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des-2 Acetylcholine receptor DES-2-like protein;Acetylcholine receptor subunit alpha-type des-2 [ Caenorhabditis elegans ]

Gene ID: 179574, updated on 11-Apr-2024

Summary

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Gene symbol
des-2
Gene description
Acetylcholine receptor DES-2-like protein;Acetylcholine receptor subunit alpha-type des-2
Primary source
WormBase:WBGene00000955
Locus tag
CELE_T26H10.1
See related
AllianceGenome:WB:WBGene00000955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable neurotransmitter receptor activity. Predicted to be involved in several processes, including chemical synaptic transmission; ion transmembrane transport; and regulation of membrane potential. Is integral component of plasma membrane. Is expressed in head neurons; interneuron; and pm1. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (11415272..11421705, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ground-like domain-containing protein Neighboring gene Acetylcholine receptor subunit alpha-type deg-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FRG domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans nicotinic acetylcholine receptors are required for nociception. Cohen E, et al. Mol Cell Neurosci, 2014 Mar. PMID 24518198, Free PMC Article
  2. The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Oren-Suissa M, et al. Science, 2010 Jun 4. PMID 20448153, Free PMC Article
  3. RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains. Ben-Ami HC, et al. J Biol Chem, 2005 Jul 29. PMID 15932871
  4. GFP is a selective non-linear optical sensor of electrophysiological processes in Caenorhabditis elegans. Khatchatouriants A, et al. Biophys J, 2000 Nov. PMID 11053114, Free PMC Article
  5. Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon. Treinin M, et al. Proc Natl Acad Sci U S A, 1998 Dec 22. PMID 9860996, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The conserved residues in the second RIC-3 transmembrane domain are needed for its interactions with DEG-3,DES-2 and ACR-16.
    Title: Receptor and subunit specific interactions of RIC-3 with nicotinic acetylcholine receptors.
  2. subunit-specific interactions of RIC-3 with nAChR subunits DEG-3/DES-2, mediated by the transmembrane domains, are sufficient for the effects of RIC-3 on nAChR quantity and quality
    Title: RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acetylcholine receptor DES-2-like protein;Acetylcholine receptor subunit alpha-type des-2
NP_001379140.1
  • Confirmed by transcript evidence
NP_001380111.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11415272..11421705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392615.1 → NP_001379140.1  Acetylcholine receptor subunit alpha-type des-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76554
    Conserved Domains (3) summary
    cd19051
    Location:239 → 332
    LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
    pfam02931
    Location:28 → 222
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:245 → 531
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001392616.1 → NP_001380111.1  Acetylcholine receptor DES-2-like protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2Y4
    Conserved Domains (2) summary
    cd19051
    Location:239 → 332
    LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
    pfam02931
    Location:28 → 222
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76554.1

Gene LinkOut

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