Myog myogenin [Mus musculus] - Gene

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Summary

Official Symbol: Myogprovided by MGI
Official Full Name: myogeninprovided by MGI
Primary source: MGI:97276
See related: Ensembl:ENSMUSG00000026459
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: myo; MYF4; bHLHc3

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Genomic context

Location :: 1 E4; 1 72.3 cM

Sequence :: Chromosome: 1; NC_000067.6 (134290004..134292548)

See Myog in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the important role of myogenin in maintaining terminal muscle cell differentiation
Title: Down-regulation of myogenin can reverse terminal muscle cell differentiation.
TEAD factors directly induce Myogenin, CDKN1A and Caveolin 3 expression to promote myoblast differentiation.
Title: Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation.
Ptpla regulates myogenesis through Myog.
Title: Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway.
Myog and the signaling cascades regulating its induction following muscle denervation may represent novel targets for therapies aimed at reducing denervation-induced muscle atrophy.
Title: Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle.
suggest a novel mechanism for transcriptional repression by TSHZ3 in which TSHZ3 and BAF57 cooperate to modulate MyoD activity on the Myog promoter to regulate skeletal muscle differentiation.
Title: Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression.
myogenin was dispensable for muscle regeneration. Factors associated with muscle fatigue, metabolism, and proteolysis were significantly altered in mdx:Myog-deleted mice
Title: Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice.
CTCF enhances the myogenic potential of MyoD and myogenin and establishes direct interactions with MyoD, indicating that CTCF regulates MRF-mediated muscle differentiation.
Title: CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors.
alpha-syntrophin plays an important role in regulating myogenesis by modulating myogenin expression
Title: Α-syntrophin modulates myogenin expression in differentiating myoblasts.
Results analyze the DNA methylation pattern of the 5'-flanking of the myogenin gene, a positive regulator of muscle differentiation with no CpG island and low CpG density, in both C2C12 muscle satellite cells and embryonic muscle.
Title: Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation.
Myogenin plays a dual role as both a regulator of muscle development and an inducer of neurogenic atrophy
Title: Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases.

Submit: New GeneRIF Correction See all (42)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation
Targeted (knock-in) (2) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NT_039180.3			BIND	PubMed	The MyoD/E12 heterodimer interacts with the myogenin promoter.
NT_039180.3			BIND	PubMed	The Pbx1b/Meis1 heterodimer interacts with the myogenin promoter.
BioGRID:201674	BioGRID:205088	Cul1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:201674	BioGRID:214895	Cul2	BioGRID	PubMed	Reconstituted Complex
BioGRID:201674	BioGRID:125185	EGLN3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:201674	BioGRID:227483	Egln3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201674	BioGRID:212401	Fbxo32	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201674	BioGRID:203998	Skp1a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201674	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201674	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201674	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
core promoter proximal region sequence-specific DNA binding	IDA Inferred from Direct Assay more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
ossification	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
skeletal muscle tissue development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: myogenin

Names: myogenin; MYOD1-related protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031189.2 → NP_112466.1 myogenin

Status: VALIDATED

Source sequence(s)

BC048683, CJ096370

Consensus CDS

CCDS15306.1

UniProtKB/Swiss-Prot

P12979

Related

ENSMUSP00000027730, ENSMUST00000027730

Conserved Domains (2) summary

cd00083
Location:97 – 137
Blast Score: 111

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cl11603
Location:1 – 81
Blast Score: 303

Basic; Myogenic Basic domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38 C57BL/6J

Range

134290004..134292548

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

136900556..136903100

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC124110.8 (70119..72656)	None
genomic	CH466520.2	EDL39619.1	mixed
		EDL39620.1	mixed
genomic	M95800.1	AAB59676.1	DBA/2J
genomic	X71910.1	CAA50725.1	C57BL/6
mRNA	AB221643.1	None
mRNA	BC048683.1	AAH48683.1
mRNA	BC068019.1	AAH68019.1
mRNA	CJ096370.1	None
mRNA	D90156.1	BAA14187.1
mRNA	X15784.1	CAA33785.1	BALB/c