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pycr-4 Putative pyrroline-5-carboxylate reductase [ Caenorhabditis elegans ]

Gene ID: 177519, updated on 23-Nov-2023

Summary

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Gene symbol
pycr-4
Gene description
Putative pyrroline-5-carboxylate reductase
Primary source
WormBase:WBGene00018904
Locus tag
CELE_F55G1.9
See related
AllianceGenome:WB:WBGene00018904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Is expressed in hypodermis and intestinal cell. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (7476163..7477297, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase plk-3 Neighboring gene RING-CH-type domain-containing protein Neighboring gene SLC (SoLute Carrier) homolog Neighboring gene Kinetochore-associated protein rod-1 Neighboring gene Histone H2A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
  2. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article
  3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrroline-5-carboxylate reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative pyrroline-5-carboxylate reductase
NP_501199.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7476163..7477297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068798.6 → NP_501199.1  Putative pyrroline-5-carboxylate reductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501199.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20848
    Conserved Domains (3) summary
    PRK11880
    Location:18 → 296
    PRK11880; pyrroline-5-carboxylate reductase; Reviewed
    pfam03807
    Location:19 → 112
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    pfam14748
    Location:181 → 292
    P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20848.1

Gene LinkOut

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