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pes-1 Forkhead box protein pes-1 [ Caenorhabditis elegans ]

Gene ID: 177267, updated on 23-Nov-2023

Summary

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Gene symbol
pes-1
Gene description
Forkhead box protein pes-1
Primary source
WormBase:WBGene00003976
Locus tag
CELE_T28H11.4
See related
AllianceGenome:WB:WBGene00003976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryo development and nematode larval development. Predicted to be located in nucleus. Is expressed in several structures, including ABalpa; ABalpaa; body wall muscle cell from D lineage; neurons; and somatic gonad precursor. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (5002748..5005486)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors. Hope IA. Development, 1994 Mar. PMID 8162851
  2. gon-2, a gene required for gonadogenesis in Caenorhabditis elegans. Sun AY, et al. Genetics, 1997 Nov. PMID 9383054, Free PMC Article
  3. A fork head/HNF-3 homolog expressed in the pharynx and intestine of the Caenorhabditis elegans embryo. Azzaria M, et al. Dev Biol, 1996 Sep 15. PMID 8812130
  4. Promoter trapping identifies real genes in C. elegans. Hope IA, et al. Mol Gen Genet, 1998 Nov. PMID 9862485
  5. Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues. Molin L, et al. Development, 2000 Nov. PMID 11044397

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Forkhead box protein pes-1
NP_001023406.1
  • Confirmed by transcript evidence
NP_001380128.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5002748..5005486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028235.3 → NP_001023406.1  Forkhead box protein pes-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023406.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGC9, Q7JMT8
    Conserved Domains (2) summary
    cd00059
    Location:93 → 168
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    TIGR00601
    Location:203 → 240
    rad23; UV excision repair protein Rad23

  2. NM_001392306.1 → NP_001380128.1  Forkhead box protein pes-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    TIGR00601
    Location:167 → 204
    rad23; UV excision repair protein Rad23
    pfam00250
    Location:57 → 132
    Forkhead; Forkhead domain
Nucleotide Protein
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