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Nck1 non-catalytic region of tyrosine kinase adaptor protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17973, updated on 21-May-2016
Official Symbol
Nck1provided by MGI
Official Full Name
non-catalytic region of tyrosine kinase adaptor protein 1provided by MGI
Primary source
MGI:MGI:109601
See related
Ensembl:ENSMUSG00000032475 Vega:OTTMUSG00000021049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nck; Nck-1; 6330586M15Rik; D230010O13Rik
Orthologs
Location:
9; 9 E3.3
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (100494981..100546053, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (100395422..100446472, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene 28166 Neighboring gene interleukin 20 receptor beta Neighboring gene solute carrier family 35, member G2 Neighboring gene stromal antigen 1 Neighboring gene predicted gene 8661

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
eukaryotic initiation factor eIF2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
eukaryotic initiation factor eIF2 binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell activation ISO
Inferred from Sequence Orthology
more info
 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of PERK-mediated unfolded protein response IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cap-dependent translational initiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cap-independent translational initiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of translation in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
response to other organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate-dependent cell migration, cell extension IGI
Inferred from Genetic Interaction
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
 
ribosome ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cytoplasmic protein NCK1
Names
NCK adaptor protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324530.1NP_001311459.1  cytoplasmic protein NCK1 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a distinct promoter and therefore has a distinct 5' UTR and 5' coding region, compared to variant 1. This variant encodes isoform 2 which, compared to isoform 1, lacks an N-terminal SH3 domain.
    Source sequence(s)
    AK053155, AK054051
  2. NM_010878.3NP_035008.2  cytoplasmic protein NCK1 isoform 1

    See identical proteins and their annotated locations for NP_035008.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK053155, BY096444, CJ171968
    Consensus CDS
    CCDS23440.1
    UniProtKB/Swiss-Prot
    Q99M51
    Related
    ENSMUSP00000112221, OTTMUSP00000023124, ENSMUST00000116522, OTTMUST00000049788
    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    100494981..100546053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510840.1XP_006510903.1  

    See identical proteins and their annotated locations for XP_006510903.1

    UniProtKB/Swiss-Prot
    Q99M51
    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
  2. XM_006510841.2XP_006510904.1  

    See identical proteins and their annotated locations for XP_006510904.1

    UniProtKB/TrEMBL
    Q8BH99
    Related
    ENSMUSP00000108495, OTTMUSP00000023125, ENSMUST00000112874, OTTMUST00000049789
    Conserved Domains (3) summary
    cd10408
    Location:216312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:4498
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    100033773..100084727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)