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mdt-28 Coiled-coil domain-containing protein mdt-28 [ Caenorhabditis elegans ]

Gene ID: 180048, updated on 20-Oct-2023

Summary

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Gene symbol
mdt-28
Gene description
Coiled-coil domain-containing protein mdt-28
Primary source
WormBase:WBGene00009223
Locus tag
CELE_F28F8.5
See related
AllianceGenome:WB:WBGene00009223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including gonad; hypodermis; and intestine. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (15574098..15575405, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Ataxin-3 homolog Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Valproic Acid Decreases the Nuclear Localization of MDT-28, the Nematode Orthologue of MED28. Kostrouchová M, et al. Folia Biol (Praha), 2018. PMID 29871732
  2. The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development. Kostrouchová M, et al. PeerJ, 2017. PMID 28603670, Free PMC Article
  3. Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins. Yilma P, et al. Folia Biol (Praha), 2019. PMID 32362303
  4. MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans. Xie K, et al. Sci Rep, 2019 Oct 17. PMID 31624276, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans.
    Title: MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans.
  2. The results provide evidence for MDT-28 engagement in the Mediator Head module and support the possibility of physical (direct or indirect) interaction of MDT-28 with additional proteins.
    Title: Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Coiled-coil domain-containing protein mdt-28
NP_001256673.1
  • Confirmed by transcript evidence
NP_001380113.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15574098..15575405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269744.2 → NP_001256673.1  Coiled-coil domain-containing protein mdt-28 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256673.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9G301

  2. NM_001392672.1 → NP_001380113.1  Coiled-coil domain-containing protein mdt-28 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9G301, O18692
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H9G301.1

Gene LinkOut

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