Format

Send to:

Choose Destination

Nos3 nitric oxide synthase 3, endothelial cell [ Mus musculus (house mouse) ]

Gene ID: 18127, updated on 24-May-2016
Official Symbol
Nos3provided by MGI
Official Full Name
nitric oxide synthase 3, endothelial cellprovided by MGI
Primary source
MGI:MGI:97362
See related
Ensembl:ENSMUSG00000028978 Vega:OTTMUSG00000024082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
eNOS; Nos-3; ecNOS; 2310065A03Rik
Orthologs
Location:
5 A3; 5 11.32 cM
Exon count:
26
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (24364819..24384474)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (23870637..23890292)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33476 Neighboring gene predicted gene 15589 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 2 Neighboring gene autophagy related 9B Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 8 Neighboring gene cyclin-dependent kinase 5 Neighboring gene acid-sensing (proton-gated) ion channel 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
FMN binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
actin monomer binding ISO
Inferred from Sequence Orthology
more info
 
arginine binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
tetrahydrobiopterin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
arginine catabolic process ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of muscle hyperplasia IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
nitric oxide mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
ovulation from ovarian follicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasodilation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of blood vessel size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of systemic arterial blood pressure by endothelin ISO
Inferred from Sequence Orthology
more info
 
regulation of the force of heart contraction by chemical signal IGI
Inferred from Genetic Interaction
more info
PubMed 
removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
smooth muscle hyperplasia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nitric oxide synthase, endothelial
Names
EC-NOS
NOS type III
NOSIII
cNOS
constitutive NOS
endothelial NOS
endothelial nitric oxide synthase
NP_032739.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008713.4NP_032739.3  nitric oxide synthase, endothelial

    See identical proteins and their annotated locations for NP_032739.3

    Status: VALIDATED

    Source sequence(s)
    AK077896, AW489695, U53142
    Consensus CDS
    CCDS19117.1
    UniProtKB/Swiss-Prot
    P70313
    UniProtKB/TrEMBL
    Q8C5P3
    Related
    ENSMUSP00000030834, OTTMUSP00000028591, ENSMUST00000030834, OTTMUST00000058885
    Conserved Domains (4) summary
    COG0369
    Location:5111158
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:67479
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:521697
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:7611163
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    24364819..24384474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535639.2XP_006535702.1  

    Conserved Domains (4) summary
    COG0369
    Location:4591106
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:15427
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:469645
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:7091111
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    21311457..21334226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)