Format

Send to:

Choose Destination

Nfia nuclear factor I/A [ Mus musculus (house mouse) ]

Gene ID: 18027, updated on 21-May-2016
Official Symbol
Nfiaprovided by MGI
Official Full Name
nuclear factor I/Aprovided by MGI
Primary source
MGI:MGI:108056
See related
Ensembl:ENSMUSG00000028565 Vega:OTTMUSG00000007951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTF; NF1A; NF1-A; 1110047K16Rik; 9430022M17Rik
Orthologs
Location:
4 45.52 cM; 4 C4-C6
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (97581717..98118876)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (97248634..97785567)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130114P18 gene Neighboring gene predicted gene 12696 Neighboring gene U2 small nuclear ribonucleoprotein B pseudogene Neighboring gene predicted gene, 40209 Neighboring gene uncharacterized LOC102637577 Neighboring gene predicted gene, 38709 Neighboring gene uncharacterized LOC102637515 Neighboring gene predicted gene, 40208 Neighboring gene predicted gene, 34218 Neighboring gene predicted gene, 34784 Neighboring gene predicted gene 12691 Neighboring gene ras homolog gene family, member G pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nuclear factor 1 A-type
Names
CCAAT-box-binding transcription factor
TGGCA-binding protein
nuclear factor 1/A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122952.1NP_001116424.1  nuclear factor 1 A-type isoform 1

    See identical proteins and their annotated locations for NP_001116424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK052204, AK139357, AL670260, AW122288
    UniProtKB/Swiss-Prot
    Q02780
    UniProtKB/TrEMBL
    Q3UTK6
    Conserved Domains (3) summary
    pfam00859
    Location:237532
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:3369
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91195
    MH1; N-terminal Mad Homology 1 (MH1) domain
  2. NM_001122953.1NP_001116425.1  nuclear factor 1 A-type isoform 3

    See identical proteins and their annotated locations for NP_001116425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon and lacks an internal coding exon, which does not affect the reading frame, as compared to variant 1. The resulting isoform (2) has a different and shorter N-terminus and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AL670195, AL670260, AL671238, AW122288, BC122878, BC122880
    Consensus CDS
    CCDS51234.1
    UniProtKB/Swiss-Prot
    Q02780
    UniProtKB/TrEMBL
    Q05B39
    Related
    ENSMUSP00000130032, ENSMUST00000092532
    Conserved Domains (3) summary
    pfam00859
    Location:214466
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:346
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68172
    MH1; N-terminal Mad Homology 1 (MH1) domain
  3. NM_010905.3NP_035035.1  nuclear factor 1 A-type isoform 2

    See identical proteins and their annotated locations for NP_035035.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a different and shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AF326553, AL670195, AL670260, AL671238, AW122288
    Consensus CDS
    CCDS18373.1
    UniProtKB/Swiss-Prot
    Q02780
    Related
    ENSMUSP00000074899, OTTMUSP00000008283, ENSMUST00000075448, OTTMUST00000018038
    Conserved Domains (3) summary
    pfam00859
    Location:214509
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:346
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68172
    MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    97581717..98118876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502844.2XP_006502907.1  

    Conserved Domains (3) summary
    pfam00859
    Location:237489
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:3369
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91195
    MH1; N-terminal Mad Homology 1 (MH1) domain
  2. XM_006502841.2XP_006502904.1  

    Conserved Domains (3) summary
    pfam00859
    Location:237496
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:3369
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91195
    MH1; N-terminal Mad Homology 1 (MH1) domain
  3. XM_006502842.2XP_006502905.1  

    See identical proteins and their annotated locations for XP_006502905.1

    UniProtKB/Swiss-Prot
    Q02780
    Conserved Domains (3) summary
    pfam00859
    Location:206501
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:238
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60164
    MH1; N-terminal Mad Homology 1 (MH1) domain
  4. XM_006502843.2XP_006502906.1  

    UniProtKB/TrEMBL
    B1AUC0
    Related
    ENSMUSP00000102677, OTTMUSP00000008285, ENSMUST00000107062, OTTMUST00000018040
    Conserved Domains (3) summary
    pfam00859
    Location:214473
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:346
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68172
    MH1; N-terminal Mad Homology 1 (MH1) domain
  5. XM_006502845.2XP_006502908.1  

    See identical proteins and their annotated locations for XP_006502908.1

    UniProtKB/TrEMBL
    Q05B39
    Conserved Domains (3) summary
    pfam00859
    Location:214430
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:346
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68172
    MH1; N-terminal Mad Homology 1 (MH1) domain

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    95943228..96479959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)