DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: DYNC1LI2provided by HGNC
Official Full Name: dynein, cytoplasmic 1, light intermediate chain 2provided by HGNC
Primary source: HGNC:2966
See related: Ensembl:ENSG00000135720; HPRD:09923; MIM:611406; Vega:OTTHUMG00000137523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LIC2; DNCLI2
Summary: Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]

Genomic context

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Location :: 16q22.1

Sequence :: Chromosome: 16; NC_000016.9 (66754799..66785525, complement)

See DYNC1LI2 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway.
Title: Recruitment of dynein to late endosomes and lysosomes through light intermediate chains.
FIP3 was identified as the first membrane-associated interacting-partner for DLIC-2.
Title: Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
O43237	Q08495	DMTN	HPRD	PubMed
BioGRID:108120	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:108120	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:108353	DMTN	BioGRID	PubMed	Two-hybrid
BioGRID:108120	BioGRID:108117	DYNC1H1	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:108120	BioGRID:108119	DYNC1I2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:119327	DYNC1LI1	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:108120	BioGRID:114206	DYNLL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:123715	DYNLRB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:112853	DYNLT1	BioGRID	PubMed	Co-fractionation
BioGRID:108120	BioGRID:112850	DYNLT3	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:108120	BioGRID:199254	Dync1h1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:199256	Dync1i2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:207994	Dynll1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:118148	EIF3K	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:108120	BioGRID:108605	FLNA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:115671	GNB2L1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:109422	HNRNPA2B1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:110899	NMT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:127687	PRUNE2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:112142	RPS23	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:112145	RPS26	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:112107	RPS5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:110115	RPSA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108120	BioGRID:110959	YBX1	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Salmonella infection, organism-specific biosystem (from KEGG)
Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Salmonella infection, conserved biosystem (from KEGG)
Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...

General gene information

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Markers

NoName (e-PCR)
- UniSTS:56070

RH69477 (e-PCR)
- UniSTS:42850

SHGC-83995 (e-PCR)
- UniSTS:104626

RH79037 (e-PCR)
- UniSTS:6114

SHGC-61131 (e-PCR)
- UniSTS:75494

SHGC-61068 (e-PCR)
- UniSTS:30461

Homology

Homologs of the DYNC1LI2 gene: The DYNC1LI2 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS Traceable Author Statement more info
centrosome localization	IEA Inferred from Electronic Annotation more info
microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info
cytoplasmic dynein complex	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytoplasmic dynein 1 light intermediate chain 2

Names: cytoplasmic dynein 1 light intermediate chain 2; LIC-2; LIC53/55; dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic, light intermediate polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006141.2 → NP_006132.1 cytoplasmic dynein 1 light intermediate chain 2

Status: VALIDATED

Source sequence(s)

AF035812, AL708642, BC022934, BM805417, BX648863

Consensus CDS

CCDS10818.1

UniProtKB/Swiss-Prot

O43237

UniProtKB/TrEMBL

Q63HJ8

Related

ENSP00000258198, OTTHUMP00000174820, ENST00000258198, OTTHUMT00000268846

Conserved Domains (2) summary

pfam05783
Location:8 – 488
Blast Score: 2233

DLIC; Dynein light intermediate chain (DLIC)

cl09099
Location:218 – 294
Blast Score: 92

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p10 Primary Assembly

Range

66754799..66785525, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

52629870..52660679, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018927.1 Alternate CHM1_1.0

Range

67761022..67791743, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01025413.1 (23977..37974)	None
genomic	ABBA01025414.1	None
genomic	ABBA01025415.1	None
genomic	AC018557.9 (159552..180709)	None
genomic	AC044802.6 (11396..20964)	None
genomic	AMYH01007742.1 (23967..54688)	None
genomic	CH471092.1	EAW83039.1
		EAW83040.1
mRNA	AF035812.1	AAB88513.1
mRNA	AK024863.1	None
mRNA	AK095237.1	None
mRNA	AK291766.1	BAF84455.1
mRNA	AK295049.1	BAG58099.1
mRNA	AK303031.1	BAG64156.1
mRNA	AK304233.1	BAG65102.1
mRNA	AL708642.1	None
mRNA	BC010928.1	None
mRNA	BC022934.1	None
mRNA	BC025959.1	AAH25959.1
mRNA	BC036633.2	None
mRNA	BC069056.1	None
mRNA	BM805417.1	None
mRNA	BX648863.1	CAH56157.1