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Neurod1 neurogenic differentiation 1 [ Mus musculus (house mouse) ]

Gene ID: 18012, updated on 28-May-2016
Official Symbol
Neurod1provided by MGI
Official Full Name
neurogenic differentiation 1provided by MGI
Primary source
MGI:MGI:1339708
See related
Ensembl:ENSMUSG00000034701 Vega:OTTMUSG00000013310
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BETA2; BHF-1; Neurod; bHLHa3
Orthologs
Location:
2 C3; 2 47.58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (79452641..79456636, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (79292798..79296793, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39866 Neighboring gene integrin alpha 4 Neighboring gene ceramide kinase-like Neighboring gene tubulin, beta 6 pseudogene Neighboring gene predicted gene, 39867 Neighboring gene sperm specific antigen 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
E-box binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
amacrine cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dentate gyrus development IGI
Inferred from Genetic Interaction
more info
PubMed 
dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
enteroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin secretion ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron development IEA
Inferred from Electronic Annotation
more info
 
nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
pancreatic A cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
pancreatic PP cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intestinal epithelial structure maintenance IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to glucose ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
neurogenic differentiation factor 1
Names
beta-cell E-box transcriptional activator 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010894.2NP_035024.1  neurogenic differentiation factor 1

    See identical proteins and their annotated locations for NP_035024.1

    Status: PROVISIONAL

    Source sequence(s)
    AK005073
    Consensus CDS
    CCDS16169.1
    UniProtKB/Swiss-Prot
    Q60867
    Related
    ENSMUSP00000040364, OTTMUSP00000014302, ENSMUST00000041099, OTTMUST00000032176
    Conserved Domains (2) summary
    cd00083
    Location:100158
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam12533
    Location:160284
    Neuro_bHLH; Neuronal helix-loop-helix transcription factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    79452641..79456636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    81111974..81115969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)