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Mtf2 metal response element binding transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 17765, updated on 8-May-2016
Official Symbol
Mtf2provided by MGI
Official Full Name
metal response element binding transcription factor 2provided by MGI
Primary source
MGI:MGI:105050
See related
Ensembl:ENSMUSG00000029267 Vega:OTTMUSG00000021413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M96; Pcl2; C76717; AA537621; 9230112N11Rik
Orthologs
Location:
5; 5 F
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (108065669..108109219)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108494761..108538023)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34001 Neighboring gene predicted gene, 42150 Neighboring gene ribosomal protein S19, pseudogene 8 Neighboring gene transmembrane emp24 protein transport domain containing 5 Neighboring gene coiled-coil domain containing 18 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC116639

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
metal-response element-binding transcription factor 2
Names
mPCl2
metal regulatory transcription factor 2
metal response element DNA-binding protein M96
metal-response element DNA-binding protein M96
polycomb-like protein 2
ziRF1
zinc-regulated factor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253877.1NP_001240806.1  metal-response element-binding transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001240806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK031409, AK032819, BC092237, CJ311871
    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  2. NM_001253878.1NP_001240807.1  metal-response element-binding transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001240807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, which results in a downstream AUG start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK139685, BC092237, CJ311871
    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  3. NM_001253879.1NP_001240808.1  metal-response element-binding transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001240808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK030752, AK031409, BC092237, CJ311871
    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  4. NM_001253880.1NP_001240809.1  metal-response element-binding transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001240809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK031409, AK137539, BC092237, BC100340, CJ311871
    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  5. NM_013827.3NP_038855.2  metal-response element-binding transcription factor 2 isoform 1

    See identical proteins and their annotated locations for NP_038855.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK031409, AK137539, BC092237, CJ311871
    Consensus CDS
    CCDS39201.1
    UniProtKB/Swiss-Prot
    Q02395
    Related
    ENSMUSP00000080278, OTTMUSP00000023775, ENSMUST00000081567, OTTMUST00000050749
    Conserved Domains (4) summary
    smart00333
    Location:4595
    TUDOR; Tudor domain
    pfam14061
    Location:544592
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:104156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)

RNA

  1. NR_045608.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an additional exon and also lacks an internal segment in the 5' region, compared to variant 1. This transcript is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK031409, AK032798, AK137539, BC092237, CJ311871

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    108065669..108109219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249417.1XP_011247719.1  

    Conserved Domains (3) summary
    cd04508
    Location:60104
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15578
    Location:115167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cl22851
    Location:214265
    PHD_SF; PHD finger superfamily
  2. XM_011249412.1XP_011247714.1  

    See identical proteins and their annotated locations for XP_011247714.1

    Conserved Domains (4) summary
    smart00333
    Location:56106
    TUDOR; Tudor domain
    pfam14061
    Location:555603
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:115167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:214265
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  3. XM_006534808.2XP_006534871.1  

    See identical proteins and their annotated locations for XP_006534871.1

    Conserved Domains (4) summary
    smart00333
    Location:56106
    TUDOR; Tudor domain
    pfam14061
    Location:555603
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:115167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:214265
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  4. XM_011249415.1XP_011247717.1  

    See identical proteins and their annotated locations for XP_011247717.1

    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  5. XM_006534811.2XP_006534874.1  

    See identical proteins and their annotated locations for XP_006534874.1

    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  6. XM_011249416.1XP_011247718.1  

    See identical proteins and their annotated locations for XP_011247718.1

    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  7. XM_011249414.1XP_011247716.1  

    See identical proteins and their annotated locations for XP_011247716.1

    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
  8. XM_011249413.1XP_011247715.1  

    See identical proteins and their annotated locations for XP_011247715.1

    UniProtKB/Swiss-Prot
    Q02395
    Conserved Domains (3) summary
    pfam14061
    Location:442490
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)

RNA

  1. XR_389261.2 RNA Sequence

  2. XR_389262.2 RNA Sequence

    Related
    ENSMUST00000131264

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    105183366..105227621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)