bmk-1 Kinesin-like protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: bmk-1
Gene description: Kinesin-like protein
Primary source: WormBase:WBGene00000257
Locus tag: CELE_F23B12.8
See related: AllianceGenome:WB:WBGene00000257
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable plus-end-directed microtubule motor activity. Involved in negative regulation of mitotic spindle elongation. Located in spindle midzone and spindle pole. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (14453302..14456984, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The microtubule-bundling protein SPD-1/MAP-65 and BMK-1/kinesin-5 act as a brake opposing the force generated by the spindle midzone during Caenorhabditis elegans mitosis.
Title: Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner.
Kinesin-5 (Bmk-1)acts as rate-limiting brake for interpolar microtubule sliding.
Title: Kinesin-5 acts as a brake in anaphase spindle elongation.
deployed as a brake to slow down spindle-pole separation
Title: Mitotic motors: kinesin-5 takes a brake.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F23B12.8 (e-PCR)
- UniSTS:307530

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Kinesin-like protein

NP_001256586.1

Confirmed by transcript evidence

NP_001379525.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14453302..14456984 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392655.1 → NP_001379525.1 Kinesin-like protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5ECF4

Conserved Domains (2) summary

pfam15921
Location:365 → 839

CCDC158; Coiled-coil domain-containing protein 158

cl22853
Location:17 → 359

Motor_domain; Myosin and Kinesin motor domain
NM_001269657.2 → NP_001256586.1 Kinesin-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256586.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EGL7

Conserved Domains (2) summary

smart00129
Location:13 → 352

KISc; Kinesin motor, catalytic domain. ATPase

cl22853
Location:12 → 354

Motor_domain; Myosin and Kinesin motor domain