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daf-14 Smad-related protein daf-14 [ Caenorhabditis elegans ]

Gene ID: 177908, updated on 23-Nov-2023

Summary

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Gene symbol
daf-14
Gene description
Smad-related protein daf-14
Primary source
WormBase:WBGene00000910
Locus tag
CELE_F01G10.8
See related
AllianceGenome:WB:WBGene00000910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of dauer larval development; and oviposition. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including anal sphincter muscle; excretory duct cell; intestine; nerve ring; and phasmid sheath cell. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10250627..10255852)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transketolase-like pyrimidine-binding domain-containing protein Neighboring gene BPI2 domain-containing protein Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode Specific Peptide family, group D

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. Golden JW, et al. Dev Biol, 1984 Apr. PMID 6706004
  2. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Schackwitz WS, et al. Neuron, 1996 Oct. PMID 8893028
  3. Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans. Park D, et al. Development, 2010 Feb. PMID 20081192, Free PMC Article
  4. A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans. Raizen DM, et al. Genetics, 2006 May. PMID 16547093, Free PMC Article
  5. M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape. Muriel JM, et al. Dev Biol, 2003 Aug 15. PMID 12921736

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pigment accumulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pigment accumulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organismal process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Smad-related protein daf-14
NP_001255475.1
  • Confirmed by transcript evidence
NP_001255476.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10250627..10255852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268546.3 → NP_001255475.1  Smad-related protein daf-14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255475.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F5GUE5, G5EEP2
    Conserved Domains (1) summary
    smart00524
    Location:133 → 308
    DWB; Domain B in dwarfin family proteins

  2. NM_001268547.2 → NP_001255476.1  Smad-related protein daf-14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255476.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEP2
    Conserved Domains (1) summary
    smart00524
    Location:89 → 264
    DWB; Domain B in dwarfin family proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F5GUE5.1

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