Mybl2 myeloblastosis oncogene-like 2 [Mus musculus] - Gene

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Summary

Official Symbol: Mybl2provided by MGI
Official Full Name: myeloblastosis oncogene-like 2provided by MGI
Primary source: MGI:101785
Locus tag: RP23-335N12.7
See related: Ensembl:ENSMUSG00000017861; Vega:OTTMUSG00000001166
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmyb; B-Myb

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Genomic context

Location :: 2 H2; 2 93.0 cM

Sequence :: Chromosome: 2; NC_000068.7 (163054635..163084687)

See Mybl2 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression.
Title: Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
Lin-9 and B-Myb were both required for transcription of G(2)/M genes such as Cyclin B1 and Survivin.
Title: A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells.
proliferation-inhibiting A(2B)AR is itself an inducible receptor regulated by B-Myb.
Title: B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells.
The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction.
Title: Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex.
The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
Title: The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
B-Myb has a role in regulation of c-Myc expression by cytosolic phospholipase A2
Title: B-Myb-dependent regulation of c-Myc expression by cytosolic phospholipase A2.
Results describe the characterization of a corepressor site (downstream repression site (DRS)) required for transcriptional regulation of the B-myb (MybL2 gene) promoter.
Title: A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107 x E2F and p130 x E2F complexes.
B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain.
Title: B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain.
B-Myb represses SMC elastin gene expression and cyclin A plays a role in the developmental regulation of elastin gene expression in the aorta
Title: B-Myb represses elastin gene expression in aortic smooth muscle cells.
Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1
Title: Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1.

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (3) 1 citation
Targeted (knock-out) (2) 1 citation
Gene trapped (1)

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000068.1	NP_031917.1	E2f1	BIND	PubMed	E2f1 (E2F-1) interacts with the Mybl2 (b-myb) promoter.
NC_000068.1	NP_808401.1	E2f2	BIND	PubMed	E2f2 (E2F-2) interacts with the Mybl2 (b-myb) promoter.
NC_000068.1	XP_127250.4	E2f3	BIND	PubMed	E2f3 (E2F-3) interacts with Mybl2 (b-myb) promoter.
NC_000068.1	NP_683754.1	E2f4	BIND	PubMed	E2F-4 interacts with B-Myb promoter.
NC_000068.1	NP_031918.2	E2f5	BIND	PubMed	E2f5 (E2F-5) interacts with the Mybl2 (b-myb) promoter.
BioGRID:201633	BioGRID:236949	AW146020	BioGRID	PubMed	Two-hybrid
BioGRID:201633	BioGRID:114417	CCNA1	BioGRID	PubMed	Biochemical Activity
BioGRID:201633	BioGRID:107067	CCND1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:201633	BioGRID:107452	CDK2	BioGRID	PubMed	Biochemical Activity
BioGRID:201633	BioGRID:198548	Ccnd1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201633	BioGRID:204701	Ikzf2	BioGRID	PubMed	Two-hybrid
BioGRID:201633	BioGRID:219895	Tfcp2l1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
spindle assembly involved in mitosis	IDA Inferred from Direct Assay more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Myb complex	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: myb-related protein B

Names: myb-related protein B; myb-like protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008652.2 → NP_032678.1 myb-related protein B

Status: PROVISIONAL

Source sequence(s)

AK028497

Consensus CDS

CCDS17006.1

UniProtKB/TrEMBL

A2A5P2

UniProtKB/Swiss-Prot

P48972

Related

ENSMUSP00000018005, OTTMUSP00000001107, ENSMUST00000018005, OTTMUST00000002262

Conserved Domains (3) summary

cd00167
Location:85 – 129
Blast Score: 161

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

smart00717
Location:83 – 131
Blast Score: 182

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:454 – 598
Blast Score: 504

Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38 C57BL/6J

Range

163054635..163084687

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

169001317..169031320

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL591584.14	CAM21348.1
		CAM21349.1
genomic	CH466551.1	EDL06316.1	mixed
genomic	X73028.1	CAA51511.1	C57BL/6
mRNA	AK028497.1	BAC25979.1	C57BL/6J
mRNA	AK184787.1	None
mRNA	AK199400.1	None
mRNA	AK215181.1	None
mRNA	BC050842.1	AAH50842.1
mRNA	BC117945.1	None
mRNA	X70472.1	CAA49898.1