Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [ Mus musculus ]

Gene ID: 18033, updated on 19-May-2012

Help top of page

Summary

Official Symbol: Nfkb1provided by MGI
Official Full Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105provided by MGI
Primary source: MGI:97312
See related: Ensembl:ENSMUSG00000028163; Vega:OTTMUSG00000016668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1

Help top of page

Genomic context

Location :: 3 G3; 3 68.9 cM

Sequence :: Chromosome: 3; NC_000069.6 (135584655..135691547, complement)

See Nfkb1 in Epigenomics, MapViewer

Chromosome 3 - NC_000069.6 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-4 may protect mice against BCG/LPS-induced immune liver injury, with ERK and NF-kappaB signal pathways involved in the effects
Title: Protective effects of IL-4 on Bacillus Calmette-Guerin and lipopolysaccharide induced immunological liver injury in mice.
Supershift analysis showed that NF-kappaB DNA binding complex contains p52 and p65 in GM/DCs.
Title: Differential role of NF-κB, ERK1/2 and AP-1 in modulating the immunoregulatory functions of bone marrow-derived dendritic cells from NOD mice.
Our results identify RelA as an adaptor with which the E3 ligase SCF fine tunes NF-kappaB target genes by targeting the coactivator RIP140
Title: NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance.
Activation of TLR9 by BL-7040 leads to non-canonical activation of NF-kappaB.
Title: Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.
depletion of 14-3-3 protein induces cardiac oxidative stress, inflammation and remodeling after experimental diabetes induction mediated through p38 MAPK, MAPKAPK-2 and NF-kappaB signaling
Title: Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-ĸB signaling pathways after streptozotocin-induced diabetes mellitus.
computational analysis predicts the existence of cooperating elements on RelA-NF-kappaB/p300-enriched genes that could explain preferential binding and modulation of gene expression during mammary gland involution
Title: NF-ĸB as node for signal amplification during weaning.
alpha-terpineol, ameliorate bacterial vaginosis by inhibiting the growths of vaginal pathogens and the activation of NF- kappaB.
Title: Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-κB activation.
Gallic acid treatment efficiently blocked neuronal cell death by downregulating the expression of cytokines and the in vivo levels of NF-kappaB acetylation.
Title: Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation.
EGFR plays a critical role in mediating nontypeable Haemophilus influenzae -induced NF-kappaB activation and inflammation.
Title: Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.
Expressional inhibitions of iNOS, TNF-alpha, and IL-6 caused by an attenuation of NF-kappaB activation are responsible for the anti-inflammatory and antinociceptive activity of indoles.
Title: Indole-containing fractions of Brassica rapa inhibit inducible nitric oxide synthase and pro-inflammatory cytokine expression by inactivating nuclear factor-κB.

Submit: New GeneRIF Correction See all (611)

Help top of page

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation
Gene trapped (1) 1 citation
Targeted (knock-in) (1) 1 citation

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_032715.1	AF128879.1	Enpp2	BIND	PubMed	NF-kappaB binds to autotaxin promoter.
NP_032715.1	NC_000072.1	Igk-V28	BIND	PubMed	Nfkb1 (p50) interacts with Ig-kappa intronic enhancer within the Igk-V28 locus.
NP_032715.1	NT_039300.3	Il6	BIND	PubMed	p50 interacts with Il6(kappa-B).
NP_032715.1	NP_085115.1	Nfkbiz	BIND	PubMed	p50 interacts with I-kappa-B-zeta.
NP_032715.1	L09126.1	Nos2	BIND	PubMed	NF-kappaB binds to iNOS promoter.
NP_032715.1	NC_000068.1	Rag1	BIND	PubMed	Nfkb1 (p50) interacts with Rag1 intronic region.
NP_032715.1	NC_000068.1	Rag2	BIND	PubMed	Nfkb1 (p50) interacts with the Rag2 locus.
NP_032715.1	NP_033071.1	Rela	BIND	PubMed	p50 interacts with p65.
NP_032715.1	NT_039185.3	Sele	BIND	PubMed	p50 interacts with Elam1 promoter.
NP_032715.1			BIND	PubMed	The Stat6 homodimer interacts with NF-kappa-B p50.
BioGRID:201751	BioGRID:108201	E2F1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201751	BioGRID:230807	Gmeb2	BioGRID	PubMed	Two-hybrid
BioGRID:201751	BioGRID:241423	Hdac1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201751	BioGRID:200263	Hdac6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201751	BioGRID:201752	Nfkb2	BioGRID	PubMed	Two-hybrid
BioGRID:201751	BioGRID:201753	Nfkbia	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201751	BioGRID:219820	Nfkbiz	BioGRID	PubMed	Two-hybrid
BioGRID:201751	BioGRID:201429	Pias2	BioGRID	PubMed	Two-hybrid
BioGRID:201751	BioGRID:111898	REL	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:201751	BioGRID:202854	Relb	BioGRID	PubMed	Two-hybrid
BioGRID:201751	BioGRID:208217	Zfp276	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
heat shock protein binding	ISO Inferred from Sequence Orthology more info
nucleic acid binding transcription factor activity	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
anti-apoptosis	ISO Inferred from Sequence Orthology more info
apoptotic process	IEA Inferred from Electronic Annotation more info
lymph node development	TAS Traceable Author Statement more info	PubMed
negative regulation of calcidiol 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interleukin-12 biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of canonical Wnt receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
response to oxidative stress	ISO Inferred from Sequence Orthology more info
signal transduction	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	ISO Inferred from Sequence Orthology more info
mitochondrion	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: nuclear factor NF-kappa-B p105 subunit

Names: nuclear factor NF-kappa-B p105 subunit; EBP-1; NF kappaB1; NF-kappaB p50; DNA-binding factor KBF1; p50 subunit of NF kappaB; p50 subunit of NF-kappaB; nuclear factor kappaB p50; nuclear factor-kappaB p50; NF-kappa-B1 p84/NF-kappa-B1 p98; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008689.2 → NP_032715.2 nuclear factor NF-kappa-B p105 subunit

Status: VALIDATED

Source sequence(s)

AB221614, AK159423, AW907469, BC050841

Consensus CDS

CCDS17858.1

UniProtKB/Swiss-Prot

P25799

Related

ENSMUSP00000029812, OTTMUSP00000018024, ENSMUST00000029812, OTTMUST00000040338

Conserved Domains (5) summary

cd01177
Location:248 – 349
Blast Score: 469

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd00204
Location:572 – 701
Blast Score: 251

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd07935
Location:40 – 241
Blast Score: 1102

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

cd08797
Location:812 – 886
Blast Score: 359

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

pfam12796
Location:651 – 745
Blast Score: 188

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000069.6 Reference GRCm38 C57BL/6J

Range

135584655..135691547, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000025.1 Alternate Mm_Celera

Range

142004849..142111759, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC101973.7 (17770..35044)	None
genomic	AC110164.26 (109867..199234)	None
genomic	CH466532.2	EDL12139.1	mixed
		EDL12140.1	mixed
		EDL12141.1	mixed
		EDL12142.1	mixed
		EDL12143.1	mixed
mRNA	AB119195.1	BAC84979.1	C57BL/6CrSlc
mRNA	AB221614.1	None
mRNA	AK036827.1	None	C57BL/6J
mRNA	AK048506.1	None	C57BL/6J
mRNA	AK052726.1	BAC35117.1	C57BL/6J
mRNA	AK089660.1	BAE43399.1	NOD
mRNA	AK146389.1	None	BALB/c
mRNA	AK157915.1	BAE34261.1	C57BL/6J
mRNA	AK158020.1	None	C57BL/6J
mRNA	AK159423.1	None	C57BL/6J
mRNA	AW907469.1	None
mRNA	AY423849.1	AAR00341.1	C57BL
mRNA	AY521462.1	AAS00547.1	C3H/HeJBir
mRNA	AY521463.1	AAS00548.1	C57BL/6J
mRNA	BC050841.1	AAH50841.1
mRNA	BC138535.1	AAI38536.1
mRNA	BC138536.1	AAI38537.1
mRNA	BC145317.1	None
mRNA	L13466.1	AAC37644.1	BALB/cByJ
mRNA	L28117.1	None
mRNA	L28118.1	None
mRNA	M57999.1	AAA40415.1
mRNA	S66656.1	AAB28573.1
mRNA	S89033.1	AAB21851.1