AGRP agouti related protein homolog (mouse) [Homo sapiens] - Gene

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Summary

Official Symbol: AGRPprovided by HGNC
Official Full Name: agouti related protein homolog (mouse)provided by HGNC
Primary source: HGNC:330
See related: Ensembl:ENSG00000159723; HPRD:09079; MIM:602311; Vega:OTTHUMG00000137509
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ART; AGRT; ASIP2; MGC118963
Summary: This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

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Genomic context

Location :: 16q22

Sequence :: Chromosome: 16; NC_000016.9 (67516474..67517716, complement)

See AGRP in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cognitive flexibility plays an important role in anorexia nervosa and may be modulated by abnormal levels of the appetite-regulating peptide AGRP.
Title: Cognitive flexibility and Agouti-related protein in adolescent patients with anorexia nervosa.
This review defines how peripheral signals (particularly leptin, insulin and glucose) converge on a molecular level in proopiomelanocortin (POMC)- and agouti-related protein (AgRP)-expressing arcuate nucleus neurons to control energy homeostasis.
Title: Hormone and glucose signalling in POMC and AgRP neurons.
Only the patients with nonalcoholic fatty liver presented a positive correlation between the saturated fatty acids intake and the orexigenic neuropeptides NPY and agouti related protein, and carbohydrate with NPY
Title: The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents.
AgRP may provide an important signal in the immune environment and the lymphocyte may be considered as an extra-hypothalamic source of plasma AgRP following exercise stress
Title: Acute circuit-resistance exercise increases expression of lymphocyte agouti-related protein in young women.
Agouti-related protein is neatively correlated with nonalcolic fatty liver disease in obese adolescents.
Title: Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy.
This study presents an association of rare allele of AGRP polymorphism in heterozygous state with increased body mass index
Title: Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI.
two adjacent enhancers inside the first intron of the neighboring (1.4 kb downstream) ATPase gene (ATP6V0D1) modulate the human AgRP promoter with profound spatiotemporal variation
Title: Control elements in the neighboring ATPase gene influence spatiotemporal expression of the human agouti-related protein.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of 182 candidate genes in anorexia nervosa.
Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans
Title: Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.

Submit: New GeneRIF Correction See all (23)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Products	Interactant	Other Gene	Source	Pubs	Description
O00253	Q9UBU3	GHRL	HPRD	PubMed
O00253	P41968	MC3R	HPRD	PubMed
O00253	P32245	MC4R	HPRD	PubMed
O00253	P33032	MC5R	HPRD	PubMed
BioGRID:106688	BioGRID:110330	MC4R	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
adult feeding behavior	IEA Inferred from Electronic Annotation more info
feeding behavior	TAS Traceable Author Statement more info	PubMed
hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
Golgi lumen	IDA Inferred from Direct Assay more info	PubMed
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: agouti-related protein

Names: agouti-related protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011501.1 RefSeqGene

Range

5001..6243

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001138.1 → NP_001129.1 agouti-related protein precursor

Status: REVIEWED

Source sequence(s)

U88063

Consensus CDS

CCDS10839.1

UniProtKB/TrEMBL

C6SUN5

UniProtKB/Swiss-Prot

O00253

Related

ENSP00000290953, OTTHUMP00000174803, ENST00000290953, OTTHUMT00000268828

Conserved Domains (1) summary

cl04902
Location:18 – 122
Blast Score: 233

Agouti; Agouti protein

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

67516474..67517716, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

53389602..53390844, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009061.10 (178974..180216)	None
genomic	AF281309.1	AAK96256.1
genomic	AF314194.1	AAL09457.1
genomic	BK006637.1	DAA06531.1
genomic	CH471092.1	EAW83137.1
genomic	DQ374394.1	ABC88473.1
mRNA	BC110443.2	AAI10444.1
mRNA	U88063.1	AAB52240.1
mRNA	U89485.1	AAB68621.1