TRDMT1 tRNA aspartic acid methyltransferase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: TRDMT1provided by HGNC
Official Full Name: tRNA aspartic acid methyltransferase 1provided by HGNC
Primary source: HGNC:2977
Locus tag: RP11-406H21.1
See related: Ensembl:ENSG00000107614; HPRD:16001; MIM:602478; Vega:OTTHUMG00000017745
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DMNT2; DNMT2; PUMET; RNMT1; MHSAIIP
Summary: This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]

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Genomic context

Location :: 10p15.1

Sequence :: Chromosome: 10; NC_000010.10 (17184982..17244070, complement)

See TRDMT1 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection.
Title: The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress.
The expression of DNMT1, DNMT2, DNMT3A and DNMT3B in pediatric acute lymphoblastic leukemia patients, was investigated.
Title: DNA methyltransferase expression differs with proliferation in childhood acute lymphoblastic leukemia.
Hepatitis B virus-induced overexpression of DNMTs leads to viral DNA methylation and decreased viral gene expression and also leads to methylation of host CpG islands.
Title: Hepatitis B virus replication induces methylation of both host and viral DNA.
An association study of 45 folate-related genes in spina bifida: Involvement of tRNA aspartic acid methyltransferase 1 (TRDMT1)
Title: An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
cDNA microarray analysis identified several genes involved in DNA methylation, such as DNMT2 and DNMT3a that were more highly expressed in LNCaP-r (an androgen sensitive prostate cancer cell line).
Title: Cytogenetic and expression profiles associated with transformation to androgen-resistant prostate cancer.
genetic and biochemical approach revealed that DNMT2 did not methylate DNA but instead methylated aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop
Title: Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
identification of residual DNA-(cytosine-C5) methyltransferase activity
Title: The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
O14717	Q7L5N1	COPS6	HPRD	PubMed
O14717	Q9GZR7	DDX24	HPRD	PubMed
O14717	P68104	EEF1A1	HPRD	PubMed
O14717	Q5T3J3	LRIF1	HPRD	PubMed
O14717	Hypothetical protein DKFZp564O0523	RBM48	HPRD	PubMed
O14717	Q15047	SETDB1	HPRD	PubMed
O14717	Q16623	STX1A	HPRD	PubMed
O14717	Q13432	UNC119	HPRD	PubMed
O14717	Q9BVJ6	UTP14A	HPRD	PubMed
BioGRID:108124	BioGRID:116176	COPS6	BioGRID	PubMed	Two-hybrid
BioGRID:108124	BioGRID:121353	DDX24	BioGRID	PubMed	Two-hybrid
BioGRID:108124	BioGRID:108237	EEF1A1	BioGRID	PubMed	Two-hybrid
BioGRID:108124	BioGRID:120905	LRIF1	BioGRID	PubMed	Two-hybrid
BioGRID:108124	BioGRID:123855	RBM48	BioGRID	PubMed	Two-hybrid
BioGRID:108124	BioGRID:115202	SETDB1	BioGRID	PubMed	Two-hybrid
BioGRID:108124	BioGRID:112676	STX1A	BioGRID	PubMed	Two-hybrid
BioGRID:108124	BioGRID:114548	UNC119	BioGRID	PubMed	Two-hybrid
BioGRID:108124	BioGRID:116026	UTP14A	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA (cytosine-5-)-methyltransferase activity	TAS Traceable Author Statement more info	PubMed
DNA binding	IEA Inferred from Electronic Annotation more info
RNA binding	IEA Inferred from Electronic Annotation more info
methyltransferase activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
C-5 methylation of cytosine	TAS Traceable Author Statement more info	PubMed
DNA methylation	IEA Inferred from Electronic Annotation more info
response to amphetamine	IEA Inferred from Electronic Annotation more info
tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tRNA (cytosine(38)-C(5))-methyltransferase

Names: tRNA (cytosine(38)-C(5))-methyltransferase; DNA methyltransferase-2; DNA MTase homolog HsaIIP; tRNA (cytosine-5-)-methyltransferase; DNA (cytosine-5)-methyltransferase-like protein 2

NP_004403.1

EC 2.1.1.204

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004412.5 → NP_004403.1 tRNA (cytosine(38)-C(5))-methyltransferase

Status: REVIEWED

Source sequence(s)

AC067747, AJ223333, AL133415, BU620523, DC411638

Consensus CDS

CCDS7114.1

UniProtKB/Swiss-Prot

O14717

UniProtKB/TrEMBL

Q6ICS7

Related

ENSP00000367030, OTTHUMP00000019228, ENST00000377799, OTTHUMT00000047024

Conserved Domains (3) summary

cd00315
Location:4 – 179
Blast Score: 460

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

TIGR00675
Location:6 – 387
Blast Score: 252

dcm; DNA-methyltransferase (dcm)

cl16911
Location:260 – 391
Blast Score: 184

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

17184982..17244070, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

17098163..17157293, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_176081.2: Suppressed sequence

Description

NM_176081.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_176083.2: Suppressed sequence

Description

NM_176083.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_176084.1: Suppressed sequence

Description

NM_176084.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_176085.1: Suppressed sequence

Description

NM_176085.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_176086.1: Suppressed sequence

Description

NM_176086.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC067747.7	None
genomic	AL133415.13	CAB87964.1
		CAI39482.1
		CAI39483.1
		CAI39484.1
genomic	CH471072.2	EAW86217.1
		EAW86218.1
		EAW86219.1
genomic	EF444974.1	ACA05981.1
		ACA05982.1
		ACA05983.1
		ACA05984.1
		ACA05986.1
		ACA05987.1
mRNA	AF012128.1	AAC51939.1
mRNA	AF045888.1	AAC39764.1
mRNA	AF329940.1	AAK68034.1
mRNA	AF329941.1	AAK68035.1
mRNA	AF329942.1	AAK68036.1
mRNA	AF329943.1	AAK68037.1
mRNA	AF329944.1	AAK68033.1
mRNA	AJ223333.1	CAA11272.1
mRNA	AK021659.1	None
mRNA	AK291417.1	BAF84106.1
mRNA	AK294100.1	BAH11673.1
mRNA	AK299027.1	BAG61104.1
mRNA	AK303428.1	BAH13958.1
mRNA	BC047733.1	AAH47733.1
mRNA	BU620523.1	None
mRNA	BX537961.1	CAD97925.1
mRNA	CR450316.1	CAG29312.1
mRNA	DC411638.1	None

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O14717.1	GenPept	UniProtKB/Swiss-Prot:O14717
Q5JVT2	GenPept	UniProtKB/TrEMBL:Q5JVT2
Q5JVT3	GenPept	UniProtKB/TrEMBL:Q5JVT3
Q5JVT4	GenPept	UniProtKB/TrEMBL:Q5JVT4
Q6ICS7	GenPept	UniProtKB/TrEMBL:Q6ICS7
Q7Z3E4	GenPept	UniProtKB/TrEMBL:Q7Z3E4