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Nbr1 neighbor of Brca1 gene 1 [ Mus musculus (house mouse) ]

Gene ID: 17966, updated on 28-May-2016
Official Symbol
Nbr1provided by MGI
Official Full Name
neighbor of Brca1 gene 1provided by MGI
Primary source
MGI:MGI:108498
See related
Ensembl:ENSMUSG00000017119 Vega:OTTMUSG00000002872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0049
Orthologs
Location:
11 D; 11 65.36 cM
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (101552107..101581951)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101414172..101443259)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11625 Neighboring gene breast cancer 1, early onset Neighboring gene transmembrane protein 106A Neighboring gene predicted gene 11634

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
macroautophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein oligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
pre-autophagosomal structure IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
next to BRCA1 gene 1 protein
Names
membrane component chromosome 17 surface marker 2 homolog
neighbor of BRCA1 gene 1 protein
next to the Brca1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252220.1NP_001239149.1  next to BRCA1 gene 1 protein isoform 1

    See identical proteins and their annotated locations for NP_001239149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC052709, BC129868, CJ303949, CO433793
    Consensus CDS
    CCDS25475.1
    UniProtKB/Swiss-Prot
    P97432
    UniProtKB/TrEMBL
    A1L329, Q05BC8
    Related
    ENSMUSP00000099388, OTTMUSP00000002775, ENSMUST00000103099, OTTMUST00000005874
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:938976
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  2. NM_001252222.1NP_001239151.1  next to BRCA1 gene 1 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK128992, BC052709, BC129867, CJ303949, CV558786
    Consensus CDS
    CCDS56811.1
    UniProtKB/TrEMBL
    A1L329, A2A4N8, Q05BC8
    Related
    ENSMUSP00000102831, OTTMUSP00000002777, ENSMUST00000107213, OTTMUST00000005876
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:901939
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  3. NM_001252223.1NP_001239152.1  next to BRCA1 gene 1 protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in frame-shift and early translation termination, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK129043, BC052709, CJ303949, CV558786
    Consensus CDS
    CCDS56810.1
    UniProtKB/TrEMBL
    A2A4N5, Q05BC8, Q6ZQK3
    Related
    ENSMUSP00000102826, OTTMUSP00000002779, ENSMUST00000107208, OTTMUST00000005878
    Conserved Domains (3) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  4. NM_008676.3NP_032702.1  next to BRCA1 gene 1 protein isoform 1

    See identical proteins and their annotated locations for NP_032702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    BC052709, BC129867, CJ303949, CV558786
    Consensus CDS
    CCDS25475.1
    UniProtKB/Swiss-Prot
    P97432
    UniProtKB/TrEMBL
    A1L329, Q05BC8
    Related
    ENSMUSP00000099387, OTTMUSP00000002776, ENSMUST00000103098, OTTMUST00000005875
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:938976
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    101552107..101581951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532431.1XP_006532494.1  

    See identical proteins and their annotated locations for XP_006532494.1

    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:944982
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  2. XM_006532430.1XP_006532493.1  

    See identical proteins and their annotated locations for XP_006532493.1

    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:944982
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  3. XM_006532434.1XP_006532497.1  

    Conserved Domains (3) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  4. XM_006532435.1XP_006532498.1  

    Conserved Domains (3) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  5. XM_006532432.1XP_006532495.1  

    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:908946
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  6. XM_006532433.1XP_006532496.1  

    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:902940
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RNA

  1. XR_388362.1 RNA Sequence

    Related
    ENSMUST00000123558, OTTMUST00000005877
  2. XR_388361.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    113239320..113269165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)