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tth-1 Thymosin beta [ Caenorhabditis elegans ]

Gene ID: 181097, updated on 23-Nov-2023

Summary

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Gene symbol
tth-1
Gene description
Thymosin beta
Primary source
WormBase:WBGene00006649
Locus tag
CELE_F08F1.8
See related
AllianceGenome:WB:WBGene00006649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin monomer binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cell cortex; cell junction; and cytoskeleton. Predicted to be active in cytosol. Is expressed in gonad; intestine; nervous system; oocyte; and terminal bulb. Orthologous to human TMSB4X (thymosin beta 4 X-linked). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (8422480..8423731, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane 9 superfamily member Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats. Van Troys M, et al. Mol Biol Cell, 2004 Oct. PMID 15269284, Free PMC Article
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the activity of tetraThymosinbeta is of crucial importance at specific developmental stages requiring actin polymerization.
    Title: TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Thymosin beta
NP_509430.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8422480..8423731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077029.5 → NP_509430.1  Thymosin beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509430.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17389
    Conserved Domains (2) summary
    smart00152
    Location:51 → 87
    THY; Thymosin beta actin-binding motif
    pfam01290
    Location:22 → 47
    Thymosin; Thymosin beta-4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17389.2

Gene LinkOut

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