DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) [Homo sapiens] - Gene

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Summary

Official Symbol: DOK1provided by HGNC
Official Full Name: docking protein 1, 62kDa (downstream of tyrosine kinase 1)provided by HGNC
Primary source: HGNC:2990
See related: Ensembl:ENSG00000115325; HPRD:04228; MIM:602919; Vega:OTTHUMG00000129956
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P62DOK; MGC117395; MGC138860
Summary: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

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Genomic context

Location :: 2p13

Sequence :: Chromosome: 2; NC_000002.11 (74776147..74784678)

See DOK1 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hypermethylation of DOK1 is a potentially critical event in human carcinogenesis.
Title: Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers.
These findings are suggestive for a possible tumor suppressor role of DOK1 in epithelial ovarian cancer.
Title: Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer.
Cav1 cooperated with the endogenous Ras/MAPK inhibitor docking protein 1 (Dok1) to promote the ligand-dependent transcriptional activity of PPARgamma and to inhibit cell proliferation
Title: The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain.
these data support a model in which proteasome- mediated degradation of Dok-1 is an important contributive step toward tumor development and/or progression driven by OTKs
Title: Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation.
Dok1 negatively regulates Dok2-mediated CD200R signaling through the recruitment of CrkL.
Title: Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.
Identification of DOK genes as lung tumor suppressors.
Title: Identification of DOK genes as lung tumor suppressors.
The novel platelet adapter Dok-1 is tyrosine phosphorylated in an Src kinase-independent manner downstream of alphaIIbbeta3 in human platelets, leading to an interaction with Grb2 and SHIP-1.
Title: Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.
Results identified an N-terminally truncated isoform of human Dok-1 with N-terminal acetylation as seen in the wild-type.
Title: Targeted mass spectrometric analysis of N-terminally truncated isoforms generated via alternative translation initiation.
CD45 recruits adaptor DOK-1 to the proximal plasma membrane to serve as a downstream effector, resulting in negative regulation of the JAK/STAT signaling pathway.
Title: CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells.
Dok-1/Dok-2 pleckstrin homology domains bind in vitro to the rare phosphoinositide species, phosphatidylinositol 5-phosphate
Title: Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.

Submit: New GeneRIF Correction See all (25)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001372.1	NP_005532.2	INPP5D	BIND	PubMed	SHIP1 interacts with DOK1
NP_001372.1	NP_002881.1	RASA1	BIND	PubMed	DOK1 interacts with RASGAP
Q99704	P00519	ABL1	HPRD	PubMed
Q99704	P46109	CRKL	HPRD	PubMed
Q99704	P41240	CSK	HPRD	PubMed
Q99704	P07332	FES	HPRD	PubMed
Q99704	P09769	FGR	HPRD	PubMed
Q99704	P06241	FYN	HPRD	PubMed
Q99704	Q13322	GRB10	HPRD	PubMed
Q99704	P08631	HCK	HPRD	PubMed
Q99704	O00145	INPP5D	HPRD	PubMed
Q99704	P06213	INSR	HPRD	PubMed
Q99704	P05556	ITGB1	HPRD	PubMed
Q99704	P05107	ITGB2	HPRD	PubMed
Q99704	P05106	ITGB3	HPRD	PubMed
Q99704	P18084	ITGB5	HPRD	PubMed
Q99704	P26010	ITGB7	HPRD	PubMed
Q99704	P10721	KIT	HPRD	PubMed
Q99704	P06239	LCK	HPRD	PubMed
Q99704	P07948	LYN	HPRD	PubMed
Q99704	O95819	MAP4K4	HPRD	PubMed
Q99704	P16333	NCK1	HPRD	PubMed
Q99704	O43639	NCK2	HPRD	PubMed
Q99704	P19174	PLCG1	HPRD	PubMed
Q99704	P29350	PTPN6	HPRD	PubMed
Q99704	Protein tyrosine phosphatase receptor type H	PTPRH	HPRD	PubMed
Q99704	P20936	RASA1	HPRD	PubMed
Q99704	P07949	RET	HPRD	PubMed
Q99704	O60880	SH2D1A	HPRD	PubMed
Q99704	P29353	SHC1	HPRD	PubMed
Q99704	P12931	SRC	HPRD	PubMed
Q99704	P42680	TEC	HPRD	PubMed
Q99704	P07947	YES1	HPRD	PubMed
BioGRID:108131	BioGRID:106543	ABL1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:108131	BioGRID:107789	CRKL	BioGRID	PubMed	Reconstituted Complex
BioGRID:108131	BioGRID:108131	DOK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108131	BioGRID:114508	DOK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108131	BioGRID:108559	FGR	BioGRID	PubMed	Reconstituted Complex
BioGRID:108131	BioGRID:109305	HCK	BioGRID	PubMed	Reconstituted Complex
BioGRID:108131	BioGRID:109847	INPP5D	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108131	BioGRID:110015	KIT	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108131	BioGRID:110245	LYN	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:108131	BioGRID:114020	NCK2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108131	BioGRID:111313	PIK3R1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108131	BioGRID:111351	PLCG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108131	BioGRID:111856	RASA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108131	BioGRID:111911	RET	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:108131	BioGRID:110246	SH2D1A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108131	BioGRID:112361	SHC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108131	BioGRID:112592	SRC	BioGRID	PubMed	Reconstituted Complex
BioGRID:108131	BioGRID:112865	TEC	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:108131	BioGRID:113357	YES1	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
insulin receptor binding	IEA Inferred from Electronic Annotation more info
receptor signaling protein activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
insulin receptor signaling pathway	TAS Traceable Author Statement more info
intracellular protein kinase cascade	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: docking protein 1

Names: docking protein 1; pp62; p62(dok); Downstream of tyrosine kinase 1; docking protein 1 (downstream of tyrosine kinase 1)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197260.1 → NP_001184189.1 docking protein 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AF035299, BQ575925, DA382785

Consensus CDS

CCDS56125.1

UniProtKB/Swiss-Prot

Q99704

Related

ENSP00000387016, OTTHUMP00000202720, ENST00000409429, OTTHUMT00000328581

Conserved Domains (1) summary

cd01203
Location:13 – 120
Blast Score: 415

DOK_PTB; Downstream of tyrosine kinase (DOK) Phosphotyrosine-binding domain
NM_001381.3 → NP_001372.1 docking protein 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK055944, BQ575925, DA599419, U70987

Consensus CDS

CCDS1954.1

UniProtKB/TrEMBL

B3KP83

UniProtKB/Swiss-Prot

Q99704

Related

ENSP00000233668, OTTHUMP00000160414, ENST00000233668, OTTHUMT00000252218

Conserved Domains (2) summary

cd01203
Location:152 – 259
Blast Score: 416

DOK_PTB; Downstream of tyrosine kinase (DOK) Phosphotyrosine-binding domain

cl00273
Location:5 – 116
Blast Score: 89

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

74776147..74784678

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

74512408..74520939

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005033.1	AAX93224.1
genomic	CH471053.2	EAW99612.1
		EAW99613.1
		EAW99614.1
mRNA	AF035299.1	AAB88182.1
mRNA	AF180527.1	AAF19167.1
mRNA	AK055944.1	BAG51595.1
mRNA	AK127127.1	BAG54440.1
mRNA	AK127656.1	BAG54544.1
mRNA	AK222883.1	BAD96603.1
mRNA	AK296154.1	BAG58893.1
mRNA	AK300097.1	BAG61898.1
mRNA	AK314678.1	None
mRNA	BC111055.1	AAI11056.1
mRNA	BC114440.1	AAI14441.1
mRNA	BC114497.1	AAI14498.1
mRNA	BQ575925.1	None
mRNA	DA382785.1	None
mRNA	DA599419.1	None
mRNA	U70987.1	AAC51127.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q14CB2	GenPept	UniProtKB/TrEMBL:Q14CB2
Q2TA81	GenPept	UniProtKB/TrEMBL:Q2TA81
Q53GP8	GenPept	UniProtKB/TrEMBL:Q53GP8
Q99704.1	GenPept	UniProtKB/Swiss-Prot:Q99704