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spd-3 Spindle defective protein 3 [ Caenorhabditis elegans ]

Gene ID: 177438, updated on 20-Oct-2023

Summary

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Gene symbol
spd-3
Gene description
Spindle defective protein 3
Primary source
WormBase:WBGene00004954
Locus tag
CELE_H34C03.1
See related
AllianceGenome:WB:WBGene00004954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including homologous chromosome segregation; microtubule cytoskeleton organization; and vulval development. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (6762716..6765200)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis. Labrador L, et al. PLoS Genet, 2013 May. PMID 23671424, Free PMC Article
  2. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans. O'Connell KF, et al. Genetics, 1998 Jul. PMID 9649522, Free PMC Article
  3. SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria. Dinkelmann MV, et al. Genetics, 2007 Nov. PMID 17947426, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events.
    Title: Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events.
  2. SPD-3 is required for homology search at the start of meiosis
    Title: Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in chromosome localization to nuclear envelope involved in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Spindle defective protein 3
NP_501036.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6762716..6765200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068635.7 → NP_501036.1  Spindle defective protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501036.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TYY7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TYY7.1

Gene LinkOut

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