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    Myc myelocytomatosis oncogene [ Mus musculus (house mouse) ]

    Gene ID: 17869, updated on 12-May-2013
    Official Symbol
    Mycprovided by MGI
    Official Full Name
    myelocytomatosis oncogeneprovided by MGI
    Primary source
    MGI:97250
    See related
    Ensembl:ENSMUSG00000022346; Vega:OTTMUSG00000034892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myc2; Nird; Niard; bHLHe39; AU016757
    Summary
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
    Location :
    15 D2-D3; 15 26.19 cM
    Sequence :
    Chromosome: 15; NC_000081.6 (61985341..61990361)
    See Myc in Epigenomics, MapViewer

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene MIS12 homolog pseudogene Neighboring gene zinc finger, CCHC domain containing 9 pseudogene Neighboring gene plasmacytoma variant translocation 1 Neighboring gene H2A histone family, member Y3 Neighboring gene predicted gene, 20175

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Direct reprogramming by oncogenic Ras and Myc. Ischenko I, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23431158.
    2. The transcription factor Otx2 regulates choroid plexus development and function. Johansson PA, et al. Development, 2013 Mar. PMID 23364326.
    3. 53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma. Jankovic M, et al. Mol Cell, 2013 Feb 21. PMID 23290917.
    4. Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy. Takahashi Y, et al. Blood, 2013 Feb 28. PMID 23287860.
    5. Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Zhang Q, et al. Proc Natl Acad Sci U S A, 2013 Jan 15. PMID 23277542.

    See all (789) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data indicate that ectopic MYC expression shows promise for restoring proliferative capacity to inner ear sensory epithelia and may be used to stimulate regeneration.
      Title: MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro.
    2. Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesis
      Title: Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesis.
    3. metastatic conversion of KrasG12D-expressing cells that exhibit different degrees of differentiation and malignancy can be reconstructed in cell culture, and the proto-oncogene c-Myc controls the generation of self-renewing metastatic cancer
      Title: Direct reprogramming by oncogenic Ras and Myc.
    4. Transforming growth factor-beta directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas
      Title: Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
    5. Bif-1 haploinsufficiency attenuates mitophagy and results in the promotion of chromosomal instability, which enables tumor cells to efficiently bypass the oncogenic/metabolic pressures for apoptosis.
      Title: Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy.
    6. Activation of the Wnt/beta-catenin pathway could promote the proliferation and inhibit the differentiation of mouse teratocarcinoma cells by upregulation of c-myc expression.
      Title: Wnt/β-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells.
    7. c-Myc is a direct regulator of Parp1
      Title: Poly(ADP-ribose) polymerase 1 regulates nuclear reprogramming and promotes iPSC generation without c-Myc.
    8. To further understand how c-Myc switches from an oncogenic protein to an apoptotic protein, we examined the mechanism of p53-independent c-Myc-induced apoptosis.
      Title: Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity.
    9. Data from knockout mice suggest that Bmyc (brain expressed myelocytomatosis oncogene protein) is a regulator of Myc in vivo and that overexpression of Myc in developing testis leads to increased apoptosis of spermatogenic cells.
      Title: Loss of Bmyc results in increased apoptosis associated with upregulation of Myc expression in juvenile murine testis.
    10. Pathway activation was induced in a Myc immortalised cerebellar progenitor cell line through stable expression of Wnt1.
      Title: WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.
    Submit: New GeneRIF Correction See all (308)
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    NP_034979.2 AC140347.3 Adm    BIND  PubMed Myc interacts with the Adm promoter. 
    NP_034979.2 AF339055.1 Bax    BIND  PubMed Myc interacts with the Bax promoter. 
    NP_034979.2 NC_000072.1 Bcat1    BIND  PubMed Myc interacts with the Bcat1 (Eca39) promoter. 
    NP_034979.2 NC_000073.1 Bcat2    BIND  PubMed Myc interacts with the Bcat2 (Eca40) promoter. 
    NP_034979.2 AF053338.1 Cad    BIND  PubMed Myc interacts with the Cad promoter. 
    NP_034979.2 AF124227.1 Cav1    BIND  PubMed Myc interacts with the Cav1 promoter. 
    NP_034979.2 AC112701.6 Ccnb1    BIND  PubMed Myc interacts with the Ccnb1 promoter. 
    NP_034979.2 AF182716.1 Ccnd1    BIND  PubMed Myc interacts with the Ccnd1 promoter. 
    NP_034979.2 NC_000072.1 Ccnd2    BIND  PubMed Myc interacts with the Ccnd2 promoter. 
    NP_034979.2 NC_000075.1 Cdc25a    BIND  PubMed Myc interacts with the Cdc25a promoter. 
    NP_034979.2 AF223390.1 Cdk4    BIND  PubMed Myc interacts with the Cdk4 promoter. 
    NP_034979.2 U24171.1 Cdkn1a    BIND  PubMed Myc interacts with the Cdkn1a promoter. 
    NP_034979.2 U51681.1 Cdkn1b    BIND  PubMed Myc interacts with the Cdkn1b (p27) promoter. 
    NP_034979.2 AF120108.1 Cdkn2a    BIND  PubMed Myc interacts with the Cdkn2a promoter. 
    NP_034979.2 NP_034007.1 Cdkn2a    BIND  PubMed ARF interacts with c-Myc. 
    NP_034979.2 U66084.1 Cdkn2b    BIND  PubMed Myc interacts with the Cdkn2b promoter. 
    NP_034979.2 AC111011.6 Ddx18    BIND  PubMed Myc interacts with the Ddx18 promoter. 
    NP_034979.2 NP_001003961.1 Dnmt3b    BIND  PubMed Myc interacts with Dmnt3b. This interaction was modeled on a demonstrated interaction between Myc from an unspecified species and mouse Dmnt3b. 
    NP_034979.2 NC_000083.1 Dnph1    BIND  PubMed Myc interacts with the BC048355 (Rcl) promoter. 
    NP_034979.2 AC123869.4 Eif2s1    BIND  PubMed Myc interacts with the Eif2s1 (Eif2a) promoter. 
    NP_034979.2 AF079156.1 Eif4e    BIND  PubMed Myc interacts with the Eif4e promoter. 
    NP_034979.2 AF055577.1 Emp1    BIND  PubMed Myc interacts with the Emp1 (TMP) gene. 
    NP_034979.2 X66236.1 Erbb2    BIND  PubMed Myc interacts with the Neu promoter. 
    NP_034979.2 M60170.1 Fth1    BIND  PubMed Myc interacts with the Fth1 promoter. 
    NP_034979.2 U00937.1 Gadd45a    BIND  PubMed Myc interacts with the Gadd45a gene. 
    NP_034979.2 M35021.1 Hspa1b    BIND  PubMed Myc interacts with the Hspa1b (Hsp70.1) gene. 
    NP_034979.2 U72760.1 Irf9    BIND  PubMed Myc interacts with the Isgf3g promoter. 
    NP_034979.2 X03753.1 Ldha    BIND  PubMed Myc interacts with the Ldh1 (LDH-A) promoter. 
    NP_034979.2 AAB35748.1 Max    BIND  PubMed dMax interacts with c-Myc. This interaction was modeled on a demonstrated interaction between mouse dMax and human c-Myc. 
    NP_034979.2 NP_032584.1 Max    BIND  PubMed Max interacts with c-Myc to form a heterodimer. This interaction was modeled on a demonstrated interaction between Max from an unspecified species and mouse c-Myc. 
    NP_034979.2 NP_032584.1 Max    BIND  PubMed Max interacts with c-myc. This interaction was modeled on a demonstrated interaction between Max from human and c-myc from mouse. 
    NP_034979.2 X07699.1 Ncl    BIND  PubMed Myc interacts with the Ncl (Nucl) gene. 
    NP_034979.2 AL772409.4 Npm1    BIND  PubMed Myc interacts with the Npm1 (B23) promoter. 
    NP_034979.2 J03733.1 Odc1    BIND  PubMed Myc interacts with the Odc1 gene. 
    NP_034979.2 NC_000084.1 Pdgfrb    BIND  PubMed Myc interacts with the Pdgfr promoter. 
    NP_034979.2 AC122268.5 Polr3d    BIND  PubMed Myc interacts with the Polr3d (BN51T) promoter. 
    NP_034979.2 NC_000067.1 Ptma    BIND  PubMed Myc interacts with the Ptma gene. 
    NP_034979.2 NP_035580.1 Sp3    BIND  PubMed Myc interacts with Sp3. 
    NP_034979.2 AF121949.1 Tert    BIND  PubMed Myc interacts with the Tert gene. 
    NP_034979.2 M62449.1 Thbs1    BIND  PubMed Myc interacts with the Thbs1 gene. 
    NP_034979.2 NC_000077.1 Trp53    BIND  PubMed Myc interacts with the Trp53 (p53) promoter. 
    BioGRID:201635 BioGRID:198143 Apc    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:201635 BioGRID:198318 Bcl2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:201635 BioGRID:198660 Cdr2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:201635 BioGRID:198887 Crk    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:201635 BioGRID:208493 Huwe1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:201635 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:201635 BioGRID:111226 PFDN5    BioGRID  PubMed Two-hybrid 
    BioGRID:201635 BioGRID:111089 PRDX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:201635 BioGRID:112482 SMARCB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:201635 BioGRID:203336 Smarca4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:201635 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:201635 BioGRID:213691 Trim32    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:201635 BioGRID:204346 Tsix    BioGRID  PubMed Affinity Capture-RNA 
    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
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    • Acute myeloid leukemia, conserved biosystem (from KEGG)
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    • Apoptosis, organism-specific biosystem (from WikiPathways)
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    • Bladder cancer, organism-specific biosystem (from KEGG)
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    • Bladder cancer, conserved biosystem (from KEGG)
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    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell cycle, organism-specific biosystem (from KEGG)
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    • Cell cycle, conserved biosystem (from KEGG)
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    • Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
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      Cell cycle signaling pathway
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
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    • Colorectal cancer, organism-specific biosystem (from KEGG)
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      Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
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      Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
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    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
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    • ErbB signaling pathway, conserved biosystem (from KEGG)
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    • FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
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    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • HTLV-I infection, organism-specific biosystem (from KEGG)
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    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
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    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
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    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
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    • Proteoglycans in cancer, conserved biosystem (from KEGG)
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    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by NOTCH1 HD Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD Domain Mutants in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
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    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
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      Transcriptional misregulation in cancer, organism-specific biosystem
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      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • p38 MAPK Signaling Pathway (BioCarta), organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway (BioCarta), organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    E-box binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    DNA-dependent transcription, initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Wnt receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    apoptotic DNA fragmentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    canonical Wnt receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    canonical Wnt receptor signaling pathway involved in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    		  
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
    		  
    chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    detection of mechanical stimulus involved in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    inner mitochondrial membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lactic acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    middle ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of B cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    positive regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of glycolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of metanephric cap mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of transcription, DNA-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    pyruvate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of transcription, DNA-dependent IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		  
    response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    response to alkaloid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    response to radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription, DNA-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    transformation of host cell by virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    myc proto-oncogene protein
    Names
    myc proto-oncogene protein
    c-myc proto-oncogene
    transcription factor p64

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177352.1 → NP_001170823.1  myc proto-oncogene protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (a, also known as c-Myc 1) is derived from a non-AUG (CUG) start codon, while a shorter isoform (b, also known as c-Myc 2) is derived from a downstream AUG start codon. The shorter isoform (b) is represented in this RefSeq, and is 15 aa shorter, compared to isoform a. Both variants 1 and 2 can encode isoform b.
      Source sequence(s)
      BB858498, BC138931, BE456204, BE853266
      Consensus CDS
      CCDS49615.1
      UniProtKB/TrEMBL
      B2RSN1
      UniProtKB/Swiss-Prot
      P01108
      Related
      ENSMUSP00000123821, OTTMUSP00000048371, ENSMUST00000161976, OTTMUST00000088692
      Conserved Domains (3) summary
      cd00083
      Location:352 – 411
      Blast Score: 150
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:1 – 202
      Blast Score: 625
      Myc_N; Myc amino-terminal region
      pfam02344
      Location:408 – 439
      Blast Score: 122
      Myc-LZ; Myc leucine zipper domain

    2. NM_001177353.1 → NP_001170824.1  myc proto-oncogene protein isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This variant encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (c) is derived from a non-AUG (CUG) start codon, while a shorter isoform (b, also known as c-Myc 2) is derived from a downstream AUG start codon. The longer isoform (c) is represented in this RefSeq, and is 1 aa shorter, compared to isoform a.
      Source sequence(s)
      AK133952, BE456204, BE853266
      Consensus CDS
      CCDS49614.1
      UniProtKB/Swiss-Prot
      P01108
      Conserved Domains (3) summary
      cd00083
      Location:366 – 425
      Blast Score: 152
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:15 – 216
      Blast Score: 628
      Myc_N; Myc amino-terminal region
      pfam02344
      Location:422 – 453
      Blast Score: 125
      Myc-LZ; Myc leucine zipper domain

    3. NM_001177354.1 → NP_001170825.1  myc proto-oncogene protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This variant encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (c) is derived from a non-AUG (CUG) start codon, while a shorter isoform (b, also known as c-Myc 2) is derived from a downstream AUG start codon. The shorter isoform (b) is represented in this RefSeq, and is 15 aa shorter, compared to isoform a. Both variants 1 and 2 can encode isoform b.
      Source sequence(s)
      AK133952, BE456204, BE853266
      Consensus CDS
      CCDS49615.1
      UniProtKB/Swiss-Prot
      P01108
      Related
      ENSMUSP00000124758, OTTMUSP00000048374, ENSMUST00000159327, OTTMUST00000088695
      Conserved Domains (3) summary
      cd00083
      Location:352 – 411
      Blast Score: 150
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:1 – 202
      Blast Score: 625
      Myc_N; Myc amino-terminal region
      pfam02344
      Location:408 – 439
      Blast Score: 122
      Myc-LZ; Myc leucine zipper domain

    4. NM_010849.4 → NP_034979.3  myc proto-oncogene protein isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (a, also known as c-Myc 1) is derived from a non-AUG (CUG) start codon, while a shorter isoform (b, also known as c-Myc 2) is derived from a downstream AUG start codon. The longer isoform (a) is represented in this RefSeq.
      Source sequence(s)
      BB858498, BC138931, BE456204, BE853266
      Consensus CDS
      CCDS27504.1
      UniProtKB/TrEMBL
      B2RSN1
      Related
      ENSMUSP00000022971, OTTMUSP00000048877, ENSMUST00000022971, OTTMUST00000089437
      Conserved Domains (3) summary
      cd00083
      Location:367 – 426
      Blast Score: 152
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:16 – 217
      Blast Score: 628
      Myc_N; Myc amino-terminal region
      pfam02344
      Location:423 – 454
      Blast Score: 124
      Myc-LZ; Myc leucine zipper domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p1 C57BL/6J

      Range
      61985341..61990361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000037.1 Alternate Mm_Celera

      Range
      63490745..63495748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01122709.1 None
    genomic AAHY01122710.1 (28081..29953) None
    genomic AC134611.4 (152619..157594) None
    genomic AF519452.1 AAN03877.1
    genomic AY294976.1 AAQ57173.1 BALB/c
    genomic CH466545.1 EDL29340.1 mixed
    genomic K00683.1 None
    genomic L00038.1 AAB59728.1 BALB/c
    genomic L00039.1 AAB59728.1 BALB/c
    genomic X05213.1 CAA28840.1
    genomic Z18894.1 None
    genomic Z69808.1 None NMRI
    genomic Z69825.1 None NMRI
    genomic Z69827.1 None NMRI
    mRNA AF076523.1 AAC26879.1
    mRNA AK087961.1 BAC40060.1 NOD
    mRNA AK133952.1 BAE21948.1 C57BL/6J
    mRNA AK145084.1 BAE26228.1
    mRNA BB858498.1 None C57BL/6
    mRNA BC006728.1 AAH06728.2 FVB/N
    mRNA BC138931.1 AAI38932.1
    mRNA BC138932.1 AAI38933.1
    mRNA BE456204.1 None C57BL/6J
    mRNA BE849613.1 None
    mRNA BE853266.1 None
    mRNA X01023.1 CAA25508.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01108.1 GenPept UniProtKB/Swiss-Prot:P01108

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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