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pfn-2 Profilin-2 [ Caenorhabditis elegans ]

Gene ID: 180808, updated on 11-Apr-2024

Summary

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Gene symbol
pfn-2
Gene description
Profilin-2
Primary source
WormBase:WBGene00003990
Locus tag
CELE_F35C8.6
See related
AllianceGenome:WB:WBGene00003990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin monomer binding activity. Involved in muscle thin filament assembly. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in cell cortex. Is expressed in intestine; neurons; pharynx; and spermatheca. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (5353103..5354072, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene BPH_2 domain-containing protein;PH domain-containing protein Neighboring gene Putative syntaxin-3 Neighboring gene Choline transporter-like protein 1 Neighboring gene ncRNA Neighboring gene Cholesterol 25-hydroxylase-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner. Polet D, et al. Cell Motil Cytoskeleton, 2006 Jan. PMID 16317718, Free PMC Article
  2. Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans. Yamashiro S, et al. J Cell Sci, 2008 Dec 1. PMID 18984629, Free PMC Article
  3. C. elegans longevity pathways converge to decrease mitochondrial membrane potential. Lemire BD, et al. Mech Ageing Dev, 2009 Jul. PMID 19442682
  4. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in muscle thin filament assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Profilin-2
NP_508910.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5353103..5354072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076509.7 → NP_508910.3  Profilin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508910.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20025, Q5GHR1
    Conserved Domains (1) summary
    smart00392
    Location:2 → 131
    PROF; Profilin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20025.3

Gene LinkOut

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