DPP4 dipeptidyl-peptidase 4 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: DPP4provided by HGNC
Official Full Name: dipeptidyl-peptidase 4provided by HGNC
Primary source: HGNC:3009
See related: Ensembl:ENSG00000197635; HPRD:02187; MIM:102720; Vega:OTTHUMG00000132056
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD26; ADABP; ADCP2; DPPIV; TP103
Summary: The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 2q24.3

Sequence :: Chromosome: 2; NC_000002.11 (162848755..162931052, complement)

See DPP4 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that CD24 and CD26 differentially regulate the cancer stem cell potentials of malignant mesothelioma.
Title: Characterization of cancer stem cell properties of CD24 and CD26-positive human malignant mesothelioma cells.
Hepatic DPP4 mRNA expression was significantly greater in non-alcoholic fatty liver disease patients than in control subjects.
Title: Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism.
Higher serum DPP-4 activity and decreased CD26 lymphocyte expression on all lymphocyte subpopulations in T1DM.
Title: Higher serum DPP-4 enzyme activity and decreased lymphocyte CD26 expression in type 1 diabetes.
DPPIV plays a significant role in modulating the actions of neuropeptide Y (NPY) in arterioles of young adult females; however, this role appears to diminish with age.
Title: Neuropeptide Y overflow and metabolism in skeletal muscle arterioles.
Loss of DPP4 activity affects the anti-thrombogenic nature of the endothelium.
Title: Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients.
DPP4 is increased in papillary thyroid cancer, however, its diagnostic usefulness as a single PTC marker is doubtfu
Title: [Expression of DPP4 gene in papillary thyroid carcinoma].
CD26 expression may be associated in the regulation of DPP-IV in type 2 diabetes patients
Title: Expression of CD26 and its association with dipeptidyl peptidase IV activity in lymphocytes of type 2 diabetes patients.
A higher serum level of sCD26 is associated with a worse response to sitagliptin in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea therapy.
Title: Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea.
Overexpression and localization of CD26 in mesothelioma tissue and mesothelioma cell lines
Title: Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines.
residues important for dimer formation and enzymatic activity
Title: Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9.

Submit: New GeneRIF Correction See all (154)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	SDF-1alpha and HIV-1 gp120 induce the appearance of pseudopodia in which CD26 and CXCR4 co-localize	PubMed
	env	Infection of cells with Macrophage-tropic HIV-1 confers preferential survival to cells with low CD26 levels; the third hypervariable region (V3) of the HIV-1 gp120 envelope protein plays an important role in this selection process	PubMed
	env	Although CD26 has been described as a cofactor for HIV-1 gp120 mediated entry into cells, no evidence of a CD26-gp120 interaction was observed in vitro by using glutathione S-transferase-tagged HIV-1 gp120	PubMed
	env	Apoptosis is observed in CD4+ cells expressing the HIV-1 gp120/gp41 complex and with enhanced levels of CD26, but is not detected in cell lines expressing an uncleavable precursor of HIV-1 gp160	PubMed
	env	CD26 (dipeptidyl peptidase IV) cleaves the highly conserved V3 loop of HIV-1 gp120 and functions as a cofactor for entry of HIV-1 in CD4+ human cells; coexpression of human CD4 and CD26 in murine NIH 3T3 cells renders them permissive to HIV-1	PubMed
	env	HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4	PubMed
	env	Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC	PubMed
Envelope transmembrane glycoprotein gp41	env	Apoptosis is observed in CD4+ cells expressing the HIV-1 gp120/gp41 complex and with enhanced levels of CD26, but is not detected in cell lines expressing an uncleavable precursor of HIV-1 gp160	PubMed
Tat	tat	HIV-1 Tat inhibits the enzymatic activity of CD26, thereby suppressing DNA synthesis and IL-1 beta production, stimulating secretion of IL-1 receptor antagonist and TNF-alpha, and causing, at least in part, the immunosuppressive effects of Tat	PubMed
	tat	The N-terminal nine amino acids of HIV-1 Tat mediate the binding of Tat to CD26	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
P27487	P00813	ADA	HPRD	PubMed
P27487	P51671	CCL11	HPRD	PubMed
P27487	O00626	CCL22	HPRD	PubMed
P27487	P16619	CCL3L1	HPRD	PubMed
P27487	P13501	CCL5	HPRD	PubMed
P27487	P01730	CD4	HPRD	PubMed
P27487	Alpha 2 macroglobulin family protein VIP	CPAMD8	HPRD	PubMed
P27487	P02778	CXCL10	HPRD	PubMed
P27487	O14625	CXCL11	HPRD	PubMed
P27487	P48061	CXCL12	HPRD	PubMed
P27487	Q07325	CXCL9	HPRD	PubMed
P27487	P61073	CXCR4	HPRD	PubMed
P27487	P27487	DPP4	HPRD	PubMed
P27487	Q12884	FAP	HPRD	PubMed
P27487	P07492	GRP	HPRD	PubMed
P27487	P08575	PTPRC	HPRD	PubMed
BioGRID:108137	BioGRID:112270	CCL22	BioGRID	PubMed	Biochemical Activity

Function	Evidence Code	Pubs
aminopeptidase activity	IEA Inferred from Electronic Annotation more info
collagen binding	IEA Inferred from Electronic Annotation more info
dipeptidyl-peptidase activity	IDA Inferred from Direct Assay more info	PubMed
peptidase activity	IEA Inferred from Electronic Annotation more info
peptide binding	IEA Inferred from Electronic Annotation more info
protease binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
receptor binding	IPI Inferred from Physical Interaction more info	PubMed
serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
T cell activation	IDA Inferred from Direct Assay more info	PubMed
T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
cell adhesion	IEA Inferred from Electronic Annotation more info
endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
establishment of localization	IEA Inferred from Electronic Annotation more info
negative regulation of extracellular matrix disassembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
proteolysis	IEA Inferred from Electronic Annotation more info
regulation of T cell mediated immunity	IEA Inferred from Electronic Annotation more info
regulation of cell-cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cell junction	IEA Inferred from Electronic Annotation more info
cell surface	IDA Inferred from Direct Assay more info	PubMed
endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
intercellular canaliculus	IEA Inferred from Electronic Annotation more info
invadopodium membrane	IDA Inferred from Direct Assay more info	PubMed
lamellipodium	IDA Inferred from Direct Assay more info	PubMed
lamellipodium membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IEA Inferred from Electronic Annotation more info
membrane raft	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
soluble fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: dipeptidyl peptidase 4

Names: dipeptidyl peptidase 4; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)

NP_001926.2

EC 3.4.14.5

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001935.3 → NP_001926.2 dipeptidyl peptidase 4

Status: REVIEWED

Source sequence(s)

BC065265

Consensus CDS

CCDS2216.1

UniProtKB/Swiss-Prot

P27487

Related

ENSP00000353731, OTTHUMP00000162936, ENST00000360534, OTTHUMT00000255079

Conserved Domains (2) summary

pfam00930
Location:108 – 478
Blast Score: 986

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl12031
Location:559 – 763
Blast Score: 551

Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

162848755..162931052, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

154730637..154813409, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC008063.2	AAX93179.1
genomic	CH471058.2	EAX11361.1
		EAX11362.1
genomic	CQ772397.1	CAF33874.1
genomic	HI179156.1	CBX53886.1
genomic	S79876.1	AAB35614.1
genomic	U13710.1	AAB60646.1
genomic	U13711.1	AAB60646.1
genomic	U13712.1	AAB60646.1
genomic	U13713.1	AAB60646.1
genomic	U13714.1	AAB60646.1
genomic	U13715.1	AAB60646.1
genomic	U13716.1	AAB60646.1
genomic	U13717.1	AAB60646.1
genomic	U13718.1	AAB60646.1
genomic	U13719.1	AAB60646.1
genomic	U13720.1	AAB60646.1
genomic	U13721.1	AAB60646.1
genomic	U13722.1	AAB60646.1
genomic	U13723.1	AAB60646.1
genomic	U13724.1	AAB60646.1
genomic	U13725.1	AAB60646.1
genomic	U13726.1	AAB60646.1
genomic	U13727.1	AAB60646.1
genomic	U13728.1	AAB60646.1
genomic	U13729.1	AAB60646.1
genomic	U13730.1	AAB60646.1
genomic	U13731.1	AAB60646.1
genomic	U13732.1	AAB60646.1
genomic	U13733.1	AAB60646.1
genomic	U13734.1	AAB60646.1
genomic	U13735.1	AAB60646.1
mRNA	AB451339.1	BAG70153.1
mRNA	AB451488.1	BAG70302.1
mRNA	AK314798.1	None
mRNA	AY429531.1	None
mRNA	AY429532.1	None
mRNA	AY429533.1	None
mRNA	BC013329.2	AAH13329.2
mRNA	BC065265.1	AAH65265.1
mRNA	M74777.1	AAA51943.1
mRNA	M80536.1	AAA52308.1
mRNA	X60708.1	CAA43118.1