Ncam1 neural cell adhesion molecule 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ncam1provided by MGI
Official Full Name: neural cell adhesion molecule 1provided by MGI
Primary source: MGI:97281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD56; Ncam; E-NCAM; NCAM-1

Genomic context

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Location :: 9 A5.3; 9 26.83 cM

Sequence :: Chromosome: 9; NC_000075.6 (49502138..49799069, complement)

See Ncam1 in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

In contrast to NCAM-deficient mice, NCAM+/- heterozygotic animals do not demonstrate memory impairment in either object recognition or contextual fear conditioning tests.
Title: Partial reduction in neural cell adhesion molecule (NCAM) in heterozygous mice induces depression-related behaviour without cognitive impairment.
Results indicate that the polySTs ST8SiaII and ST8SiaIV not only recognize an acidic patch in the FN1 domain of NCAM but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.
Title: The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation.
Our combined observations thus indicate that NCAM activates Pak-1 to drive actin polymerization to promote neuronal differentiation
Title: The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1).
alterations in PSA-NCAM levels were seen in the cerebral cortex immediately after injury, and these reductions persisted in brain regions distal to the primary injury site
Title: Mouse brain PSA-NCAM levels are altered by graded-controlled cortical impact injury.
The findings indicate that diminished NCAM expression might be a critical vulnerability factor for the development of behavioral alterations by stress and further support a functional involvement of NCAM in stress-induced cognitive and emotional disturbances.
Title: Vulnerability of conditional NCAM-deficient mice to develop stress-induced behavioral alterations.
NCAM deficiency impairs mesenchymal stromal cell motility.
Title: Neural cell adhesion molecule modulates mesenchymal stromal cell migration via activation of MAPK/ERK signaling.
NCAM180 regulates Ric8A membrane localization and potentiates beta-adrenergic response
Title: NCAM180 regulates Ric8A membrane localization and potentiates β-adrenergic response.
An abnormally high rate of postsynaptic membrane endocytosis may thus contribute to brain pathologies associated with mutations in NCAM or spectrin.
Title: NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation.
data suggest that affecting homeostasis of NCAM polysialylation may lead to alterations in precise neuronal circuit formation
Title: Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting.
In twelve-month-old NCAM-deficient (but not NCAM-positive) mice, hippocampal long-term potentiation is impaired by comparison with 3-month-old mice that could be rescued by d-cycloserine, a GluN2A agonist.
Title: Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors.

Submit: New GeneRIF Correction See all (70)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (4) 1 citation
Targeted (Reporter) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:201699	BioGRID:202389	Prnp	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201699	BioGRID:203459	Sptan1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201699	BioGRID:207648	Ywhab	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interferon gamma signaling, organism-specific biosystem (from REACTOME)
Interferon gamma signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L1CAM interactions, organism-specific biosystem (from REACTOME)
L1CAM interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
NCAM signaling for neurite out-growth, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NCAM1 interactions, organism-specific biosystem (from REACTOME)
NCAM1 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Prion diseases, organism-specific biosystem (from KEGG)
Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Prion diseases, conserved biosystem (from KEGG)
Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Signal transduction by L1, organism-specific biosystem (from REACTOME)
Signal transduction by L1, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:226059

D9Mit299 (e-PCR), detects polymorphism
- UniSTS:131868

Ncam (e-PCR), detects polymorphism
- UniSTS:158748

Ncam1 (e-PCR), detects polymorphism
- UniSTS:238142

D9Mit46 (e-PCR), detects polymorphism
- UniSTS:131935

Ncam (e-PCR), detects polymorphism
- UniSTS:226144

X15050 (e-PCR)
- UniSTS:125801

Ncam (e-PCR), detects polymorphism
- UniSTS:143991

Ncam (e-PCR), detects polymorphism
- UniSTS:143992

D9Mit94 (e-PCR), detects polymorphism
- UniSTS:131981

RH142318 (e-PCR)
- UniSTS:231565

D9Mit171 (e-PCR), detects polymorphism
- UniSTS:131727

D9Mit98 (e-PCR), detects polymorphism
- UniSTS:131985

D9Mit22 (e-PCR), detects polymorphism
- UniSTS:131779

D9Mit229 (e-PCR), detects polymorphism
- UniSTS:131791

Ncam1 (e-PCR), detects polymorphism
- UniSTS:532433

Homology

Homologs of the Ncam1 gene: The Ncam1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
LRR domain binding	ISO Inferred from Sequence Orthology more info
heparin binding	IEA Inferred from Electronic Annotation more info
phosphatase binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
aging	ISO Inferred from Sequence Orthology more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
homotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
learning or memory	ISO Inferred from Sequence Orthology more info
multicellular organismal response to stress	ISO Inferred from Sequence Orthology more info
negative regulation of cell death	ISO Inferred from Sequence Orthology more info
neuron development	ISO Inferred from Sequence Orthology more info
neuron projection development	IGI Inferred from Genetic Interaction more info
positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
regulation of exocyst assembly	IMP Inferred from Mutant Phenotype more info
regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
response to cocaine	ISO Inferred from Sequence Orthology more info
response to fluoxetine	ISO Inferred from Sequence Orthology more info
response to lead ion	ISO Inferred from Sequence Orthology more info
thalamus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
anchored to membrane	IEA Inferred from Electronic Annotation more info
axon	IDA Inferred from Direct Assay more info	PubMed
cell surface	ISO Inferred from Sequence Orthology more info
external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
growth cone	IDA Inferred from Direct Assay more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
neuronal cell body	ISO Inferred from Sequence Orthology more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neural cell adhesion molecule 1

Names: neural cell adhesion molecule 1; N-CAM-1

NP_001074914.1

EC 2.7.11.1

NP_001106675.1

EC 2.7.11.1

NP_035005.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081445.1 → NP_001074914.1 neural cell adhesion molecule 1 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 3. The encoded isoform (1), also known as NCAM-140, is shorter than isoform 3.

Source sequence(s)

AC117630, AK082621, CT025676

Consensus CDS

CCDS40617.1

UniProtKB/TrEMBL

E9QB01

UniProtKB/Swiss-Prot

P13595

Conserved Domains (6) summary

cd00063
Location:501 – 596
Blast Score: 130

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:423 – 493
Blast Score: 130

Ig; Immunoglobulin domain

cd05730
Location:211 – 308
Blast Score: 398

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 – 115
Blast Score: 482

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 – 403
Blast Score: 507

Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

pfam07679
Location:21 – 114
Blast Score: 206

I-set; Immunoglobulin I-set domain
NM_001113204.1 → NP_001106675.1 neural cell adhesion molecule 1 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3), also known as NCAM-180.

Source sequence(s)

AC117630, AK082621, CT025676, X15052

UniProtKB/Swiss-Prot

P13595

Conserved Domains (6) summary

cd00063
Location:501 – 596
Blast Score: 127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:423 – 493
Blast Score: 132

Ig; Immunoglobulin domain

cd05865
Location:20 – 115
Blast Score: 480

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 – 403
Blast Score: 503

Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

pfam07679
Location:21 – 114
Blast Score: 204

I-set; Immunoglobulin I-set domain

cl11960
Location:211 – 308
Blast Score: 392

Ig; Immunoglobulin domain
NM_010875.3 → NP_035005.2 neural cell adhesion molecule 1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site and polyadenylation site, compared to variant 3. The encoded isoform (2), also known as NCAM-120, has a shorter and distinct C-terminus compared to isoform 3.

Source sequence(s)

AC117630, AK051197, CT025676

Consensus CDS

CCDS40618.1

UniProtKB/TrEMBL

E9Q589

UniProtKB/Swiss-Prot

P13595

Conserved Domains (6) summary

cd00063
Location:501 – 596
Blast Score: 128

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:423 – 493
Blast Score: 129

Ig; Immunoglobulin domain

cd05730
Location:211 – 308
Blast Score: 401

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 – 115
Blast Score: 479

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 – 403
Blast Score: 505

Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

pfam07679
Location:21 – 114
Blast Score: 206

I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

49502138..49799069, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

46800549..47099090, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01077981.1 (613..21890)	None
genomic	AAHY01077982.1	None
genomic	AAHY01077983.1	None
genomic	AAHY01077984.1	None
genomic	AAHY01077985.1	None
genomic	AAHY01077986.1	None
genomic	AAHY01077987.1	None
genomic	AAHY01077988.1	None
genomic	AAHY01077989.1	None
genomic	AAHY01077990.1	None
genomic	AAHY01077991.1	None
genomic	AAHY01077992.1	None
genomic	AAHY01077993.1	None
genomic	AAHY01077994.1	None
genomic	AB001873.1	BAA31274.1	BALB/c
		BAA31275.1	BALB/c
genomic	AC117630.11 (55469..57912)	None
genomic	AC140447.3 (2633..158157)	None
genomic	CH466522.1	EDL25727.1	mixed
		EDL25728.1	mixed
		EDL25729.1	mixed
		EDL25730.1	mixed
		EDL25731.1	mixed
		EDL25732.1	mixed
genomic	CT025676.10 (59184..59330)	None
genomic	X07195.1	CAA30173.1
genomic	X07196.1	CAA30174.1
genomic	X07197.1	CAA30175.1
genomic	X07198.1	CAB40820.1
genomic	X07199.1	None
genomic	X07200.1	CAA30177.1
genomic	X14402.1	CAA32575.1	BALB/c
genomic	X14403.1	CAA32576.1	BALB/c
genomic	X14527.1	CAA32669.1	BALB/c
mRNA	AK011804.1	None	C57BL/6J
mRNA	AK011905.1	None	C57BL/6J
mRNA	AK034213.1	None	C57BL/6J
mRNA	AK051197.1	BAC34554.2	C57BL/6J
mRNA	AK053403.1	None	C57BL/6J
mRNA	AK082621.1	BAC38551.2	C57BL/6J
mRNA	AK219136.1	None
mRNA	BC011310.1	AAH11310.1	FVB/N
mRNA	BC062942.1	None	C57BL/6
mRNA	CD776219.1	None	C57BL/6J
mRNA	D13289.1	BAA28851.1
mRNA	X06328.1	CAA29641.1	C57BL/6
mRNA	X07233.1	None	C57BL/6
mRNA	X07244.1	CAA30230.1	C57BL/6J
mRNA	X14526.1	CAA32668.1	C57BL/6
mRNA	X15049.1	CAA33148.1	C57BL/6
mRNA	X15050.1	CAA33149.1	C57BL/6
mRNA	X15051.1	CAA33150.1	C57BL/6
mRNA	X15052.1	CAA33151.1	C57BL/6
mRNA	X59306.1	CAA41993.1
mRNA	Y00051.1	CAA68263.1	C57BL/6
mRNA	Y08360.1	CAA69647.1	C57BL/6