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nhr-50 Nuclear receptor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180067, updated on 11-Apr-2024

Summary

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Gene symbol
nhr-50
Gene description
Nuclear receptor domain-containing protein
Primary source
WormBase:WBGene00003640
Locus tag
CELE_C06C6.5
See related
AllianceGenome:WB:WBGene00003640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in intestine; nervous system; pharynx; rectal gland cell; and tail. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (15997726..16000631, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene protein of unknown function WSN domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Miyabayashi T, et al. Dev Biol, 1999 Nov 15. PMID 10545240
  2. The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Etchberger JF, et al. Genes Dev, 2007 Jul 1. PMID 17606643, Free PMC Article
  3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear receptor domain-containing protein
NP_507015.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15997726..16000631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074614.8 → NP_507015.3  Nuclear receptor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507015.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62031
    Conserved Domains (2) summary
    smart00399
    Location:3 → 68
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:156 → 327
    HOLI; Ligand binding domain of hormone receptors

RNA

  1. NR_136354.1 RNA Sequence

    Status: REVIEWED

  2. NR_136353.1 RNA Sequence

    Status: REVIEWED

  3. NR_136352.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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