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    Gadd45b growth arrest and DNA-damage-inducible 45 beta [ Mus musculus ]

    Gene ID: 17873, updated on 19-May-2012
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    Summary

    Official Symbol
    Gadd45bprovided by MGI
    Official Full Name
    growth arrest and DNA-damage-inducible 45 betaprovided by MGI
    Primary source
    MGI:107776
    See related
    Ensembl:ENSMUSG00000015312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myd118; AI323528
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    Genomic context

    Location :
    10 C1; 10 60.5 cM
    Sequence :
    Chromosome: 10; NC_000076.6 (80930091..80932204)
    See Gadd45b in Epigenomics, MapViewer

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 9 Neighboring gene translocase of inner mitochondrial membrane 13 homolog (yeast) Neighboring gene lamin B2 Neighboring gene guanine nucleotide binding protein (G protein), gamma 7 Neighboring gene DIRAS family, GTP-binding RAS-like 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice. Tian J, et al. J Clin Invest, 2011 Nov. PMID 21965327.
    2. Defining the molecular character of the developing and adult kidney podocyte. Brunskill EW, et al. PLoS One, 2011. PMID 21931791.
    3. IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. Yang Q, et al. Eur J Immunol, 2011 Nov. PMID 21887788.
    4. Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development. Kaufmann LT, et al. Gene Expr Patterns, 2011 Dec. PMID 21843656.
    5. Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice. Shimada H, et al. Pathol Res Pract, 2011 Apr 15. PMID 21353395.

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
      Title: Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
    2. defined separate Gadd45beta domains that mediated binding to CAR and transcriptional activation
      Title: Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice.
    3. The synergism between GADD45beta and C/EBPbeta may play an important role in cellular senescence in the aging articular cartilage.
      Title: Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice.
    4. Gadd45b was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions.
      Title: Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
    5. CAR may repress death of mouse primary hepatocytes by forming a GADD45B complex and repressing MKK7-mediated phosphorylation of JNK1
      Title: Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B.
    6. Findings suggest that Gadd45b mediates p38-induced Rb phosphorylation by enhancing the interaction between p38 and Rb during Fas-induced apoptosis in murine hepatocytes.
      Title: Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor.
    7. we have uncovered a novel molecular mechanism linking GADD45beta via the MTK1/MKK3/6/p38 axis to C/EBPbeta-TAD4 activation of Col10a1 transcription in terminally differentiating chondrocytes
      Title: GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes.
    8. members of the Gadd45 gene family are important for anti-tumor immune responses.
      Title: Gadd45b and Gadd45g are important for anti-tumor immune responses.
    9. Deficient Gadd45beta expression in RA can contribute to activation of JNK, exacerbate clinical arthritis, and augment joint destruction.
      Title: Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling.
    10. study identifes Gadd45b as a neural activity-induced immediate early gene in mature hippocampal neurons; Gadd45b is required for activity-induced DNA demethylation of specific promoters and expression of corresponding genes critical for adult neurogenesis
      Title: Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis.
    Submit: New GeneRIF Correction See all (31)
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_032681.1     BIND  PubMed The Cdk1/Cyclin B1 complex interacts with Gadd45b. 
    BioGRID:201638 BioGRID:108403 ESR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:201638 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:201638 BioGRID:111461 PPARA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:201638 BioGRID:111463 PPARD    BioGRID  PubMed Reconstituted Complex 
    BioGRID:201638 BioGRID:111464 PPARG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:201638 BioGRID:111849 RARA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:201638 BioGRID:112168 RXRA    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    growth arrest and DNA damage-inducible protein GADD45 beta
    Names
    growth arrest and DNA damage-inducible protein GADD45 beta
    negative growth regulatory protein MyD118
    myeloid differentiation primary response gene 118
    myeloid differentiation primary response protein MyD118
    growth arrest and DNA-damage-inducible protein GADD45 beta
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008655.1 → NP_032681.1  growth arrest and DNA damage-inducible protein GADD45 beta

      Status: PROVISIONAL

      Source sequence(s)
      X54149
      Consensus CDS
      CCDS24038.1
      UniProtKB/Swiss-Prot
      P22339
      Related
      ENSMUSP00000015456, ENSMUST00000015456
      Conserved Domains (1) summary
      cl00600
      Location:21 – 120
      Blast Score: 124
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38 C57BL/6J

      Range
      80930091..80932204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      81949491..81951604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AC091518.22 (109305..111418) None 129/SvJ
    genomic AC152413.5 (180183..182296) None
    genomic AF176045.3 AAD51080.2 129/Sv
    genomic AF441860.1 AAN23034.1 129/SvJ
    genomic CH466553.2 EDL31471.1 mixed
    mRNA AK010420.1 BAB26923.1 C57BL/6J
    mRNA AK149895.1 BAE29151.1 C57BL/6J
    mRNA AK154952.1 BAE32947.1 NOD
    mRNA AK186667.1 None
    mRNA BC023815.1 AAH23815.1 FVB/N
    mRNA X54149.1 CAA38088.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22339.1 GenPept UniProtKB/Swiss-Prot:P22339
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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