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Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [ Mus musculus (house mouse) ]

Gene ID: 18035, updated on 8-May-2016
Official Symbol
Nfkbiaprovided by MGI
Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alphaprovided by MGI
Primary source
MGI:MGI:104741
See related
Ensembl:ENSMUSG00000021025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nfkbi; AI462015
Orthologs
Location:
12; 12 C1-C3
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (55489409..55492647, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (56590396..56593634, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene Neighboring gene predicted gene, 36571 Neighboring gene predicted gene, 36634 Neighboring gene aldolase 1 A, retrogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to biotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasmic sequestering of NF-kappaB ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic sequestering of transcription factor ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus, translocation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle stretch IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NF-kappa-B inhibitor alpha
Names
I(Kappa)B(alpha)
I-kappa-B-alpha
I-kappaBalpha
ikB-alpha
ikappaBalpha
nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
nuclear factor of kappa light polyp gene enhancer in B-cell 1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010907.2NP_035037.2  NF-kappa-B inhibitor alpha

    See identical proteins and their annotated locations for NP_035037.2

    Status: VALIDATED

    Source sequence(s)
    AC158398, AI462015, BC046754, CF379853
    Consensus CDS
    CCDS25918.1
    UniProtKB/Swiss-Prot
    Q9Z1E3
    Related
    ENSMUSP00000021413, ENSMUST00000021413
    Conserved Domains (2) summary
    cd00204
    Location:105237
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:115246
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    55489409..55492647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    56639004..56642123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)