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    AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]

    Gene ID: 177, updated on 20-May-2012
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    Summary

    Official Symbol
    AGERprovided by HGNC
    Official Full Name
    advanced glycosylation end product-specific receptorprovided by HGNC
    Primary source
    HGNC:320
    Locus tag
    DAMA-358M23.4
    See related
    Ensembl:ENSG00000204305; HPRD:02568; MIM:600214; Vega:OTTHUMG00000031120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAGE; MGC22357
    Summary
    The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (32148745..32152099, complement)
    See AGER in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene PPT2-EGFL8 readthrough Neighboring gene EGF-like-domain, multiple 8 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) Neighboring gene ring finger protein 5, E3 ubiquitin protein ligase Neighboring gene pre-B-cell leukemia homeobox 2 Neighboring gene G-protein signaling modulator 3 Neighboring gene notch 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The receptor for advanced glycation endproducts and its ligands in patients with myasthenia gravis. Moser B, et al. Biochem Biophys Res Commun, 2012 Mar 30. PMID 22405771.
    2. Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma. Korwar AM, et al. Biochem Biophys Res Commun, 2012 Mar 16. PMID 22366088.
    3. Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis. Narvaez-Rivera RM, et al. BMC Infect Dis, 2012 Jan 20. PMID 22264245.
    4. Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ramasamy R, et al. Ann N Y Acad Sci, 2011 Dec. PMID 22211895.
    5. Targeting receptor for advanced glycation end products (RAGE) expression induces apoptosis and inhibits prostate tumor growth. Elangovan I, et al. Biochem Biophys Res Commun, 2012 Jan 27. PMID 22206663.

    See all (384) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The association of elevated sRAGE with a fatal outcome suggests that it may have an independent causal effect in community-acquired pneumonia.
      Title: Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis.
    2. these data suggest a role for the RAGE pathway in the pathophysiology of myasthenia gravis.
      Title: The receptor for advanced glycation endproducts and its ligands in patients with myasthenia gravis.
    3. RAGE expression and its downstream signaling proteins NADPH oxidase and NF-kB in HER2/neu negative invasive ductal carcinoma were studied.
      Title: Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma.
    4. RAGE polymorphism is associated with aspergillosis in stem cell transplant recipients.
      Title: Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients.
    5. AGER 82S allele showed a protective effect on CAD severity in the presence of T2DM in Chinese Han population.
      Title: Association of AGER gene G82S polymorphism with the severity of coronary artery disease in Chinese Han population.
    6. a novel mechanism through which an extracellular signal initiated by RAGE ligands regulates RAGE signaling in a manner requiring mDia1.
      Title: Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1.
    7. Suggest that elevated plasma EN-RAGE and decreased sRAGE level could play a crucial role in systemic inflammation and carotid atherosclerosis in peritoneal dialysis patients.
      Title: Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis.
    8. Both HMGB1 and RAGE participate in the inflammatory process of asthmatic airway.
      Title: [Changes of HMGB1 and RAGE in induced sputum from patients with bronchial asthma].
    9. Suggest that sRAGE may have a protective effect against subclinical atherosclerosis by preventing inflammatory responses in HIV-infected patients receiving combined antiretroviral therapy.
      Title: Low plasma levels of the soluble receptor for advanced glycation end products in HIV-infected patients with subclinical carotid atherosclerosis receiving combined antiretroviral therapy.
    10. The expression of eosinophil RAGE, soluble RAGE and RAGE ligands may be pivotal to the functions of eosinophils in various human diseases involving RAGE and S100 ligands.
      Title: Human eosinophils express RAGE, produce RAGE ligands, exhibit PKC-delta phosphorylation and enhanced viability in response to the RAGE ligand, S100B.
    Submit: New GeneRIF Correction See all (330)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study identifies five loci associated with lung function.

    Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15109 P09429 HMGB1    HPRD  PubMed  
    Q15109 P23297 S100A1    HPRD  PubMed  
    Q15109 P80511 S100A12    HPRD  PubMed  
    Q15109 P04271 S100B    HPRD  PubMed  
    Q15109 P25815 S100P    HPRD  PubMed  
    Q15109 P02766 TTR    HPRD  PubMed  
    BioGRID:106685 BioGRID:112194 S100P    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Advanced glycosylation endproduct receptor signaling, organism-specific biosystem (from REACTOME)
      Advanced glycosylation endproduct receptor signaling, organism-specific biosystemAdvanced Glycosylation End- product-specific Receptor (AGER) also known as Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin supe...
    • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
      Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
    • DAI mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
      DAI mediated induction of type I IFNs, organism-specific biosystemDNA-dependent activator of IFN-regulatory factors (DAI), also known as Z-DNA-binding protein-1 (ZBP-1), was reported to initiate innate immune responses in murine L929 cells upon stimulation by multi...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88-independent cascade initiated on plasma membrane, organism-specific biosystemThe MyD88-independent signaling route utilizes TRAM and TRIF adapters, that are essential for production of both type 1 interferons(IFNs) and pro-inflammatory cytokines. TRAM is thought to bridge bet...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystem (from REACTOME)
      NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystemMitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascade tr...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • RIP-mediated NFkB activation via DAI, organism-specific biosystem (from REACTOME)
      RIP-mediated NFkB activation via DAI, organism-specific biosystemOverexpression of human or murine DAI in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are implic...
    • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
      TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
    • TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystem (from REACTOME)
      TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystemIn human, together with ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitination. It is believed that auto polyubiquitination and oli...
    • TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated NF-kB activation, organism-specific biosystemThe TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in To...
    • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRIF mediated TLR3 signaling, organism-specific biosystem (from REACTOME)
      TRIF mediated TLR3 signaling, organism-specific biosystemTIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known to be an essential and exclusive adaptor used by TLR3; all the poly(I:C)-induced pathways leading to NFkB and IRF3 act...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
      Toll Receptor Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Viral dsRNA:TLR3:TRIF Complex Activates RIP1, organism-specific biosystem (from REACTOME)
      Viral dsRNA:TLR3:TRIF Complex Activates RIP1, organism-specific biosystemReceptor-interacting protein 1 (RIP1) mediates the activation of interferon-alpha/beta via intermediate activation of IKK/TBK1 or NFkB pathways.
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    S100 alpha binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    advanced glycation end-product receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    induction of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    lung development IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to wounding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    advanced glycosylation end product-specific receptor
    Names
    advanced glycosylation end product-specific receptor
    RAGE isoform sRAGE-delta
    RAGE isoform NtRAGE-delta
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029868.1 RefSeqGene

      Range
      5001..8355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136.4 → NP_001127.1  advanced glycosylation end product-specific receptor isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as RAGE) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AK298100, BM971899
      Consensus CDS
      CCDS4746.1
      UniProtKB/TrEMBL
      B4DNX3
      UniProtKB/Swiss-Prot
      Q15109
      UniProtKB/TrEMBL
      Q3L1S0
      Related
      ENSP00000364217, OTTHUMP00000029155, ENST00000375076, OTTHUMT00000076200
      Conserved Domains (2) summary
      cd00096
      Location:255 – 307
      Blast Score: 105
      Ig; Immunoglobulin domain
      cl11960
      Location:124 – 219
      Blast Score: 220
      Ig; Immunoglobulin domain

    2. NM_001206929.1 → NP_001193858.1  advanced glycosylation end product-specific receptor isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as RAGE_v5) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a longer isoform (2) containing an additional protein segment compared to isoform 1.
      Source sequence(s)
      AK298100, AY755621, BM971899
      UniProtKB/TrEMBL
      B4DNX3
      UniProtKB/TrEMBL
      Q3L1R8
      Conserved Domains (2) summary
      cd00096
      Location:271 – 323
      Blast Score: 104
      Ig; Immunoglobulin domain
      cl11960
      Location:124 – 235
      Blast Score: 192
      Ig; Immunoglobulin domain

    3. NM_001206932.1 → NP_001193861.1  advanced glycosylation end product-specific receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as RAGE_v4) uses alternate in-frame acceptor and donor splice sites at two internal coding exons compared to variant 1. This results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.
      Source sequence(s)
      AK298100, AY755624, BM971899
      UniProtKB/TrEMBL
      B4DNX3
      UniProtKB/TrEMBL
      Q3L1R5
      Conserved Domains (2) summary
      cd00096
      Location:241 – 293
      Blast Score: 105
      Ig; Immunoglobulin domain
      cl11960
      Location:110 – 205
      Blast Score: 221
      Ig; Immunoglobulin domain

    4. NM_001206934.1 → NP_001193863.1  advanced glycosylation end product-specific receptor isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as RAGE_v6) lacks the penultimate coding exon, and uses alternate donor splice sites at two internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (4) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK298100, AY755622, BM971899
      Consensus CDS
      CCDS56417.1
      UniProtKB/TrEMBL
      B4DNX3
      Related
      ENSP00000387887, ENST00000438221
      Conserved Domains (2) summary
      cd00096
      Location:271 – 323
      Blast Score: 104
      Ig; Immunoglobulin domain
      cl11960
      Location:124 – 235
      Blast Score: 195
      Ig; Immunoglobulin domain

    5. NM_001206936.1 → NP_001193865.1  advanced glycosylation end product-specific receptor isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as RAGE_v9) lacks the penultimate coding exon, and uses alternate acceptor and donor splice sites at two internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (5) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK298100, AY755623, BM971899
      UniProtKB/TrEMBL
      B4DNX3
      UniProtKB/TrEMBL
      Q3L1R6
      Conserved Domains (1) summary
      cl11960
      Location:124 – 219
      Blast Score: 225
      Ig; Immunoglobulin domain

    6. NM_001206940.1 → NP_001193869.1  advanced glycosylation end product-specific receptor isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as RAGE_v1) lacks the penultimate coding exon, and uses an alternate donor splice site at another coding exon compared to variant 1. This results in a frame-shift and a shorter isoform (6, also known as esRAGE and soluble RAGE) with a distinct C-terminus compared to isoform 1. This isoform lacks the transmembrane and intracellular domains, is secreted (PMID:18089847), and thought to function as a decoy receptor that inhibits RAGE signaling, and thus prevent the pathological progression of some pathologic conditions, such as Alzheimer's disease (PMID:18431028). Variants 6 and 9 encode the same isoform.
      Source sequence(s)
      AK298100, AY755620, BM971899
      Consensus CDS
      CCDS56418.1
      UniProtKB/TrEMBL
      B4DNX3
      UniProtKB/Swiss-Prot
      Q15109
      Related
      ENSP00000364195, OTTHUMP00000174885, ENST00000375055, OTTHUMT00000268937
      Conserved Domains (2) summary
      cd00096
      Location:255 – 307
      Blast Score: 105
      Ig; Immunoglobulin domain
      cl11960
      Location:124 – 219
      Blast Score: 224
      Ig; Immunoglobulin domain

    7. NM_001206954.1 → NP_001193883.1  advanced glycosylation end product-specific receptor isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as RAGE_v8) lacks two internal coding exons, and uses an alternate donor splice site at another coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (8) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK298100, BM971899, EU117141
      UniProtKB/TrEMBL
      A7Y2U9
      UniProtKB/TrEMBL
      B4DNX3
      Conserved Domains (1) summary
      cl11960
      Location:124 – 219
      Blast Score: 227
      Ig; Immunoglobulin domain

    8. NM_001206966.1 → NP_001193895.1  advanced glycosylation end product-specific receptor isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9, also known as RAGE_v10) lacks the penultimate coding exon, and uses alternate splice sites at other exons at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (6, also known as esRAGE and soluble RAGE) with a distinct C-terminus compared to isoform 1. Variants 6 and 9 encode the same isoform.
      Source sequence(s)
      AK298100, AY755628, BM971899
      Consensus CDS
      CCDS56418.1
      UniProtKB/TrEMBL
      B4DNX3
      UniProtKB/Swiss-Prot
      Q15109
      Conserved Domains (2) summary
      cd00096
      Location:255 – 307
      Blast Score: 105
      Ig; Immunoglobulin domain
      cl11960
      Location:124 – 219
      Blast Score: 224
      Ig; Immunoglobulin domain

    9. NM_172197.2 → NP_751947.1  advanced glycosylation end product-specific receptor isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as RAGE_v16) uses alternate splice sites at several internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (7, also known as hRAGEsec) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AJ133822, AK298100, BM971899
      Consensus CDS
      CCDS4747.1
      UniProtKB/TrEMBL
      B4DNX3
      UniProtKB/Swiss-Prot
      Q15109
      Related
      ENSP00000364208, OTTHUMP00000029156, ENST00000375067, OTTHUMT00000076201
      Conserved Domains (1) summary
      cl11960
      Location:110 – 205
      Blast Score: 228
      Ig; Immunoglobulin domain

    RNA

    1. NR_038190.1 RNA Sequence

      Description
      Transcript Variant: This variant (10, also known as RAGE_v2) is alternatively spliced at the 5' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon (with a strong Kozak signal), renders this transcript a candidate for nonsense-mediated mRNA decay (NMD). Transfection studies also could not detect expression of any protein from this variant (PMID:18089847).
      Source sequence(s)
      AK298100, BM971899, DQ104254

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      32148745..32152099, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.1 Reference GRCh37.p5 ALT_REF_LOCI_1

      Range
      3463486..3466840, complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      3619426..3622780, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      3491569..3494923, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      3528572..3531926, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      3409765..3413119, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      3496473..3499827, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      31902943..31906297, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF001095.1 None
    genomic AF065211.1 AAD15888.1
    genomic AF065212.1 AAD15889.1
    genomic AF208289.1 AAG35728.1
    genomic AJ238896.1 CAB43094.1
    genomic AL662830.14 (4608..7885) None
    genomic AL662884.11 (93794..97071) None
    genomic AL845464.5 CAI41809.1
      CAI41810.1
      CAI41811.2
      CAM25716.1
    genomic AL845464.5 CAI41809.1
      CAI41810.1
      CAI41811.2
      CAM25716.1
    genomic BX284686.9 CAM26223.1
      CAM26224.1
      CAM26225.1
    genomic BX927239.5 CAQ06595.1
      CAQ06596.1
      CAQ06597.1
    genomic CH471081.1 EAX03610.1
      EAX03611.1
    genomic CR812478.6 (48040..51317) None
    genomic CR933878.7 (50867..54144) None
    genomic CS300822.1 CAK32486.1
    genomic D28769.1 BAA05958.1
    genomic U89336.1 AAB47491.1
    mRNA AB036432.1 BAA89369.1
    mRNA AB061668.1 BAC65465.1
    mRNA AB061669.1 BAC65466.1
    mRNA AF536236.1 AAQ10685.1
    mRNA AF536237.1 AAQ10686.1
    mRNA AF537303.1 AAQ10782.1
    mRNA AJ133822.1 CAB43108.1
    mRNA AK298100.1 BAG60385.1
    mRNA AK313178.1 BAG35995.1
    mRNA AY755619.1 AAX07272.1
    mRNA AY755620.1 AAX07273.1
    mRNA AY755621.1 AAX07274.1
    mRNA AY755622.1 AAX07275.1
    mRNA AY755623.1 AAX07276.1
    mRNA AY755624.1 AAX07277.1
    mRNA AY755625.1 AAX07278.1
    mRNA AY755626.1 AAX07279.1
    mRNA AY755627.1 AAX07280.1
    mRNA AY755628.1 AAX07281.1
    mRNA BC020669.1 AAH20669.1
    mRNA BM971899.1 None
    mRNA DQ104251.1 AAZ32412.1
    mRNA DQ104252.1 AAZ32413.1
    mRNA DQ104253.1 AAZ32414.1
    mRNA DQ104254.1 AAZ32415.1
    mRNA EU117141.1 ABV03807.1
    mRNA EU428811.1 ACE78167.1
    mRNA EU428812.1 ACE78168.1
    mRNA EU428813.1 ACE78169.1
    mRNA EU428814.1 None
    mRNA EU428815.1 ACE78170.1
    mRNA EU428816.1 None
    mRNA EU826616.1 ACF47652.1
    mRNA EU826617.1 ACF47653.1
    mRNA EU826618.1 ACF47654.1
    mRNA EU826619.1 ACF47655.1
    mRNA EU826620.1 ACF47656.1
    mRNA FJ545655.1 ACL80027.1
    mRNA GU139370.1 None
    mRNA GU139371.1 ADQ42256.1
    mRNA GU139372.1 None
    mRNA GU139373.1 ADQ42257.1
    mRNA GU139374.1 ADQ42258.1
    mRNA GU139375.1 ADQ42259.1
    mRNA GU139376.1 ADQ42260.1
    mRNA GU139377.1 ADQ42261.1
    mRNA GU139378.1 ADQ42262.1
    mRNA GU139379.1 None
    mRNA GU139381.1 None
    mRNA GU139382.1 None
    mRNA HQ148133.1 ADV92535.1
    mRNA HQ148134.1 ADV92536.1
    mRNA HQ148135.1 ADV92537.1
    mRNA M91211.1 AAA03574.1
    other-genetic DQ893575.2 ABM84501.1
    other-genetic DQ896821.2 ABM87820.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95795 GenPept UniProtKB/TrEMBL:O95795
    Q101R2 GenPept UniProtKB/TrEMBL:Q101R2
    Q101R3 GenPept UniProtKB/TrEMBL:Q101R3
    Q101R5 GenPept UniProtKB/TrEMBL:Q101R5
    Q15109.1 GenPept UniProtKB/Swiss-Prot:Q15109
    Q3L1R2 GenPept UniProtKB/TrEMBL:Q3L1R2
    Q3L1R3 GenPept UniProtKB/TrEMBL:Q3L1R3
    Q3L1R4 GenPept UniProtKB/TrEMBL:Q3L1R4
    Q3L1R5 GenPept UniProtKB/TrEMBL:Q3L1R5
    Q3L1R6 GenPept UniProtKB/TrEMBL:Q3L1R6
    Q3L1R8 GenPept UniProtKB/TrEMBL:Q3L1R8
    Q3L1S0 GenPept UniProtKB/TrEMBL:Q3L1S0
    Q5JP26 GenPept UniProtKB/TrEMBL:Q5JP26
    Q5SSZ2 GenPept UniProtKB/TrEMBL:Q5SSZ2
    Q5SSZ3 GenPept UniProtKB/TrEMBL:Q5SSZ3
    Q71BB6 GenPept UniProtKB/TrEMBL:Q71BB6
    Q71BG7 GenPept UniProtKB/TrEMBL:Q71BG7
    Q71UQ2 GenPept UniProtKB/TrEMBL:Q71UQ2
    Q9UQR5 GenPept UniProtKB/TrEMBL:Q9UQR5
    Help top of page

    Additional Links

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