Myh9 myosin, heavy polypeptide 9, non-muscle [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Myh9provided by MGI
Official Full Name: myosin, heavy polypeptide 9, non-muscleprovided by MGI
Primary source: MGI:107717
Locus tag: AL583886.1
See related: Ensembl:ENSMUSG00000022443; Vega:OTTMUSG00000016428
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fltn; Myhn1; C80049; D0Jmb2; Myhn-1; TU72.6; NMHCIIA; NMMHC-A; NMHC II-A; NMMHC-IIA; NMMHC II-a; E030044M24Rik

Genomic context

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Location :: 15 E1; 15 36.81 cM

Sequence :: Chromosome: 15; NC_000081.6 (77760589..77842115, complement)

See Myh9 in Epigenomics, MapViewer

Chromosome 15 - NC_000081.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

MIIA is required for efficient cell migration in restricted environments as well as for adhesion maturation.
Title: Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics.
Myosin IIA inhibition also significantly reduces phosphorylation of the mechanosensing protein CasL (Crk-associated substrate the lymphocyte type), raising the possibility of a direct mechanical mechanism of signal modulation involving CasL.
Title: Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation.
Mutations in MYH9 is associated with hematologic, eye, and kidney abnormalities
Title: Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.
Data show that CXCL13/CXCR5 facilitated antigen encounter and BCR signaling by promoting membrane ruffling and LFA-1-supported adhesion require a functional actin cytoskeleton and the activity of the motor protein non-muscle myosin II (NM-II).
Title: CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics.
Myh9 podocyte deletion in C57BL/6 mice results in susceptibility to experimental doxorubicin hydrochloride glomerulopathy
Title: Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy.
myosin IIA and IIB are differentially expressed and localized and have clearly different functions in hepatic stellate cells
Title: Distinct roles for non-muscle myosin II isoforms in mouse hepatic stellate cells.
thrombocytopenia in Myh9Delta mice results from defective development of megakaryocyte size, impaired proplatelet formation and increased cell death
Title: Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.
mutated non-muscle myosin IIA can lead to thrombocytopenia in mice and humans
Title: The value of a native milieu: mutated non-muscle myosin IIA does lead to thrombocytopenia.
Loss of myosin II, VI or VIIa function had no significant effects on rates of endocytic vesicle movement in bone marrow-derived dendritic cells.[myo2a or Non muscle myosin II]
Title: Assessment of myosin II, Va, VI and VIIa loss of function on endocytosis and endocytic vesicle motility in bone marrow-derived dendritic cells.
Myosin IIA optimizes lymphocyte crawling efficiency in the many environments T cells must pass through during their trafficking.
Title: Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions.

Submit: New GeneRIF Correction See all (30)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (3) 1 citation
Targeted (knock-out) (1) 1 citation
Targeted (Reporter) (4) 1 citation
Gene trapped (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:201650	BioGRID:222112	E130012A19Rik	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:200780	Invs	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:235913	Iqcb1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:201176	Lmna	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:207511	Nphp1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:234431	Nphp4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:202211	Pknox1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:220011	Rnf123	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:119029	SH3KBP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:241694	Trim72	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201650	BioGRID:204623	Ywhaz	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
Sema4D in semaphorin signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Semaphorin interactions, organism-specific biosystem (from REACTOME)
Semaphorin interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Tight junction, organism-specific biosystem (from KEGG)
Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tight junction, conserved biosystem (from KEGG)
Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Translocation of GLUT4 to the Plasma Membrane, organism-specific biosystem (from REACTOME)
Translocation of GLUT4 to the Plasma Membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237340

C80049 (e-PCR)
- UniSTS:165947

NoName (e-PCR)
- UniSTS:488295

Homology

Homologs of the Myh9 gene: The Myh9 gene is conserved in human, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ADP binding	ISO Inferred from Sequence Orthology more info
ATP binding	ISO Inferred from Sequence Orthology more info
ATPase activity	ISO Inferred from Sequence Orthology more info
actin binding	ISO Inferred from Sequence Orthology more info
actin filament binding	ISO Inferred from Sequence Orthology more info
actin-dependent ATPase activity	ISO Inferred from Sequence Orthology more info
calmodulin binding	IEA Inferred from Electronic Annotation more info
follicle-stimulating hormone receptor binding	ISO Inferred from Sequence Orthology more info
microfilament motor activity	ISO Inferred from Sequence Orthology more info
motor activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein anchor	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
ATP catabolic process	ISO Inferred from Sequence Orthology more info
actin cytoskeleton reorganization	ISO Inferred from Sequence Orthology more info
actin filament-based movement	ISO Inferred from Sequence Orthology more info
angiogenesis	ISO Inferred from Sequence Orthology more info
blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
cell morphogenesis involved in differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
cellular component movement	IMP Inferred from Mutant Phenotype more info	PubMed
cytokinesis	ISO Inferred from Sequence Orthology more info
establishment of T cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
establishment of meiotic spindle localization	IDA Inferred from Direct Assay more info	PubMed
in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
meiotic metaphase I	IDA Inferred from Direct Assay more info	PubMed
meiotic spindle organization	IDA Inferred from Direct Assay more info	PubMed
membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
platelet formation	ISO Inferred from Sequence Orthology more info
positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
protein transport	ISO Inferred from Sequence Orthology more info
regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell shape	ISO Inferred from Sequence Orthology more info
uropod organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
actin cytoskeleton	ISO Inferred from Sequence Orthology more info
actomyosin contractile ring	ISO Inferred from Sequence Orthology more info
cell cortex	IDA Inferred from Direct Assay more info	PubMed
cell leading edge	ISO Inferred from Sequence Orthology more info
cell-cell adherens junction	IDA Inferred from Direct Assay more info	PubMed
cleavage furrow	ISO Inferred from Sequence Orthology more info
cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with endosome	ISO Inferred from Sequence Orthology more info
extracellular vesicular exosome	ISO Inferred from Sequence Orthology more info
colocalizes_with immunological synapse	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with immunological synapse	ISO Inferred from Sequence Orthology more info
lateral plasma membrane	ISO Inferred from Sequence Orthology more info
myosin II complex	IDA Inferred from Direct Assay more info
myosin complex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
colocalizes_with phagocytic vesicle	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info
ruffle	ISO Inferred from Sequence Orthology more info
colocalizes_with spindle	IDA Inferred from Direct Assay more info	PubMed
stress fiber	IDA Inferred from Direct Assay more info	PubMed
stress fiber	ISO Inferred from Sequence Orthology more info
uropod	IDA Inferred from Direct Assay more info	PubMed
uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-9

Names: myosin-9; flectin; myosin IIA; myosin heavy chain 9; myosin heavy chain IX; non-muscle myosin heavy chain A; non-muscle myosin heavy chain IIa; myosin heavy chain, non-muscle IIa; cellular myosin heavy chain, type A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022410.2 → NP_071855.2 myosin-9 isoform 1

Status: PROVISIONAL

Source sequence(s)

AK147208

Consensus CDS

CCDS27605.1

UniProtKB/Swiss-Prot

Q8VDD5

Related

ENSMUSP00000016771, OTTMUSP00000017674, ENSMUST00000016771, OTTMUST00000039563

Conserved Domains (5) summary

cd01377
Location:77 – 775
Blast Score: 3144

MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...

pfam02736
Location:29 – 71
Blast Score: 125

Myosin_N; Myosin N-terminal SH3-like domain

pfam01576
Location:1091 – 1923
Blast Score: 1185

Myosin_tail_1; Myosin tail

smart00242
Location:76 – 776
Blast Score: 2608

MYSc; Myosin. Large ATPases.

cl00240
Location:1206 – 1263
Blast Score: 93

RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000081.6 Reference GRCm38.p1 C57BL/6J

Range

77760589..77842115, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000037.1 Alternate Mm_Celera

Range

79227040..79308545, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01123599.1 (39356..120861)	None
genomic	AL583886.11 (99864..181390)	None
genomic	CH466545.1	EDL29650.1	mixed
mRNA	AJ312390.1	CAC85955.1
mRNA	AK040822.1	BAC30712.1	C57BL/6J
mRNA	AK053221.1	None	C57BL/6J
mRNA	AK083071.1	BAC38752.1	C57BL/6J
mRNA	AK087164.1	None	C57BL/6J
mRNA	AK131171.1	BAD21421.1
mRNA	AK147203.1	BAE27761.1	C57BL/6J
mRNA	AK147206.1	BAE27763.1	C57BL/6J
mRNA	AK147208.1	BAE27765.1	C57BL/6J
mRNA	AK147209.1	BAE27766.1	C57BL/6J
mRNA	AK147210.1	BAE27767.1	C57BL/6J
mRNA	AK147211.1	BAE27768.1	C57BL/6J
mRNA	AK147215.1	BAE27772.1	C57BL/6J
mRNA	AK147216.1	BAE27773.1	C57BL/6J
mRNA	AK147221.1	BAE27776.1	C57BL/6J
mRNA	AK147222.1	BAE27777.1	C57BL/6J
mRNA	AK147223.1	BAE27778.1	C57BL/6J
mRNA	AK147233.1	BAE27783.1	C57BL/6
mRNA	AK147235.1	BAE27785.1	C57BL/6
mRNA	AK147296.1	BAE27829.1	C57BL/6
mRNA	AK147407.1	BAE27894.1	C57BL/6J
mRNA	AK147430.1	BAE27906.1	C57BL/6J
mRNA	AK148323.1	BAE28480.1	C57BL/6J
mRNA	AK165379.1	None	C57BL/6J
mRNA	AK178127.1	None
mRNA	BC006075.1	AAH06075.1	FVB/N
mRNA	BC026521.1	None	FVB/N
mRNA	BC043703.1	AAH43703.1	FVB/N
mRNA	BC044834.1	AAH44834.1	FVB/N
mRNA	BC054360.1	AAH54360.1	FVB/N
mRNA	BC116417.1	AAI16418.1
mRNA	BC116418.1	AAI16419.1
mRNA	BC128059.1	AAI28060.1
mRNA	BC128497.1	AAI28498.1
mRNA	BC128498.1	AAI28499.1
mRNA	M88754.1	None	C3H/HeJ
mRNA	U89401.1	AAC36508.1	BALB/c