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DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) [ Homo sapiens (human) ]

Gene ID: 1796, updated on 30-Jun-2015
Official Symbol
DOK1provided by HGNC
Official Full Name
docking protein 1, 62kDa (downstream of tyrosine kinase 1)provided by HGNC
Primary source
HGNC:HGNC:2990
See related
Ensembl:ENSG00000115325; HPRD:04228; MIM:602919; Vega:OTTHUMG00000129956
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P62DOK
Summary
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Orthologs
See DOK1 in Epigenomics, MapViewer
Location:
2p13
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (74548205..74557551)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74776147..74784678)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene DEAQ box RNA-dependent ATPase 1 Neighboring gene ancient ubiquitous protein 1 Neighboring gene HtrA serine peptidase 2 Neighboring gene lysyl oxidase-like 3 Neighboring gene meiosis 1 associated protein Neighboring gene torsin family 1, member B (torsin B) pseudogene Neighboring gene TVP23B pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with docking protein 1 (DOK1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC117395, MGC138860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling protein activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
docking protein 1
Names
Downstream of tyrosine kinase 1
docking protein 1 (downstream of tyrosine kinase 1)
p62(dok)
pp62

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197260.1NP_001184189.1  docking protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001184189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF035299, BQ575925, DA382785
    Consensus CDS
    CCDS56125.1
    UniProtKB/Swiss-Prot
    Q99704
    Related
    ENSP00000387016, OTTHUMP00000202720, ENST00000409429, OTTHUMT00000328581
    Conserved Domains (1) summary
    cd01203
    Location:12114
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
  2. NM_001381.3NP_001372.1  docking protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK055944, BQ575925, DA599419, U70987
    Consensus CDS
    CCDS1954.1
    UniProtKB/TrEMBL
    B3KP83
    UniProtKB/Swiss-Prot
    Q99704
    Related
    ENSP00000233668, OTTHUMP00000160414, ENST00000233668, OTTHUMT00000252218
    Conserved Domains (2) summary
    cd01203
    Location:151253
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    pfam00169
    Location:5116
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    74548205..74557551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532670.1XP_011530972.1  

    Conserved Domains (2) summary
    cd01203
    Location:281383
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:151249
    PH-like; Pleckstrin homology-like domain
  2. XM_011532669.1XP_011530971.1  

    See identical proteins and their annotated locations for XP_011530971.1

    Conserved Domains (2) summary
    cd01203
    Location:140242
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:11108
    PH-like; Pleckstrin homology-like domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    74705542..74714073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)