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    Neurl1a neuralized homolog 1A (Drosophila) [ Mus musculus ]

    Gene ID: 18011, updated on 11-May-2012

    Summary

    Official Symbol
    Neurl1aprovided by MGI
    Official Full Name
    neuralized homolog 1A (Drosophila)provided by MGI
    Primary source
    MGI:1334263
    See related
    Ensembl:ENSMUSG00000006435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nlz; Neu1; Neur1; Neurl; Rnf67; AI450910; AI481072; 2410129E16Rik

    Genomic context

    Location :
    19 C3; 19 49.25 cM
    Sequence :
    Chromosome: 19; NC_000085.6 (47178820..47259441)
    See Neurl1a in Epigenomics, MapViewer

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene calcium homeostasis modulator 3 Neighboring gene histone cluster 1, H1b pseudogene Neighboring gene SH3 and PX domains 2A Neighboring gene oligonucleotide/oligosaccharide-binding fold containing 1 Neighboring gene predicted gene, 19557

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:201732 BioGRID:229024 Cpeb3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:201732 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to external stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    NOT nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neuralized-like protein 1A
    Names
    neuralized-like protein 1A
    m-neu1
    m-neuralized 1
    neuralized-like homolog
    neuralized-like protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163480.1NP_001156952.1  neuralized-like protein 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC132288, BC058386, BC099702
      Consensus CDS
      CCDS50463.1
      UniProtKB/TrEMBL
      Q499W5
      UniProtKB/Swiss-Prot
      Q923S6
      Related
      ENSMUSP00000107438, ENSMUST00000111807
      Conserved Domains (3) summary
      cd00162
      Location:503547
      Blast Score: 99
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02685
      Location:44166
      Blast Score: 437
      Neuralized; Neuralized
      pfam13923
      Location:501545
      Blast Score: 107
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
    2. NM_021360.4NP_067335.4  neuralized-like protein 1A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC058386, BC099702
      Consensus CDS
      CCDS29890.1
      UniProtKB/TrEMBL
      Q499W5
      UniProtKB/Swiss-Prot
      Q923S6
      Related
      ENSMUSP00000107439, ENSMUST00000111808
      Conserved Domains (3) summary
      cd00162
      Location:520564
      Blast Score: 100
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02685
      Location:61183
      Blast Score: 436
      Neuralized; Neuralized
      pfam13923
      Location:518562
      Blast Score: 108
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38 C57BL/6J

      Range
      47178820..47259441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000041.1 Alternate Mm_Celera

      Range
      47936911..48016141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AC132288.5 (50825..131446) None
    genomic AJ271919.1 CAC88133.1 129/SvJ
    genomic AJ271920.1 None 129/SvJ
    genomic AJ271921.1 None 129/SvJ
    genomic AJ271922.1 None 129/SvJ
    genomic AJ271923.1 None 129/SvJ
    genomic CH466534.1 EDL42031.1 mixed
      EDL42032.1 mixed
    mRNA AF400063.1 AAK84420.1 C57BL/6
    mRNA AF401228.1 AAK97495.1
    mRNA AK010787.1 BAB27183.1 C57BL/6J
    mRNA AK032915.1 None C57BL/6J
    mRNA AK046382.1 None C57BL/6J
    mRNA AK078529.1 None C57BL/6J
    mRNA BC058386.1 AAH58386.1 C57BL/6
    mRNA BC099702.1 AAH99702.1 C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499W5 GenPept UniProtKB/TrEMBL:Q499W5
    Q923S6.1 GenPept UniProtKB/Swiss-Prot:Q923S6

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