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Ncf2 neutrophil cytosolic factor 2 [ Mus musculus (house mouse) ]

Gene ID: 17970, updated on 8-May-2016
Official Symbol
Ncf2provided by MGI
Official Full Name
neutrophil cytosolic factor 2provided by MGI
Primary source
MGI:MGI:97284
See related
Ensembl:ENSMUSG00000026480 Vega:OTTMUSG00000049696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NOXA2; Ncf-2; p67phox
Orthologs
Location:
1 G3; 1 65.05 cM
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (152800158..152837169)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (154655020..154684120)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator,-like 1 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) Neighboring gene actin related protein 2/3 complex, subunit 5 Neighboring gene Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) Neighboring gene predicted gene, 29954 Neighboring gene ribosomal protein S2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rac GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to superoxide-generating NADPH oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to superoxide-generating NADPH oxidase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
Process Evidence Code Pubs
NADP catabolic process ISA
Inferred from Sequence Alignment
more info
PubMed 
cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
response to glucose ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
superoxide metabolic process ISA
Inferred from Sequence Alignment
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISA
Inferred from Sequence Alignment
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
neutrophil cytosol factor 2
Names
67 kDa neutrophil oxidase factor
NADPH oxidase activator 2
NADPH oxidase subunit (67kDa)
neutrophil NADPH oxidase factor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010877.5NP_035007.1  neutrophil cytosol factor 2

    See identical proteins and their annotated locations for NP_035007.1

    Status: VALIDATED

    Source sequence(s)
    AK036379, BC076609, BY097838
    Consensus CDS
    CCDS15367.1
    UniProtKB/Swiss-Prot
    O70145
    Related
    ENSMUSP00000027754, ENSMUST00000027754
    Conserved Domains (6) summary
    cd06406
    Location:350428
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:460511
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    pfam00515
    Location:7199
    TPR_1; Tetratricopeptide repeat
    pfam13424
    Location:38102
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:632
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    152800158..152837169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529236.2XP_006529299.1  

    See identical proteins and their annotated locations for XP_006529299.1

    UniProtKB/Swiss-Prot
    O70145
    Conserved Domains (6) summary
    cd06406
    Location:350428
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:460511
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    pfam00515
    Location:7199
    TPR_1; Tetratricopeptide repeat
    pfam13424
    Location:38102
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:632
    TPR; TPR repeat [structural motif]
  2. XM_006529235.2XP_006529298.1  

    Related
    ENSMUSP00000140404, OTTMUSP00000068431, ENSMUST00000186568, OTTMUST00000126584
    Conserved Domains (6) summary
    cd06406
    Location:350428
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:460511
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    pfam00515
    Location:7199
    TPR_1; Tetratricopeptide repeat
    pfam13424
    Location:38102
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:632
    TPR; TPR repeat [structural motif]

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    155229233..155258077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)