These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_028016.1 RefSeqGene
- Range
- 5001..66734
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001130823.1 → NP_001124295.1 DNA (cytosine-5)-methyltransferase 1 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
- Source sequence(s)
-
BC092517, BC126227, DA653750, X63692
- Consensus CDS
-
CCDS45958.1
- UniProtKB/Swiss-Prot
-
P26358
- Related
- ENSP00000352516, ENST00000359526
- Conserved Domains (6) summary
-
- cd04711
Location:981 – 1117
Blast Score: 666
- BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- cd04760
Location:770 – 893
Blast Score: 550
- BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- pfam06464
Location:16 – 105
Blast Score: 252
- DMAP_binding; DMAP1-binding Domain
- pfam02008
Location:662 – 707
Blast Score: 209
- zf-CXXC; CXXC zinc finger domain
- pfam12047
Location:415 – 550
Blast Score: 413
- DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
- cl16911
Location:1155 – 1384
Blast Score: 306
- AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
-
NM_001379.2 → NP_001370.1 DNA (cytosine-5)-methyltransferase 1 isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
- Source sequence(s)
-
BC092517, BC126227, DA653750, X63692
- Consensus CDS
-
CCDS12228.1
- UniProtKB/Swiss-Prot
-
P26358
- Related
- ENSP00000345739, ENST00000340748
- Conserved Domains (6) summary
-
- cd04711
Location:965 – 1101
Blast Score: 666
- BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- cd04760
Location:754 – 877
Blast Score: 550
- BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- pfam06464
Location:16 – 105
Blast Score: 253
- DMAP_binding; DMAP1-binding Domain
- pfam02008
Location:646 – 691
Blast Score: 209
- zf-CXXC; CXXC zinc finger domain
- pfam12047
Location:399 – 534
Blast Score: 412
- DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
- cl16911
Location:1139 – 1368
Blast Score: 305
- AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000019.9 Reference GRCh37.p5 Primary Assembly
- Range
- 10244022..10305755, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000151.1 Alternate HuRef
- Range
- 9824670..9886268, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)