egl-10 Regulator of G-protein signaling egl-10 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: egl-10
Gene description: Regulator of G-protein signaling egl-10
Primary source: WormBase:WBGene00001179
Locus tag: CELE_F28C1.2
See related: AllianceGenome:WB:WBGene00001179
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including dopamine receptor signaling pathway; regulation of oviposition; and rhythmic behavior. Located in cytoplasm and neuron projection. Is expressed in body wall musculature and neurons. Orthologous to human RGS6 (regulator of G protein signaling 6) and RGS7 (regulator of G protein signaling 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (12453290..12463008, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the N-terminal region of EGL-10 directs inhibition of G(alpha) signaling by forming a complex with the GGL/RGS region and affecting its stability, membrane localization, and G(alpha) target specificity
Title: An N-terminal region of Caenorhabditis elegans RGS proteins EGL-10 and EAT-16 directs inhibition of G(alpha)o versus G(alpha)q signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F28C1.2 (e-PCR)
- UniSTS:307550

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Regulator of G-protein signaling egl-10

NP_001256418.1

Confirmed by transcript evidence

NP_001256419.1

Partially confirmed by transcript evidence

NP_001256420.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12453290..12463008 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269489.4 → NP_001256418.1 Regulator of G-protein signaling egl-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256418.1

Status: REVIEWED

UniProtKB/TrEMBL

F5GUD0

Conserved Domains (3) summary

smart00224
Location:334 → 395

GGL; G protein gamma subunit-like motifs

cd08705
Location:414 → 535

RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_001269491.2 → NP_001256420.1 Regulator of G-protein signaling egl-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256420.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P49809, Q19855

Conserved Domains (3) summary

smart00224
Location:334 → 395

GGL; G protein gamma subunit-like motifs

cd08705
Location:414 → 535

RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_001269490.3 → NP_001256419.1 Regulator of G-protein signaling egl-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256419.1

Status: REVIEWED

UniProtKB/TrEMBL

F5GUC9

Conserved Domains (3) summary

smart00224
Location:334 → 395

GGL; G protein gamma subunit-like motifs

cd08705
Location:414 → 535

RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...