wapl-1 WAPL domain-containing protein;Wings apart-like protein homolog 1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Gene symbol: wapl-1
Gene description: WAPL domain-containing protein;Wings apart-like protein homolog 1
Primary source: WormBase:WBGene00019953
Locus tag: CELE_R08C7.10
See related: AllianceGenome:WB:WBGene00019953
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in negative regulation of cohesin loading and positive regulation of double-strand break repair via homologous recombination. Located in germ cell nucleus. Orthologous to human WAPL (WAPL cohesin release factor). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See wapl-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 13

Sequence:: Chromosome: IV; NC_003282.8 (4442362..4445740, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1.
Title: The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1.
Data show that condensin I binds to WAPL-1 and counteracts WAPL-1-dependent cohesin removal.
Title: Condensin I protects meiotic cohesin from WAPL-1 mediated removal.
WAPL-1-sensitive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 complexes provide stable cohesion.
Title: Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

R08C7.10 (e-PCR)
- UniSTS:312103

R08C7.3 (e-PCR)
- UniSTS:321020

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP-dependent protein-DNA unloader activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cohesin unloader activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: WAPL domain-containing protein;Wings apart-like protein homolog 1

NP_001360111.1

Confirmed by transcript evidence

NP_001368333.1

Confirmed by transcript evidence

NP_001368334.1

Confirmed by transcript evidence

NP_500566.1

Confirmed by transcript evidence

NP_500567.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4442362..4445740 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068165.6 → NP_500566.1 Wings apart-like protein homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500566.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0H5

Conserved Domains (1) summary

pfam07814
Location:217 → 561

WAPL; Wings apart-like protein regulation of heterochromatin
NM_068166.8 → NP_500567.1 WAPL domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500567.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21843

Conserved Domains (1) summary

pfam07814
Location:215 → 559

WAPL; Wings apart-like protein regulation of heterochromatin
NM_001372798.2 → NP_001360111.1 WAPL domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0H6

Conserved Domains (1) summary

pfam07814
Location:215 → 559

WAPL; Wings apart-like protein regulation of heterochromatin
NM_001380189.1 → NP_001368334.1 WAPL domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PCH6

Conserved Domains (1) summary

cl00304
Location:18 → 95

TP_methylase; S-AdoMet-dependent tetrapyrrole methylases
NM_001380190.1 → NP_001368333.1 WAPL domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PC40

Conserved Domains (1) summary

pfam07814
Location:217 → 561

WAPL; Wings apart-like protein regulation of heterochromatin