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DXO decapping exoribonuclease [ Homo sapiens (human) ]

Gene ID: 1797, updated on 8-May-2016
Official Symbol
DXOprovided by HGNC
Official Full Name
decapping exoribonucleaseprovided by HGNC
Primary source
HGNC:HGNC:2992
See related
Ensembl:ENSG00000204348 HPRD:16186; MIM:605996; Vega:OTTHUMG00000031272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NG6; RAI1; DOM3L; DOM3Z
Summary
This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6p21.3
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (31969811..31972290, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31937588..31940032, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member E Neighboring gene microRNA 1236 Neighboring gene Ski2 like RNA helicase Neighboring gene serine/threonine kinase 19 Neighboring gene complement component 4A (Rodgers blood group) Neighboring gene cytochrome P450 family 21 subfamily A member 1, pseudogene Neighboring gene tenascin XA (pseudogene)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
NHGRI GWA Catalog
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-3' exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA pyrophosphohydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear mRNA surveillance ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleic acid phosphodiester bond hydrolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
decapping and exoribonuclease protein
Names
protein Dom3Z

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005510.3NP_005501.2  decapping and exoribonuclease protein

    See identical proteins and their annotated locations for NP_005501.2

    Status: REVIEWED

    Source sequence(s)
    AF059252, BC019083
    Consensus CDS
    CCDS4732.1
    UniProtKB/Swiss-Prot
    O77932
    UniProtKB/TrEMBL
    A0A024RCW8
    Related
    ENSP00000337759, OTTHUMP00000029408, ENST00000337523, OTTHUMT00000076590
    Conserved Domains (1) summary
    pfam08652
    Location:235302
    RAI1; RAI1 like PD-(D/E)XK nuclease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    31969811..31972290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715005.2XP_006715068.1  

    See identical proteins and their annotated locations for XP_006715068.1

    UniProtKB/Swiss-Prot
    O77932
    UniProtKB/TrEMBL
    A0A024RCW8
    Related
    ENSP00000364498, OTTHUMP00000029410, ENST00000375349, OTTHUMT00000076592
    Conserved Domains (1) summary
    pfam08652
    Location:235302
    RAI1; RAI1 like PD-(D/E)XK nuclease
  2. XM_006715007.2XP_006715070.1  

    See identical proteins and their annotated locations for XP_006715070.1

    Conserved Domains (1) summary
    pfam08652
    Location:51118
    RAI1; RAI1 like PD-(D/E)XK nuclease

RNA

  1. XR_926082.1 RNA Sequence

    Related
    ENST00000485557
  2. XR_926081.1 RNA Sequence

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    3447238..3449717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725474.2XP_006725537.1  

    See identical proteins and their annotated locations for XP_006725537.1

    UniProtKB/Swiss-Prot
    O77932
    UniProtKB/TrEMBL
    A0A024RCW8
    Conserved Domains (1) summary
    pfam08652
    Location:235302
    RAI1; RAI1 like PD-(D/E)XK nuclease
  2. XM_006725476.2XP_006725539.1  

    See identical proteins and their annotated locations for XP_006725539.1

    Conserved Domains (1) summary
    pfam08652
    Location:51118
    RAI1; RAI1 like PD-(D/E)XK nuclease

RNA

  1. XR_952208.1 RNA Sequence

  2. XR_952207.1 RNA Sequence

Reference GRCh38.p2 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p2 ALT_REF_LOCI_3

    Range
    3217586..3220065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725688.2XP_006725751.1  

    Conserved Domains (1) summary
    pfam08652
    Location:235302
    RAI1; RAI1 like PD-(D/E)XK nuclease
  2. XM_006725690.2XP_006725753.1  

    Conserved Domains (1) summary
    pfam08652
    Location:51118
    RAI1; RAI1 like PD-(D/E)XK nuclease
  3. XM_011547606.1XP_011545908.1  

    UniProtKB/TrEMBL
    F8WC68

Reference GRCh38.p2 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p2 ALT_REF_LOCI_5

    Range
    3311847..3314326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725898.2XP_006725961.1  

    See identical proteins and their annotated locations for XP_006725961.1

    UniProtKB/Swiss-Prot
    O77932
    UniProtKB/TrEMBL
    A0A024RCW8
    Conserved Domains (1) summary
    pfam08652
    Location:235302
    RAI1; RAI1 like PD-(D/E)XK nuclease
  2. XM_006725900.2XP_006725963.1  

    See identical proteins and their annotated locations for XP_006725963.1

    Conserved Domains (1) summary
    pfam08652
    Location:51118
    RAI1; RAI1 like PD-(D/E)XK nuclease

RNA

  1. XR_952942.1 RNA Sequence

  2. XR_952941.1 RNA Sequence

Reference GRCh38.p2 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p2 ALT_REF_LOCI_6

    Range
    3225781..3228260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725985.2XP_006726048.1  

    See identical proteins and their annotated locations for XP_006726048.1

    UniProtKB/Swiss-Prot
    O77932
    UniProtKB/TrEMBL
    A0A024RCW8
    Conserved Domains (1) summary
    pfam08652
    Location:235302
    RAI1; RAI1 like PD-(D/E)XK nuclease
  2. XM_006725987.2XP_006726050.1  

    See identical proteins and their annotated locations for XP_006726050.1

    Conserved Domains (1) summary
    pfam08652
    Location:51118
    RAI1; RAI1 like PD-(D/E)XK nuclease

RNA

  1. XR_953004.1 RNA Sequence

  2. XR_953003.1 RNA Sequence

Reference GRCh38.p2 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p2 ALT_REF_LOCI_7

    Range
    3271000..3273479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006726078.2XP_006726141.1  

    See identical proteins and their annotated locations for XP_006726141.1

    UniProtKB/Swiss-Prot
    O77932
    UniProtKB/TrEMBL
    A0A024RCW8
    Conserved Domains (1) summary
    pfam08652
    Location:235302
    RAI1; RAI1 like PD-(D/E)XK nuclease
  2. XM_006726080.2XP_006726143.1  

    See identical proteins and their annotated locations for XP_006726143.1

    Conserved Domains (1) summary
    pfam08652
    Location:51118
    RAI1; RAI1 like PD-(D/E)XK nuclease

RNA

  1. XR_953078.1 RNA Sequence

  2. XR_953077.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    31939669..31942113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)