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M57.2 Geranylgeranyl transferase type-2 subunit alpha;Protein geranylgeranyltransferase type II [ Caenorhabditis elegans ]

Gene ID: 177113, updated on 11-Apr-2024

Summary

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Gene symbol
M57.2
Gene description
Geranylgeranyl transferase type-2 subunit alpha;Protein geranylgeranyltransferase type II
Primary source
WormBase:WBGene00019778
Locus tag
CELE_M57.2
See related
AllianceGenome:WB:WBGene00019778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein prenyltransferase activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in protein geranylgeranylation. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytoplasm. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (3527354..3532473)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Amidohydrolase-related domain-containing protein;Protein unc-33 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene SPK domain-containing protein Neighboring gene SPK domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Lackner MR, et al. Cancer Cell, 2005 Apr. PMID 15837622
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of Rab geranylgeranyl transferase by farnesyl transferase inhibitors or RNA interference, induced apoptotis in germ line cells.
    Title: Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to Rab geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Rab geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein prenylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Geranylgeranyl transferase type-2 subunit alpha;Protein geranylgeranyltransferase type II
NP_001368209.1
  • Confirmed by transcript evidence
NP_500367.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3527354..3532473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067966.5 → NP_500367.1  Geranylgeranyl transferase type-2 subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500367.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TYY0
    Conserved Domains (6) summary
    COG4886
    Location:405 → 550
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    COG5536
    Location:37 → 264
    BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]
    sd00031
    Location:501 → 522
    LRR_1; leucine-rich repeat [structural motif]
    sd00006
    Location:123 → 153
    TPR; TPR repeat [structural motif]
    pfam01239
    Location:179 → 206
    PPTA; Protein prenyltransferase alpha subunit repeat
    pfam12799
    Location:499 → 539
    LRR_4; Leucine Rich repeats (2 copies)

  2. NM_001380149.1 → NP_001368209.1  Protein geranylgeranyltransferase type II [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB59
Nucleotide Protein
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