two-hybrid
BioGRID:201808	BioGRID:202042	Kat2b	BioGRID	PubMed	Two-hybrid
BioGRID:201808	BioGRID:114202	NUMB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201808	BioGRID:201877	Numb	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201808	BioGRID:202414	Psen1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201808	BioGRID:202415	Psen2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201808	BioGRID:202832	Rbpj	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201808	BioGRID:211860	Smarcd3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201808	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201808	BioGRID:208312	Wdr12	BioGRID	PubMed	Reconstituted Complex
BioGRID:201808	BioGRID:106828	XIAP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Pathways from BioSystems

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Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem (from REACTOME)
Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Constitutive Signaling by NOTCH1 HD Domain Mutants, organism-specific biosystem (from REACTOME)
Constitutive Signaling by NOTCH1 HD Domain Mutants, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, organism-specific biosystem (from REACTOME)
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
Dorso-ventral axis formation, organism-specific biosystem
Dorso-ventral axis formation
Dorso-ventral axis formation, conserved biosystem (from KEGG)
Dorso-ventral axis formation, conserved biosystem
Dorso-ventral axis formation
FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Heart Development, organism-specific biosystem (from WikiPathways)
Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling, organism-specific biosystem (from REACTOME)
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch signaling pathway, organism-specific biosystem (from KEGG)
Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch signaling pathway, conserved biosystem (from KEGG)
Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch-HLH transcription pathway, organism-specific biosystem (from REACTOME)
Notch-HLH transcription pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
Pre-NOTCH Expression and Processing, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pre-NOTCH Processing in Golgi, organism-specific biosystem (from REACTOME)
Pre-NOTCH Processing in Golgi, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pre-NOTCH Processing in the Endoplasmic Reticulum, organism-specific biosystem (from REACTOME)
Pre-NOTCH Processing in the Endoplasmic Reticulum, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pre-NOTCH Transcription and Translation, organism-specific biosystem (from REACTOME)
Pre-NOTCH Transcription and Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Prion diseases, organism-specific biosystem (from KEGG)
Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Prion diseases, conserved biosystem (from KEGG)
Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Ptf1a related regulatory pathway, organism-specific biosystem (from WikiPathways)
Ptf1a related regulatory pathway, organism-specific biosystemBy summarizing published data together with our own results, this pathway shows a complicated relationships between transcriptional factors, miRNAs and some functional genes which are correlated toge...
Regulation of beta-cell development, organism-specific biosystem (from REACTOME)
Regulation of beta-cell development, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, organism-specific biosystem (from REACTOME)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH, organism-specific biosystem (from REACTOME)
Signaling by NOTCH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1 HD Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1 HD Domain Mutants in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1 in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, organism-specific biosystemcomputationally inferred pathway (not manually curated)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

UniSTS:265729 (e-PCR)
- UniSTS:265729

Notch1 (e-PCR), detects polymorphism
- UniSTS:265729

RH134624 (e-PCR)
- UniSTS:217903

Notch1 (e-PCR), detects polymorphism
- UniSTS:465460

Notch1 (e-PCR), detects polymorphism
- UniSTS:465461

Notch1 (e-PCR), detects polymorphism
- UniSTS:259639

Notch1 (e-PCR), detects polymorphism
- UniSTS:516409

PMC85812P1 (e-PCR)
- UniSTS:273494

Notch1 (e-PCR), detects polymorphism
- UniSTS:527454

Notch1 (e-PCR), detects polymorphism
- UniSTS:144044

Notch1 (e-PCR), detects polymorphism
- UniSTS:144045

Notch1 (e-PCR), detects polymorphism
- UniSTS:496832

Notch1 (e-PCR), detects polymorphism
- UniSTS:528855

Notch1 (e-PCR), detects polymorphism
- UniSTS:186340

D2Mit151 (e-PCR), detects polymorphism
- UniSTS:129012

Homology

Homologs of the Notch1 gene: The Notch1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, and mosquito.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	IDA Inferred from Direct Assay more info	PubMed
calcium ion binding	IEA Inferred from Electronic Annotation more info
chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
core promoter binding	IDA Inferred from Direct Assay more info
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
Notch signaling involved in heart development	IGI Inferred from Genetic Interaction more info
Notch signaling involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
Notch signaling involved in heart development	ISO Inferred from Sequence Orthology more info
Notch signaling pathway	IC Inferred by Curator more info	PubMed
Notch signaling pathway	IDA Inferred from Direct Assay more info
Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
Notch signaling pathway	ISO Inferred from Sequence Orthology more info
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
anagen	IMP Inferred from Mutant Phenotype more info	PubMed
aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
arterial endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
astrocyte differentiation	ISO Inferred from Sequence Orthology more info
atrioventricular node development	IMP Inferred from Mutant Phenotype more info
atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
auditory receptor cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
axonogenesis	IDA Inferred from Direct Assay more info	PubMed
axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
cardiac atrium morphogenesis	IMP Inferred from Mutant Phenotype more info
cardiac chamber formation	IMP Inferred from Mutant Phenotype more info
cardiac epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
cardiac left ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info
cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info
cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info
cardiac right atrium morphogenesis	IMP Inferred from Mutant Phenotype more info
cardiac right ventricle formation	IMP Inferred from Mutant Phenotype more info	PubMed
cardiac septum morphogenesis	IMP Inferred from Mutant Phenotype more info
cardiac vascular smooth muscle cell development	IMP Inferred from Mutant Phenotype more info
cardiac ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info
cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
cell migration involved in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info
cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
compartment pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
coronary artery morphogenesis	IMP Inferred from Mutant Phenotype more info
coronary vein morphogenesis	IMP Inferred from Mutant Phenotype more info
determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
embryo development	ISO Inferred from Sequence Orthology more info
embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
endocardial cell differentiation	IMP Inferred from Mutant Phenotype more info
endocardial cushion morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
endocardium development	IMP Inferred from Mutant Phenotype more info	PubMed
endocardium morphogenesis	IMP Inferred from Mutant Phenotype more info
endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
epithelial to mesenchymal transition involved in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info	PubMed
forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
growth involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info
hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
heart development	IMP Inferred from Mutant Phenotype more info	PubMed
heart development	ISO Inferred from Sequence Orthology more info
heart looping	IGI Inferred from Genetic Interaction more info	PubMed
heart trabecula morphogenesis	IMP Inferred from Mutant Phenotype more info
humoral immune response	IGI Inferred from Genetic Interaction more info	PubMed
in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
inflammatory response to antigenic stimulus	IGI Inferred from Genetic Interaction more info	PubMed
interleukin-4 secretion	IGI Inferred from Genetic Interaction more info	PubMed
keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
liver development	IMP Inferred from Mutant Phenotype more info	PubMed
lung development	IMP Inferred from Mutant Phenotype more info	PubMed
mesenchymal cell development	IMP Inferred from Mutant Phenotype more info	PubMed
mitral valve formation	ISO Inferred from Sequence Orthology more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell death	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
negative regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of oligodendrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of ossification	IMP Inferred from Mutant Phenotype more info
negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of pro-B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
neuron fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
osteoblast fate commitment	NAS Non-traceable Author Statement more info	PubMed
pericardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info
positive regulation of JAK-STAT cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of astrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info
positive regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of ephrin receptor signaling pathway	IC Inferred by Curator more info	PubMed
positive regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info
positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
positive regulation of glial cell differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of keratinocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription of Notch receptor target	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription of Notch receptor target	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
prostate gland epithelium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
regulation of cardioblast proliferation	ISO Inferred from Sequence Orthology more info
regulation of cell adhesion involved in heart morphogenesis	IC Inferred by Curator more info	PubMed
regulation of cell migration	IMP Inferred from Mutant Phenotype more info
regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
regulation of developmental process	IEA Inferred from Electronic Annotation more info
regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info
regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	IMP Inferred from Mutant Phenotype more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
response to muramyl dipeptide	IDA Inferred from Direct Assay more info
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	IMP Inferred from Mutant Phenotype more info	PubMed
skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info
somatic stem cell division	IDA Inferred from Direct Assay more info	PubMed
somatic stem cell division	IGI Inferred from Genetic Interaction more info	PubMed
spermatogenesis	ISO Inferred from Sequence Orthology more info
sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
vasculogenesis involved in coronary vascular morphogenesis	IMP Inferred from Mutant Phenotype more info
venous endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info
ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info
ventricular trabecula myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	ISO Inferred from Sequence Orthology more info
MAML1-RBP-Jkappa- ICN1 complex	ISO Inferred from Sequence Orthology more info
acrosomal vesicle	ISO Inferred from Sequence Orthology more info
cell surface	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	IC Inferred by Curator more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IMP Inferred from Mutant Phenotype more info
nucleus	ISO Inferred from Sequence Orthology more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurogenic locus notch homolog protein 1

Names: neurogenic locus notch homolog protein 1; mT14; p300; Motch A; Notch gene homolog 1; major type A protein; transmembrane receptor Notch1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008714.3 → NP_032740.3 neurogenic locus notch homolog protein 1 precursor

Status: VALIDATED

Source sequence(s)

BC138441, BF318436, BY233933

Consensus CDS

CCDS15806.1

UniProtKB/Swiss-Prot

Q01705

Related

ENSMUSP00000028288, OTTMUSP00000013754, ENSMUST00000028288, OTTMUST00000030656

Conserved Domains (9) summary

cd00054
Location:869 – 905
Blast Score: 111

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1912 – 2024
Blast Score: 260

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam11936
Location:2453 – 2517
Blast Score: 202

DUF3454; Domain of unknown function (DUF3454)

pfam06247
Location:1241 – 1397
Blast Score: 92

Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28

pfam06816
Location:1566 – 1622
Blast Score: 261

NOD; NOTCH protein

pfam07684
Location:1660 – 1721
Blast Score: 114

NODP; NOTCH protein

smart00004
Location:1442 – 1479
Blast Score: 123

NL; Domain found in Notch and Lin-12

pfam00066
Location:1485 – 1522
Blast Score: 135

Notch; LNR domain

pfam12796
Location:1922 – 2015
Blast Score: 180

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p1 C57BL/6J

Range

26457902..26503822, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

26175736..26221759, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01014792.1 (38575..72331)	None
genomic	AAHY01014793.1	None
genomic	AB100603.1	BAC77038.1	C.B17
		BAC77039.1	C.B17
		BAC77040.1	C.B17
genomic	AL732541.11 (22502..68422)	None
genomic	CH466542.1	EDL08321.1	mixed
genomic	CS419139.1	CAL48809.1
mRNA	AB101624.1	None	STS
mRNA	AB101625.1	None	STS
mRNA	AB101626.1	None	STS
mRNA	AB101627.1	None	STS
mRNA	AB101628.1	None	STS
mRNA	AB101629.1	None	STS
mRNA	AB101630.1	None	STS
mRNA	AB101631.1	None	STS
mRNA	AB101634.1	None	C.B17
mRNA	AB101636.1	None	C.B-17scid
mRNA	AB101637.1	None	C.B-17scid
mRNA	AF508809.1	AAM28905.1	BALB/c
mRNA	AJ238029.1	CAB40733.1	DBA/2
mRNA	AK004408.1	None	C57BL/6J
mRNA	AK042197.1	BAC31194.1	C57BL/6J
mRNA	AK054089.1	None	C57BL/6J
mRNA	AK079454.1	None	C57BL/6J
mRNA	AK090118.1	None
mRNA	AK149054.1	None	C57BL/6J
mRNA	AK154528.1	BAE32653.1	NOD
mRNA	AK157475.1	BAE34095.1	NOD
mRNA	BC010325.1	None	CZECHII
mRNA	BC058427.1	None	C57BL/6
mRNA	BC138441.1	AAI38442.1
mRNA	BC138442.1	AAI38443.1
mRNA	BF318436.1	None	C57BL/6J
mRNA	BY233933.1	None	C57BL/6J
mRNA	L02613.2	AAK14898.1	CD-1
mRNA	X68278.1	CAA48339.1	CBA x C57BL F1
mRNA	X82562.1	CAA57909.1
mRNA	Z11886.1	CAA77941.1
mRNA	Z21925.1	None	CD-1