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DOCK3 dedicator of cytokinesis 3 [ Homo sapiens (human) ]

Gene ID: 1795, updated on 8-May-2016
Official Symbol
DOCK3provided by HGNC
Official Full Name
dedicator of cytokinesis 3provided by HGNC
Primary source
HGNC:HGNC:2989
See related
Ensembl:ENSG00000088538 HPRD:10341; MIM:603123; Vega:OTTHUMG00000156892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBP; MOCA
Summary
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
Orthologs
Location:
3p21.2
Exon count:
59
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (50674969..51384198)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50712672..51421629)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase-activated protein kinase 3 Neighboring gene cytokine inducible SH2 containing protein Neighboring gene microRNA 4787 Neighboring gene zinc finger protein 652 pseudogene 1 Neighboring gene suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 14 Neighboring gene RNA binding motif protein 15B Neighboring gene Vpr (HIV-1) binding protein Neighboring gene mesencephalic astrocyte derived neurotrophic factor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Identification of a melanoma susceptibility locus and somatic mutation in TET2.
NHGRI GWA Catalog
  • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
    BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0299

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
dedicator of cytokinesis protein 3
Names
modifier of cell adhesion
presenilin-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028012.1 RefSeqGene

    Range
    5001..713958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004947.4NP_004938.1  dedicator of cytokinesis protein 3

    See identical proteins and their annotated locations for NP_004938.1

    Status: REVIEWED

    Source sequence(s)
    AY254099, BC045793
    Consensus CDS
    CCDS46835.1
    UniProtKB/Swiss-Prot
    Q8IZD9
    Related
    ENSP00000266037, OTTHUMP00000216674, ENST00000266037, OTTHUMT00000346478
    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    50674969..51384198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533446.1XP_011531748.1  

    Conserved Domains (2) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
  2. XM_005264915.2XP_005264972.1  

    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
  3. XM_006713008.2XP_006713071.1  

    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
  4. XM_006713009.2XP_006713072.1  

    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    cl06123
    Location:12351597
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
  5. XM_005264914.2XP_005264971.1  

    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
  6. XM_005264916.2XP_005264973.1  

    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12261617
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
  7. XM_005264917.2XP_005264974.1  

    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12211612
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
  8. XM_005264918.2XP_005264975.1  

    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:11861577
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
  9. XM_006713010.2XP_006713073.1  

    Conserved Domains (3) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
  10. XM_011533441.1XP_011531743.1  

    Conserved Domains (2) summary
    cd08695
    Location:75264
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:8901281
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
  11. XM_011533442.1XP_011531744.1  

    Conserved Domains (1) summary
    cd11704
    Location:485876
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
  12. XM_011533443.1XP_011531745.1  

    See identical proteins and their annotated locations for XP_011531745.1

    Conserved Domains (2) summary
    cd11704
    Location:339730
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cl09913
    Location:233349
    Csn2_like; CRISPR/Cas system-associated protein Csn2
  13. XM_011533444.1XP_011531746.1  

    See identical proteins and their annotated locations for XP_011531746.1

    Conserved Domains (2) summary
    cd11704
    Location:339730
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cl09913
    Location:233349
    Csn2_like; CRISPR/Cas system-associated protein Csn2
  14. XM_011533445.1XP_011531747.1  

    Conserved Domains (2) summary
    cd11704
    Location:281672
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cl09913
    Location:175291
    Csn2_like; CRISPR/Cas system-associated protein Csn2

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    50664865..51373537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)